ID   COCE_CONCL              Reviewed;          43 AA.
AC   A9UH01;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 25.
DE   RecName: Full=Mu-conotoxin-like CalTx 12.2.1E;
DE   Flags: Precursor; Fragment;
OS   Californiconus californicus (California cone) (Conus californicus).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Californiconus.
OX   NCBI_TaxID=1736779;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Gilly W.F., Richmond T.A., Elliger C., Lebaric Z., Schulz J., Bingham J.P.,
RA   Sweedler J.V.;
RT   "Extreme diversity in a novel family of peptide toxins from Conus
RT   californicus.";
RL   Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mu-conotoxins block voltage-gated sodium channels. This toxin
CC       reversibly blocks voltage-gated sodium channel in cephalopods, with no
CC       alteration in the voltage dependence of sodium conductance or on the
CC       kinetics of inactivation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is XII (C-C-C-C-CC-C-C).
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DR   EMBL; EU284127; ABX79671.1; -; mRNA.
DR   AlphaFoldDB; A9UH01; -.
DR   ConoServer; 2785; CalTx 12.2.1E.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Bromination; Disulfide bond; Hydroxylation; Ion channel impairing toxin;
KW   Neurotoxin; Secreted; Toxin.
FT   PROPEP          <1..1
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000392287"
FT   PEPTIDE         2..43
FT                   /note="Mu-conotoxin-like CalTx 12.2.1E"
FT                   /id="PRO_0000392288"
FT   MOD_RES         31
FT                   /note="6'-bromotryptophan"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         36
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         40
FT                   /note="6'-bromotryptophan"
FT                   /evidence="ECO:0000250"
FT   DISULFID        4..16
FT                   /evidence="ECO:0000305"
FT   DISULFID        11..24
FT                   /evidence="ECO:0000250"
FT   DISULFID        18..29
FT                   /evidence="ECO:0000250"
FT   DISULFID        23..35
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
SQ   SEQUENCE   43 AA;  4598 MW;  4590C463E74EA132 CRC64;
     RGVCSTPEGS CVHNGCICQN APCCHESGCN WANVCPGFLW DKN