CODY_BACCR
ID CODY_BACCR Reviewed; 259 AA.
AC Q819X8;
DT 25-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 125.
DE RecName: Full=GTP-sensing transcriptional pleiotropic repressor CodY {ECO:0000255|HAMAP-Rule:MF_00621};
GN Name=codY {ECO:0000255|HAMAP-Rule:MF_00621}; OrderedLocusNames=BC_3826;
OS Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC
OS 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=226900;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373
RC / NCTC 2599 / NRRL B-3711;
RX PubMed=12721630; DOI=10.1038/nature01582;
RA Ivanova N., Sorokin A., Anderson I., Galleron N., Candelon B., Kapatral V.,
RA Bhattacharyya A., Reznik G., Mikhailova N., Lapidus A., Chu L., Mazur M.,
RA Goltsman E., Larsen N., D'Souza M., Walunas T., Grechkin Y., Pusch G.,
RA Haselkorn R., Fonstein M., Ehrlich S.D., Overbeek R., Kyrpides N.C.;
RT "Genome sequence of Bacillus cereus and comparative analysis with Bacillus
RT anthracis.";
RL Nature 423:87-91(2003).
CC -!- FUNCTION: DNA-binding protein that represses the expression of many
CC genes that are induced as cells make the transition from rapid
CC exponential growth to stationary phase. It is a GTP-binding protein
CC that senses the intracellular GTP concentration as an indicator of
CC nutritional limitations. At low GTP concentration it no longer binds
CC GTP and stop to act as a transcriptional repressor. {ECO:0000255|HAMAP-
CC Rule:MF_00621}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00621}.
CC -!- SIMILARITY: Belongs to the CodY family. {ECO:0000255|HAMAP-
CC Rule:MF_00621}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE016877; AAP10748.1; -; Genomic_DNA.
DR RefSeq; NP_833547.1; NC_004722.1.
DR RefSeq; WP_000421290.1; NZ_CP034551.1.
DR PDB; 5EY2; X-ray; 3.00 A; A/B/C/D=1-259.
DR PDBsum; 5EY2; -.
DR AlphaFoldDB; Q819X8; -.
DR SMR; Q819X8; -.
DR STRING; 226900.BC_3826; -.
DR MetOSite; Q819X8; -.
DR EnsemblBacteria; AAP10748; AAP10748; BC_3826.
DR GeneID; 51135477; -.
DR GeneID; 67508462; -.
DR KEGG; bce:BC3826; -.
DR PATRIC; fig|226900.8.peg.3945; -.
DR HOGENOM; CLU_089581_0_0_9; -.
DR OMA; MPFVNVD; -.
DR Proteomes; UP000001417; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR HAMAP; MF_00621; HTH_type_CodY; 1.
DR InterPro; IPR014154; CodY.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR010312; GTP_sensing_CodY_N.
DR InterPro; IPR013198; GTP_sensing_HTH_CodY_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR40062; PTHR40062; 1.
DR Pfam; PF06018; CodY; 1.
DR Pfam; PF08222; HTH_CodY; 1.
DR PIRSF; PIRSF011572; GTP_sensing_CodY; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR TIGRFAMs; TIGR02787; codY_Gpos; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; DNA-binding; GTP-binding; Nucleotide-binding;
KW Phosphoprotein; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..259
FT /note="GTP-sensing transcriptional pleiotropic repressor
FT CodY"
FT /id="PRO_0000213215"
FT DNA_BIND 202..221
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00621"
FT MOD_RES 215
FT /note="Phosphoserine"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00621"
FT HELIX 3..17
FT /evidence="ECO:0007829|PDB:5EY2"
FT HELIX 24..34
FT /evidence="ECO:0007829|PDB:5EY2"
FT STRAND 37..43
FT /evidence="ECO:0007829|PDB:5EY2"
FT STRAND 46..52
FT /evidence="ECO:0007829|PDB:5EY2"
FT HELIX 60..67
FT /evidence="ECO:0007829|PDB:5EY2"
FT HELIX 73..78
FT /evidence="ECO:0007829|PDB:5EY2"
FT HELIX 79..81
FT /evidence="ECO:0007829|PDB:5EY2"
FT STRAND 86..89
FT /evidence="ECO:0007829|PDB:5EY2"
FT STRAND 110..117
FT /evidence="ECO:0007829|PDB:5EY2"
FT STRAND 119..133
FT /evidence="ECO:0007829|PDB:5EY2"
FT HELIX 137..178
FT /evidence="ECO:0007829|PDB:5EY2"
FT HELIX 181..194
FT /evidence="ECO:0007829|PDB:5EY2"
FT STRAND 196..200
FT /evidence="ECO:0007829|PDB:5EY2"
FT TURN 203..205
FT /evidence="ECO:0007829|PDB:5EY2"
FT STRAND 206..210
FT /evidence="ECO:0007829|PDB:5EY2"
FT HELIX 214..226
FT /evidence="ECO:0007829|PDB:5EY2"
FT STRAND 229..233
FT /evidence="ECO:0007829|PDB:5EY2"
FT STRAND 241..244
FT /evidence="ECO:0007829|PDB:5EY2"
FT HELIX 249..253
FT /evidence="ECO:0007829|PDB:5EY2"
SQ SEQUENCE 259 AA; 28793 MW; 5ACD5C6E90C31A73 CRC64;
MELLAKTRKL NALLQSAAGK PVNFREMSDT MCEVIEANVF VVSRRGKLLG YAIHQQIENE
RMKQMLAERQ FPEEYTQSLF NITETSSNLD VNSAYTAFPV ENRELFGQGL TTIVPIVGGG
ERLGTLVLAR LGQEFLDDDL ILAEYSSTVV GMEILREKAE EIEEEARSKA VVQMAISSLS
YSELEAIEHI FEELNGTEGL LVASKIADRV GITRSVIVNA LRKLESAGVI ESRSLGMKGT
YIKVLNDKFL QELAKLKTN
