ID   CODY_BACC1              Reviewed;         259 AA.
AC   Q732P2;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=GTP-sensing transcriptional pleiotropic repressor CodY {ECO:0000255|HAMAP-Rule:MF_00621};
GN   Name=codY {ECO:0000255|HAMAP-Rule:MF_00621}; OrderedLocusNames=BCE_3869;
OS   Bacillus cereus (strain ATCC 10987 / NRS 248).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=222523;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10987 / NRS 248;
RX   PubMed=14960714; DOI=10.1093/nar/gkh258;
RA   Rasko D.A., Ravel J., Oekstad O.A., Helgason E., Cer R.Z., Jiang L.,
RA   Shores K.A., Fouts D.E., Tourasse N.J., Angiuoli S.V., Kolonay J.F.,
RA   Nelson W.C., Kolstoe A.-B., Fraser C.M., Read T.D.;
RT   "The genome sequence of Bacillus cereus ATCC 10987 reveals metabolic
RT   adaptations and a large plasmid related to Bacillus anthracis pXO1.";
RL   Nucleic Acids Res. 32:977-988(2004).
CC   -!- FUNCTION: DNA-binding protein that represses the expression of many
CC       genes that are induced as cells make the transition from rapid
CC       exponential growth to stationary phase. It is a GTP-binding protein
CC       that senses the intracellular GTP concentration as an indicator of
CC       nutritional limitations. At low GTP concentration it no longer binds
CC       GTP and stop to act as a transcriptional repressor. {ECO:0000255|HAMAP-
CC       Rule:MF_00621}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00621}.
CC   -!- SIMILARITY: Belongs to the CodY family. {ECO:0000255|HAMAP-
CC       Rule:MF_00621}.
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DR   EMBL; AE017194; AAS42774.1; -; Genomic_DNA.
DR   RefSeq; WP_000421289.1; NC_003909.8.
DR   EnsemblBacteria; AAS42774; AAS42774; BCE_3869.
DR   KEGG; bca:BCE_3869; -.
DR   HOGENOM; CLU_089581_0_0_9; -.
DR   OMA; MPFVNVD; -.
DR   Proteomes; UP000002527; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00621; HTH_type_CodY; 1.
DR   InterPro; IPR014154; CodY.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR010312; GTP_sensing_CodY_N.
DR   InterPro; IPR013198; GTP_sensing_HTH_CodY_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR40062; PTHR40062; 1.
DR   Pfam; PF06018; CodY; 1.
DR   Pfam; PF08222; HTH_CodY; 1.
DR   PIRSF; PIRSF011572; GTP_sensing_CodY; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR02787; codY_Gpos; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; GTP-binding; Nucleotide-binding; Phosphoprotein;
KW   Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..259
FT                   /note="GTP-sensing transcriptional pleiotropic repressor
FT                   CodY"
FT                   /id="PRO_0000213214"
FT   DNA_BIND        202..221
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00621"
FT   MOD_RES         215
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00621"
SQ   SEQUENCE   259 AA;  28757 MW;  91C04A2CE3F0EFD2 CRC64;
     MELLAKTRKL NALLQSAAGK PVNFREMSDT MCEVIEANVF VVSRRGKLLG YAIHQQIENE
     RMKQMLAERQ FPEEYTQSLF NITETSSNLD VNSAYTAFPV ENKELFGQGL TTIVPIVGGG
     ERLGTLVLAR LGQEFLDDDL ILAEYSSTVV GMEILREKAE EIEEEARSKA VVQMAISSLS
     YSELEAIEHI FEELNGTEGL LVASKIADRV GITRSVIVNA LRKLESAGVI ESRSLGMKGT
     YIKVLNDKFL HELAXLKTN