CODB_ECOLI
ID CODB_ECOLI Reviewed; 419 AA.
AC P0AA82; P25525; Q2MC88;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Cytosine permease;
GN Name=codB; OrderedLocusNames=b0336, JW0327;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=CSH01;
RX PubMed=1640834; DOI=10.1111/j.1365-2958.1992.tb00854.x;
RA Danielsen S., Kilstrup M., Barilla K., Jochimsen B., Neuhard J.;
RT "Characterization of the Escherichia coli codBA operon encoding cytosine
RT permease and cytosine deaminase.";
RL Mol. Microbiol. 6:1335-1344(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RA Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M.,
RA Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D.,
RA Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.;
RT "Sequence of minutes 4-25 of Escherichia coli.";
RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- FUNCTION: Required for cytosine transport into the cell.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the purine-cytosine permease (2.A.39) family.
CC {ECO:0000305}.
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DR EMBL; X63656; CAA45195.1; -; Genomic_DNA.
DR EMBL; U73857; AAB18060.1; -; Genomic_DNA.
DR EMBL; U00096; AAC73439.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE76118.1; -; Genomic_DNA.
DR PIR; S22661; S22661.
DR RefSeq; NP_414870.1; NC_000913.3.
DR RefSeq; WP_000076233.1; NZ_SSZK01000097.1.
DR AlphaFoldDB; P0AA82; -.
DR SMR; P0AA82; -.
DR BioGRID; 4259812; 7.
DR STRING; 511145.b0336; -.
DR TCDB; 2.A.39.1.1; the nucleobase:cation symporter-1 (ncs1) family.
DR PaxDb; P0AA82; -.
DR PRIDE; P0AA82; -.
DR EnsemblBacteria; AAC73439; AAC73439; b0336.
DR EnsemblBacteria; BAE76118; BAE76118; BAE76118.
DR GeneID; 944994; -.
DR KEGG; ecj:JW0327; -.
DR KEGG; eco:b0336; -.
DR PATRIC; fig|1411691.4.peg.1941; -.
DR EchoBASE; EB1303; -.
DR eggNOG; COG1457; Bacteria.
DR HOGENOM; CLU_035711_1_1_6; -.
DR InParanoid; P0AA82; -.
DR OMA; NTIYNFA; -.
DR PhylomeDB; P0AA82; -.
DR BioCyc; EcoCyc:CODB-MON; -.
DR BioCyc; MetaCyc:CODB-MON; -.
DR PRO; PR:P0AA82; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IDA:EcoCyc.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0015209; F:cytosine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0019858; P:cytosine metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0015856; P:cytosine transport; IBA:GO_Central.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:GOC.
DR InterPro; IPR030191; CodB.
DR InterPro; IPR001248; Pur-cyt_permease.
DR PANTHER; PTHR30569; PTHR30569; 1.
DR Pfam; PF02133; Transp_cyt_pur; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Cytosine metabolism; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..419
FT /note="Cytosine permease"
FT /id="PRO_0000197932"
FT TOPO_DOM 1..19
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305|PubMed:15919996"
FT TRANSMEM 20..39
FT /note="Helical; Name=1"
FT /evidence="ECO:0000305"
FT TOPO_DOM 40..51
FT /note="Periplasmic"
FT /evidence="ECO:0000305|PubMed:15919996"
FT TRANSMEM 52..71
FT /note="Helical; Name=2"
FT /evidence="ECO:0000305"
FT TOPO_DOM 72..100
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305|PubMed:15919996"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000305"
FT TOPO_DOM 121..127
FT /note="Periplasmic"
FT /evidence="ECO:0000305|PubMed:15919996"
FT TRANSMEM 128..147
FT /note="Helical; Name=4"
FT /evidence="ECO:0000305"
FT TOPO_DOM 148..152
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305|PubMed:15919996"
FT TRANSMEM 153..172
FT /note="Helical; Name=5"
FT /evidence="ECO:0000305"
FT TOPO_DOM 173..192
FT /note="Periplasmic"
FT /evidence="ECO:0000305|PubMed:15919996"
FT TRANSMEM 193..212
FT /note="Helical; Name=6"
FT /evidence="ECO:0000305"
FT TOPO_DOM 213..221
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305|PubMed:15919996"
FT TRANSMEM 222..242
FT /note="Helical; Name=7"
FT /evidence="ECO:0000305"
FT TOPO_DOM 243..257
FT /note="Periplasmic"
FT /evidence="ECO:0000305|PubMed:15919996"
FT TRANSMEM 258..277
FT /note="Helical; Name=8"
FT /evidence="ECO:0000305"
FT TOPO_DOM 278..300
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305|PubMed:15919996"
FT TRANSMEM 301..320
FT /note="Helical; Name=9"
FT /evidence="ECO:0000305"
FT TOPO_DOM 321
FT /note="Periplasmic"
FT /evidence="ECO:0000305|PubMed:15919996"
FT TRANSMEM 322..341
FT /note="Helical; Name=10"
FT /evidence="ECO:0000305"
FT TOPO_DOM 342..358
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305|PubMed:15919996"
FT TRANSMEM 359..378
FT /note="Helical; Name=11"
FT /evidence="ECO:0000305"
FT TOPO_DOM 379..380
FT /note="Periplasmic"
FT /evidence="ECO:0000305|PubMed:15919996"
FT TRANSMEM 381..400
FT /note="Helical; Name=12"
FT /evidence="ECO:0000305"
FT TOPO_DOM 401..419
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305|PubMed:15919996"
SQ SEQUENCE 419 AA; 43650 MW; CB1EDEBD84AA1D93 CRC64;
MSQDNNFSQG PVPQSARKGV LALTFVMLGL TFFSASMWTG GTLGTGLSYH DFFLAVLIGN
LLLGIYTSFL GYIGAKTGLT THLLARFSFG VKGSWLPSLL LGGTQVGWFG VGVAMFAIPV
GKATGLDINL LIAVSGLLMT VTVFFGISAL TVLSVIAVPA IACLGGYSVW LAVNGMGGLD
ALKAVVPAQP LDFNVALALV VGSFISAGTL TADFVRFGRN AKLAVLVAMV AFFLGNSLMF
IFGAAGAAAL GMADISDVMI AQGLLLPAIV VLGLNIWTTN DNALYASGLG FANITGMSSK
TLSVINGIIG TVCALWLYNN FVGWLTFLSA AIPPVGGVII ADYLMNRRRY EHFATTRMMS
VNWVAILAVA LGIAAGHWLP GIVPVNAVLG GALSYLILNP ILNRKTTAAM THVEANSVE
