ID   COBW_PSEAE              Reviewed;         375 AA.
AC   Q9HZQ2;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Protein CobW;
GN   Name=cobW; OrderedLocusNames=PA2945;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- FUNCTION: Might be involved in cobalt reduction leading to cobalt(I)
CC       corrinoids. {ECO:0000250}.
CC   -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC   -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. CobW
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AE004091; AAG06333.1; -; Genomic_DNA.
DR   PIR; D83276; D83276.
DR   RefSeq; NP_251635.1; NC_002516.2.
DR   RefSeq; WP_010895644.1; NZ_QZGE01000009.1.
DR   AlphaFoldDB; Q9HZQ2; -.
DR   SMR; Q9HZQ2; -.
DR   STRING; 287.DR97_4995; -.
DR   PaxDb; Q9HZQ2; -.
DR   PRIDE; Q9HZQ2; -.
DR   EnsemblBacteria; AAG06333; AAG06333; PA2945.
DR   GeneID; 882832; -.
DR   KEGG; pae:PA2945; -.
DR   PATRIC; fig|208964.12.peg.3089; -.
DR   PseudoCAP; PA2945; -.
DR   HOGENOM; CLU_017452_1_0_6; -.
DR   InParanoid; Q9HZQ2; -.
DR   OMA; IDVENWE; -.
DR   PhylomeDB; Q9HZQ2; -.
DR   BioCyc; PAER208964:G1FZ6-2996-MON; -.
DR   UniPathway; UPA00148; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1220.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR012824; Cbl_biosynth_CobW.
DR   InterPro; IPR011629; Cbl_biosynth_CobW-like_C.
DR   InterPro; IPR036627; CobW-likC_sf.
DR   InterPro; IPR003495; CobW/HypB/UreG_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF02492; cobW; 1.
DR   Pfam; PF07683; CobW_C; 1.
DR   SMART; SM00833; CobW_C; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR02475; CobW; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cobalamin biosynthesis; Nucleotide-binding;
KW   Porphyrin biosynthesis; Reference proteome.
FT   CHAIN           1..375
FT                   /note="Protein CobW"
FT                   /id="PRO_0000287790"
FT   DOMAIN          283..374
FT                   /note="CobW C-terminal"
FT   REGION          173..192
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         39..46
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   BINDING         104..108
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   BINDING         212..215
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   375 AA;  41207 MW;  198522662BD779A7 CRC64;
     MANPLRGPCV RATRPHARRA EQGLPMKTLA KLPVTIVTGF LGAGKTTLLR HMLDNAEGRR
     IAVIVNEFGE LGIDGEILKQ CSIGCSEEEA QGRVFELANG CLCCTVQEEF FPVMRELVAR
     RGDLDQILIE TSGLALPKPL VQAFQWPEIR NACTVDAVIT VVDSPAVAAG TFAAHPEQVD
     QQRRQDPNLD HESPLHELFE DQLASADLVI LNKADQLDAE ALARVRAEIA GELPAAVKIV
     EASRGELPLP VLLGLNAEAE LHIDGRPTHH DHEGHEDHDH DEFDSFHVDL PEVEEAALLE
     ALGELVERHD ILRIKGFAAI PGKPMRLLVQ GVGKRFDRHF DRKWLADEAR STRLVVIGQE
     LDQAAIANQL RTALA