ID   2ABB_XENTR              Reviewed;         443 AA.
AC   Q0D2F4; Q28HA4;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform;
DE   AltName: Full=PP2A subunit B isoform B55-beta;
DE   AltName: Full=PP2A subunit B isoform PR55-beta;
DE   AltName: Full=PP2A subunit B isoform R2-beta;
DE   AltName: Full=PP2A subunit B isoform beta;
GN   Name=ppp2r2b; Synonyms=ppp2r2c;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The B regulatory subunit might modulate substrate selectivity
CC       and catalytic activity, and also might direct the localization of the
CC       catalytic enzyme to a particular subcellular compartment. Negatively
CC       control the initiation of oocyte maturation (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: PP2A consists of a common heterodimeric core enzyme, composed
CC       of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant
CC       regulatory subunit (PR65 or subunit A), that associates with a variety
CC       of regulatory subunits. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton
CC       {ECO:0000250}. Membrane {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q0D2F4-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q0D2F4-2; Sequence=VSP_037986;
CC   -!- SIMILARITY: Belongs to the phosphatase 2A regulatory subunit B family.
CC       {ECO:0000305}.
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DR   EMBL; CR760964; CAJ82079.1; -; mRNA.
DR   EMBL; BC121844; AAI21845.1; -; mRNA.
DR   RefSeq; NP_001016458.1; NM_001016458.2.
DR   RefSeq; XP_012814476.1; XM_012959022.2. [Q0D2F4-1]
DR   AlphaFoldDB; Q0D2F4; -.
DR   SMR; Q0D2F4; -.
DR   STRING; 8364.ENSXETP00000045043; -.
DR   PaxDb; Q0D2F4; -.
DR   DNASU; 549212; -.
DR   Ensembl; ENSXETT00000070997; ENSXETP00000097004; ENSXETG00000020864.
DR   GeneID; 549212; -.
DR   KEGG; xtr:549212; -.
DR   CTD; 5521; -.
DR   Xenbase; XB-GENE-946380; ppp2r2b.
DR   eggNOG; KOG1354; Eukaryota.
DR   HOGENOM; CLU_021713_3_3_1; -.
DR   InParanoid; Q0D2F4; -.
DR   OrthoDB; 810409at2759; -.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000020864; Expressed in brain and 12 other tissues.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000159; C:protein phosphatase type 2A complex; IBA:GO_Central.
DR   GO; GO:0019888; F:protein phosphatase regulator activity; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR000009; PP2A_PR55.
DR   InterPro; IPR018067; PP2A_PR55_CS.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR11871; PTHR11871; 1.
DR   PIRSF; PIRSF037309; PP2A_PR55; 1.
DR   PRINTS; PR00600; PP2APR55.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS01024; PR55_1; 1.
DR   PROSITE; PS01025; PR55_2; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cytoplasm; Cytoskeleton; Membrane;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..443
FT                   /note="Serine/threonine-protein phosphatase 2A 55 kDa
FT                   regulatory subunit B beta isoform"
FT                   /id="PRO_0000383350"
FT   REPEAT          22..61
FT                   /note="WD 1"
FT   REPEAT          87..128
FT                   /note="WD 2"
FT   REPEAT          171..209
FT                   /note="WD 3"
FT   REPEAT          220..260
FT                   /note="WD 4"
FT   REPEAT          279..317
FT                   /note="WD 5"
FT   REPEAT          334..375
FT                   /note="WD 6"
FT   REPEAT          410..443
FT                   /note="WD 7"
FT   VAR_SEQ         1..23
FT                   /note="MEEDIDTRKINSSFLRDHSYATE -> MPCSIEDSVGSCNTRYSVMIPELQE
FT                   SIVFSEEARHCNGKYTRRQRKSS (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_037986"
SQ   SEQUENCE   443 AA;  51674 MW;  0FDBD5BFB7818BA9 CRC64;
     MEEDIDTRKI NSSFLRDHSY ATEADIISTV EFNSTGELLA TGDKGGRVVI FQREQENKNQ
     PHRRGEYNVY STFQSHEPEF DYLKSLEIEE KINKIRWLPQ QNAAYFLLST NDKTVKLWKV
     SERDKRPEGY NLKDEDGRIR DPCTITSLRV PVLRPMDLMV EATPRRVFSN AHTYHINSIS
     VNSDYETYMS ADDLRINLWN LEITNRSFNI VDIKPTNMEE LTEVITAAEF HPHNCNTFVY
     SSSKGTIRLC DMRSSALCDR HSKLFEEPED PSNRSFFSEI ISSISDVKFN HSGRYIMTRD
     YLTVKVWDLN MENRPIETYQ VHDYLRSKLC SLYENDCIFD KFECVWNGSD SVIMTGSYNN
     FFRMFDRNTK RDVTLEASRE NSKPRAILKP RKVCVGGKRR KDEISVDSLD FSKKILHTAW
     HPSENIIAVA ATNNLYIFQD KVN