CODB_ECOL6
ID CODB_ECOL6 Reviewed; 419 AA.
AC P0AA83; P25525;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Cytosine permease;
GN Name=codB; OrderedLocusNames=c0455;
OS Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=199310;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CFT073 / ATCC 700928 / UPEC;
RX PubMed=12471157; DOI=10.1073/pnas.252529799;
RA Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA Donnenberg M.S., Blattner F.R.;
RT "Extensive mosaic structure revealed by the complete genome sequence of
RT uropathogenic Escherichia coli.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC -!- FUNCTION: Required for cytosine transport into the cell. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the purine-cytosine permease (2.A.39) family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE014075; AAN78934.1; -; Genomic_DNA.
DR RefSeq; WP_000076233.1; NC_004431.1.
DR AlphaFoldDB; P0AA83; -.
DR SMR; P0AA83; -.
DR STRING; 199310.c0455; -.
DR EnsemblBacteria; AAN78934; AAN78934; c0455.
DR KEGG; ecc:c0455; -.
DR eggNOG; COG1457; Bacteria.
DR HOGENOM; CLU_035711_1_1_6; -.
DR OMA; NTIYNFA; -.
DR BioCyc; ECOL199310:C0455-MON; -.
DR Proteomes; UP000001410; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015209; F:cytosine transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0019858; P:cytosine metabolic process; IEA:UniProtKB-KW.
DR InterPro; IPR030191; CodB.
DR InterPro; IPR001248; Pur-cyt_permease.
DR PANTHER; PTHR30569; PTHR30569; 1.
DR Pfam; PF02133; Transp_cyt_pur; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Cytosine metabolism; Membrane;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..419
FT /note="Cytosine permease"
FT /id="PRO_0000197934"
FT TOPO_DOM 1..19
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 20..39
FT /note="Helical; Name=1"
FT /evidence="ECO:0000305"
FT TOPO_DOM 40..51
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 52..71
FT /note="Helical; Name=2"
FT /evidence="ECO:0000305"
FT TOPO_DOM 72..100
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000305"
FT TOPO_DOM 121..127
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 128..147
FT /note="Helical; Name=4"
FT /evidence="ECO:0000305"
FT TOPO_DOM 148..152
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 153..172
FT /note="Helical; Name=5"
FT /evidence="ECO:0000305"
FT TOPO_DOM 173..192
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 193..212
FT /note="Helical; Name=6"
FT /evidence="ECO:0000305"
FT TOPO_DOM 213..221
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 222..242
FT /note="Helical; Name=7"
FT /evidence="ECO:0000305"
FT TOPO_DOM 243..257
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 258..277
FT /note="Helical; Name=8"
FT /evidence="ECO:0000305"
FT TOPO_DOM 278..300
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 301..320
FT /note="Helical; Name=9"
FT /evidence="ECO:0000305"
FT TOPO_DOM 321
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 322..341
FT /note="Helical; Name=10"
FT /evidence="ECO:0000305"
FT TOPO_DOM 342..358
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 359..378
FT /note="Helical; Name=11"
FT /evidence="ECO:0000305"
FT TOPO_DOM 379..380
FT /note="Periplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 381..400
FT /note="Helical; Name=12"
FT /evidence="ECO:0000305"
FT TOPO_DOM 401..419
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
SQ SEQUENCE 419 AA; 43650 MW; CB1EDEBD84AA1D93 CRC64;
MSQDNNFSQG PVPQSARKGV LALTFVMLGL TFFSASMWTG GTLGTGLSYH DFFLAVLIGN
LLLGIYTSFL GYIGAKTGLT THLLARFSFG VKGSWLPSLL LGGTQVGWFG VGVAMFAIPV
GKATGLDINL LIAVSGLLMT VTVFFGISAL TVLSVIAVPA IACLGGYSVW LAVNGMGGLD
ALKAVVPAQP LDFNVALALV VGSFISAGTL TADFVRFGRN AKLAVLVAMV AFFLGNSLMF
IFGAAGAAAL GMADISDVMI AQGLLLPAIV VLGLNIWTTN DNALYASGLG FANITGMSSK
TLSVINGIIG TVCALWLYNN FVGWLTFLSA AIPPVGGVII ADYLMNRRRY EHFATTRMMS
VNWVAILAVA LGIAAGHWLP GIVPVNAVLG GALSYLILNP ILNRKTTAAM THVEANSVE
