CODY_STAA8
ID CODY_STAA8 Reviewed; 257 AA.
AC Q2FZ27;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 25-MAY-2022, entry version 106.
DE RecName: Full=GTP-sensing transcriptional pleiotropic repressor CodY {ECO:0000255|HAMAP-Rule:MF_00621};
GN Name=codY {ECO:0000255|HAMAP-Rule:MF_00621};
GN OrderedLocusNames=SAOUHSC_01228;
OS Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=93061;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC 8325 / PS 47;
RA Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT "The Staphylococcus aureus NCTC 8325 genome.";
RL (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL D.C. (2006).
CC -!- FUNCTION: DNA-binding protein that represses the expression of many
CC genes that are induced as cells make the transition from rapid
CC exponential growth to stationary phase. It is a GTP-binding protein
CC that senses the intracellular GTP concentration as an indicator of
CC nutritional limitations. At low GTP concentration it no longer binds
CC GTP and stop to act as a transcriptional repressor. {ECO:0000255|HAMAP-
CC Rule:MF_00621}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00621}.
CC -!- SIMILARITY: Belongs to the CodY family. {ECO:0000255|HAMAP-
CC Rule:MF_00621}.
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DR EMBL; CP000253; ABD30331.1; -; Genomic_DNA.
DR RefSeq; WP_000055337.1; NZ_LS483365.1.
DR RefSeq; YP_499763.1; NC_007795.1.
DR PDB; 5EY0; X-ray; 1.60 A; A/B=1-257.
DR PDB; 5EY1; X-ray; 2.00 A; A/B=1-257.
DR PDBsum; 5EY0; -.
DR PDBsum; 5EY1; -.
DR AlphaFoldDB; Q2FZ27; -.
DR SMR; Q2FZ27; -.
DR STRING; 1280.SAXN108_1257; -.
DR EnsemblBacteria; ABD30331; ABD30331; SAOUHSC_01228.
DR GeneID; 3920255; -.
DR KEGG; sao:SAOUHSC_01228; -.
DR PATRIC; fig|93061.5.peg.1125; -.
DR eggNOG; COG4465; Bacteria.
DR HOGENOM; CLU_089581_0_0_9; -.
DR OMA; MPFVNVD; -.
DR PRO; PR:Q2FZ27; -.
DR Proteomes; UP000008816; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR HAMAP; MF_00621; HTH_type_CodY; 1.
DR InterPro; IPR014154; CodY.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR010312; GTP_sensing_CodY_N.
DR InterPro; IPR013198; GTP_sensing_HTH_CodY_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR40062; PTHR40062; 1.
DR Pfam; PF06018; CodY; 1.
DR Pfam; PF08222; HTH_CodY; 1.
DR PIRSF; PIRSF011572; GTP_sensing_CodY; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR TIGRFAMs; TIGR02787; codY_Gpos; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; DNA-binding; GTP-binding; Nucleotide-binding;
KW Reference proteome; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..257
FT /note="GTP-sensing transcriptional pleiotropic repressor
FT CodY"
FT /id="PRO_1000051543"
FT DNA_BIND 202..221
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00621"
FT HELIX 3..16
FT /evidence="ECO:0007829|PDB:5EY0"
FT STRAND 18..21
FT /evidence="ECO:0007829|PDB:5EY0"
FT HELIX 24..35
FT /evidence="ECO:0007829|PDB:5EY0"
FT STRAND 38..43
FT /evidence="ECO:0007829|PDB:5EY0"
FT STRAND 47..52
FT /evidence="ECO:0007829|PDB:5EY0"
FT HELIX 55..58
FT /evidence="ECO:0007829|PDB:5EY0"
FT HELIX 60..68
FT /evidence="ECO:0007829|PDB:5EY0"
FT HELIX 73..80
FT /evidence="ECO:0007829|PDB:5EY0"
FT STRAND 86..89
FT /evidence="ECO:0007829|PDB:5EY0"
FT HELIX 100..106
FT /evidence="ECO:0007829|PDB:5EY0"
FT STRAND 110..118
FT /evidence="ECO:0007829|PDB:5EY0"
FT STRAND 121..132
FT /evidence="ECO:0007829|PDB:5EY0"
FT HELIX 137..178
FT /evidence="ECO:0007829|PDB:5EY0"
FT HELIX 181..192
FT /evidence="ECO:0007829|PDB:5EY0"
FT TURN 193..195
FT /evidence="ECO:0007829|PDB:5EY0"
FT STRAND 196..201
FT /evidence="ECO:0007829|PDB:5EY0"
FT HELIX 203..210
FT /evidence="ECO:0007829|PDB:5EY0"
FT HELIX 214..227
FT /evidence="ECO:0007829|PDB:5EY0"
FT STRAND 229..233
FT /evidence="ECO:0007829|PDB:5EY0"
FT STRAND 240..245
FT /evidence="ECO:0007829|PDB:5EY0"
FT HELIX 249..254
FT /evidence="ECO:0007829|PDB:5EY0"
SQ SEQUENCE 257 AA; 28755 MW; B62509C4F2B8DE53 CRC64;
MSLLSKTREL NTLLQKHKGI AVDFKDVAQT ISSVTVTNVF IVSRRGKILG SSLNELLKSQ
RIIQMLEERH IPSEYTERLM EVKQTESNID IDNVLTVFPP ENRELFIDSR TTIFPILGGG
ERLGTLVLGR VHDDFNENDL VLGEYAATVI GMEILREKHS EVEKEARDKA AITMAINSLS
YSEKEAIEHI FEELGGTEGL LIASKVADRV GITRSVIVNA LRKLESAGVI ESRSLGMKGT
FIKVKKEKFL DELEKSK
