ID   CODY_CLOB1              Reviewed;         258 AA.
AC   A7FPZ9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=GTP-sensing transcriptional pleiotropic repressor CodY {ECO:0000255|HAMAP-Rule:MF_00621};
GN   Name=codY {ECO:0000255|HAMAP-Rule:MF_00621}; OrderedLocusNames=CLB_2300;
OS   Clostridium botulinum (strain ATCC 19397 / Type A).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=441770;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19397 / Type A;
RX   PubMed=18060065; DOI=10.1371/journal.pone.0001271;
RA   Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C.,
RA   Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S.;
RT   "Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4
RT   and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within
RT   plasmids.";
RL   PLoS ONE 2:E1271-E1271(2007).
CC   -!- FUNCTION: DNA-binding protein that represses the expression of many
CC       genes that are induced as cells make the transition from rapid
CC       exponential growth to stationary phase. It is a GTP-binding protein
CC       that senses the intracellular GTP concentration as an indicator of
CC       nutritional limitations. At low GTP concentration it no longer binds
CC       GTP and stop to act as a transcriptional repressor. {ECO:0000255|HAMAP-
CC       Rule:MF_00621}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00621}.
CC   -!- SIMILARITY: Belongs to the CodY family. {ECO:0000255|HAMAP-
CC       Rule:MF_00621}.
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DR   EMBL; CP000726; ABS33369.1; -; Genomic_DNA.
DR   RefSeq; WP_003362579.1; NC_009697.1.
DR   AlphaFoldDB; A7FPZ9; -.
DR   SMR; A7FPZ9; -.
DR   GeneID; 45608579; -.
DR   GeneID; 5186691; -.
DR   KEGG; cba:CLB_2300; -.
DR   HOGENOM; CLU_089581_0_0_9; -.
DR   OMA; TETHANF; -.
DR   OrthoDB; 977877at2; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00621; HTH_type_CodY; 1.
DR   InterPro; IPR014154; CodY.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR010312; GTP_sensing_CodY_N.
DR   InterPro; IPR013198; GTP_sensing_HTH_CodY_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR40062; PTHR40062; 1.
DR   Pfam; PF06018; CodY; 1.
DR   Pfam; PF08222; HTH_CodY; 1.
DR   PIRSF; PIRSF011572; GTP_sensing_CodY; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR02787; codY_Gpos; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; GTP-binding; Nucleotide-binding; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..258
FT                   /note="GTP-sensing transcriptional pleiotropic repressor
FT                   CodY"
FT                   /id="PRO_1000051532"
FT   DNA_BIND        203..222
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00621"
SQ   SEQUENCE   258 AA;  29042 MW;  DB014602A8D7E48B CRC64;
     MSSLLDKTRM LNRILQKSGT EPVDFEDICD LLSDVLACNV YIISRKGKIL GSKFYSGFEC
     DEVREVVLKE NRFPDFYNNK LLNVNETLSN SPNHDKCVFD NLKDCSINNK LSTIVPINGN
     RERLGTLLLA RFDKEFTDED LVLAEYSATI IGLEILRSKQ DQIEEEARKK AVVQLAIGTL
     SYSELEAVEH IFNELDGTEG LLVASKIADK VGITRSVIVN ALRKFESAGV IESRSLGMKG
     THIRILNDKL LEELKKIK