CODB_ECO57
ID CODB_ECO57 Reviewed; 419 AA.
AC Q8X691; Q7AH64;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Cytosine permease;
GN Name=codB; OrderedLocusNames=Z0432, ECs0389;
OS Escherichia coli O157:H7.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83334;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX PubMed=11206551; DOI=10.1038/35054089;
RA Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA Blattner F.R.;
RT "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL Nature 409:529-533(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA Shiba T., Hattori M., Shinagawa H.;
RT "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT genomic comparison with a laboratory strain K-12.";
RL DNA Res. 8:11-22(2001).
CC -!- FUNCTION: Required for cytosine transport into the cell.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the purine-cytosine permease (2.A.39) family.
CC {ECO:0000305}.
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DR EMBL; AE005174; AAG54685.1; -; Genomic_DNA.
DR EMBL; BA000007; BAB33812.1; -; Genomic_DNA.
DR PIR; A85528; A85528.
DR PIR; E90677; E90677.
DR RefSeq; NP_308416.1; NC_002695.1.
DR RefSeq; WP_000076226.1; NZ_SWKA01000005.1.
DR AlphaFoldDB; Q8X691; -.
DR SMR; Q8X691; -.
DR STRING; 155864.EDL933_0396; -.
DR EnsemblBacteria; AAG54685; AAG54685; Z0432.
DR EnsemblBacteria; BAB33812; BAB33812; ECs_0389.
DR GeneID; 914491; -.
DR KEGG; ece:Z0432; -.
DR KEGG; ecs:ECs_0389; -.
DR PATRIC; fig|386585.9.peg.484; -.
DR eggNOG; COG1457; Bacteria.
DR HOGENOM; CLU_035711_1_1_6; -.
DR OMA; NTIYNFA; -.
DR Proteomes; UP000000558; Chromosome.
DR Proteomes; UP000002519; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015209; F:cytosine transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0019858; P:cytosine metabolic process; IEA:UniProtKB-KW.
DR InterPro; IPR030191; CodB.
DR InterPro; IPR001248; Pur-cyt_permease.
DR PANTHER; PTHR30569; PTHR30569; 1.
DR Pfam; PF02133; Transp_cyt_pur; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Cytosine metabolism; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..419
FT /note="Cytosine permease"
FT /id="PRO_0000197933"
FT TOPO_DOM 1..19
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 20..39
FT /note="Helical; Name=1"
FT /evidence="ECO:0000305"
FT TOPO_DOM 40..51
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 52..71
FT /note="Helical; Name=2"
FT /evidence="ECO:0000305"
FT TOPO_DOM 72..100
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000305"
FT TOPO_DOM 121..127
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 128..147
FT /note="Helical; Name=4"
FT /evidence="ECO:0000305"
FT TOPO_DOM 148..152
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 153..172
FT /note="Helical; Name=5"
FT /evidence="ECO:0000305"
FT TOPO_DOM 173..192
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 193..212
FT /note="Helical; Name=6"
FT /evidence="ECO:0000305"
FT TOPO_DOM 213..221
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 222..242
FT /note="Helical; Name=7"
FT /evidence="ECO:0000305"
FT TOPO_DOM 243..257
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 258..277
FT /note="Helical; Name=8"
FT /evidence="ECO:0000305"
FT TOPO_DOM 278..300
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 301..320
FT /note="Helical; Name=9"
FT /evidence="ECO:0000305"
FT TOPO_DOM 321
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 322..341
FT /note="Helical; Name=10"
FT /evidence="ECO:0000305"
FT TOPO_DOM 342..358
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 359..378
FT /note="Helical; Name=11"
FT /evidence="ECO:0000305"
FT TOPO_DOM 379..380
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 381..400
FT /note="Helical; Name=12"
FT /evidence="ECO:0000305"
FT TOPO_DOM 401..419
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
SQ SEQUENCE 419 AA; 43664 MW; CC4D64BD88827D93 CRC64;
MSQDNNFSQG PVPQSARKGV LALTFVMLGL TFFSASMWTG GTLGTGLSYH DFFLAVLIGN
LLLGIYTSFL GYIGAKTGLT THLLARFSFG VKGSWLPSLL LGGTQVGWFG VGVAMFAIPV
GKATGLDINL LIAVSGLLMT VTVFFGISAL TVLSLIAVPA IACLGGYSVW LAVNGMGGLD
ALKAVVPAQP LDFNVALALV VGSFISAGTL TADFVRFGRN AKLAVLVAMV AFFLGNSLMF
IFGAAGAAAL GMADISDVMI AQGLLLPAIV VLGLNIWTTN DNALYASGLG FANITGMSSK
TLSVINGIIG TVCALWLYNN FVGWLTFLSA AIPPVGGVII ADYLMNRRRY EHFATTRMMS
VNWVAILAVA LGIAAGHWLP GIVPVNAVLG GALSYLILNP ILNRKTTAAM THVEANSVE
