ID   COCC_CONCL              Reviewed;          43 AA.
AC   A7LI91;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   25-MAY-2022, entry version 27.
DE   RecName: Full=Mu-conotoxin-like Cal 12.2c;
DE   AltName: Full=Conotoxin CalTx 12.2.1C;
DE   Flags: Precursor; Fragment;
OS   Californiconus californicus (California cone) (Conus californicus).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Californiconus.
OX   NCBI_TaxID=1736779;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=21147978; DOI=10.1242/jeb.046086;
RA   Gilly W.F., Richmond T.A., Duda T.F. Jr., Elliger C., Lebaric Z.,
RA   Schulz J., Bingham J.P., Sweedler J.V.;
RT   "A diverse family of novel peptide toxins from an unusual cone snail, Conus
RT   californicus.";
RL   J. Exp. Biol. 214:147-161(2011).
CC   -!- FUNCTION: Mu-conotoxins block voltage-gated sodium channels. This toxin
CC       reversibly blocks voltage-gated sodium channel in cephalopods, with no
CC       alteration in the voltage dependence of sodium conductance or on the
CC       kinetics of inactivation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is XII (C-C-C-C-CC-C-C).
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DR   EMBL; EU022529; ABS59786.1; -; mRNA.
DR   AlphaFoldDB; A7LI91; -.
DR   ConoServer; 818; Cal12.2c.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Bromination; Disulfide bond; Hydroxylation; Ion channel impairing toxin;
KW   Neurotoxin; Secreted; Toxin.
FT   PROPEP          <1..1
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000392283"
FT   PEPTIDE         2..43
FT                   /note="Mu-conotoxin-like Cal 12.2c"
FT                   /id="PRO_0000392284"
FT   MOD_RES         31
FT                   /note="6'-bromotryptophan"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         36
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         40
FT                   /note="6'-bromotryptophan"
FT                   /evidence="ECO:0000250"
FT   DISULFID        4..16
FT                   /evidence="ECO:0000305"
FT   DISULFID        11..24
FT                   /evidence="ECO:0000250"
FT   DISULFID        18..29
FT                   /evidence="ECO:0000250"
FT   DISULFID        23..35
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
SQ   SEQUENCE   43 AA;  4582 MW;  458BC5D3E75C3132 CRC64;
     RGVCSTPEGS CVHNGCICQN APCCHPSGCN WANVCPGYLW DKN