CODY_BACC3
ID CODY_BACC3 Reviewed; 259 AA.
AC C1EP52;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 26-MAY-2009, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=GTP-sensing transcriptional pleiotropic repressor CodY {ECO:0000255|HAMAP-Rule:MF_00621};
GN Name=codY {ECO:0000255|HAMAP-Rule:MF_00621}; OrderedLocusNames=BCA_3927;
OS Bacillus cereus (strain 03BB102).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=572264;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=03BB102;
RA Dodson R.J., Jackson P., Munk A.C., Brettin T., Bruce D., Detter C.,
RA Tapia R., Han C., Sutton G., Sims D.;
RT "Genome sequence of Bacillus cereus 03BB102.";
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA-binding protein that represses the expression of many
CC genes that are induced as cells make the transition from rapid
CC exponential growth to stationary phase. It is a GTP-binding protein
CC that senses the intracellular GTP concentration as an indicator of
CC nutritional limitations. At low GTP concentration it no longer binds
CC GTP and stop to act as a transcriptional repressor. {ECO:0000255|HAMAP-
CC Rule:MF_00621}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00621}.
CC -!- SIMILARITY: Belongs to the CodY family. {ECO:0000255|HAMAP-
CC Rule:MF_00621}.
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DR EMBL; CP001407; ACO25892.1; -; Genomic_DNA.
DR RefSeq; WP_000421288.1; NZ_CP009318.1.
DR AlphaFoldDB; C1EP52; -.
DR SMR; C1EP52; -.
DR EnsemblBacteria; ACO25892; ACO25892; BCA_3927.
DR GeneID; 59155675; -.
DR GeneID; 64199167; -.
DR KEGG; bcx:BCA_3927; -.
DR PATRIC; fig|572264.18.peg.3884; -.
DR OMA; MPFVNVD; -.
DR Proteomes; UP000002210; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR HAMAP; MF_00621; HTH_type_CodY; 1.
DR InterPro; IPR014154; CodY.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR010312; GTP_sensing_CodY_N.
DR InterPro; IPR013198; GTP_sensing_HTH_CodY_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR40062; PTHR40062; 1.
DR Pfam; PF06018; CodY; 1.
DR Pfam; PF08222; HTH_CodY; 1.
DR PIRSF; PIRSF011572; GTP_sensing_CodY; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR TIGRFAMs; TIGR02787; codY_Gpos; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA-binding; GTP-binding; Nucleotide-binding; Phosphoprotein;
KW Repressor; Transcription; Transcription regulation.
FT CHAIN 1..259
FT /note="GTP-sensing transcriptional pleiotropic repressor
FT CodY"
FT /id="PRO_1000147200"
FT DNA_BIND 202..221
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00621"
FT MOD_RES 215
FT /note="Phosphoserine"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00621"
SQ SEQUENCE 259 AA; 28774 MW; 91C04A2CFA20EFD2 CRC64;
MELLAKTRKL NALLQSAAGK PVNFREMSDT MCEVIEANVF VVSRRGKLLG YAIHQQIENE
RMKQMLAERQ FPEEYTQSLF NITETSSNLD VNSAYTAFPV ENKELFGQGL TTIVPIVGGG
ERLGTLVLAR LGQEFLDDDL ILAEYSSTVV GMEILREKAE EIEEEARSKA VVQMAISSLS
YSELEAIEHI FEELNGTEGL LVASKIADRV GITRSVIVNA LRKLESAGVI ESRSLGMKGT
YIKVLNDKFL HELAKLKTN