位置:首页 > 蛋白库 > CODY_STAES
CODY_STAES
ID   CODY_STAES              Reviewed;         257 AA.
AC   Q8CPG9;
DT   25-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 115.
DE   RecName: Full=GTP-sensing transcriptional pleiotropic repressor CodY {ECO:0000255|HAMAP-Rule:MF_00621};
GN   Name=codY {ECO:0000255|HAMAP-Rule:MF_00621}; OrderedLocusNames=SE_0931;
OS   Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228 / FDA PCI 1200;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA   Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA   Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- FUNCTION: DNA-binding protein that represses the expression of many
CC       genes that are induced as cells make the transition from rapid
CC       exponential growth to stationary phase. It is a GTP-binding protein
CC       that senses the intracellular GTP concentration as an indicator of
CC       nutritional limitations. At low GTP concentration it no longer binds
CC       GTP and stop to act as a transcriptional repressor. {ECO:0000255|HAMAP-
CC       Rule:MF_00621}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00621}.
CC   -!- SIMILARITY: Belongs to the CodY family. {ECO:0000255|HAMAP-
CC       Rule:MF_00621}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE015929; AAO04528.1; -; Genomic_DNA.
DR   RefSeq; NP_764486.1; NC_004461.1.
DR   RefSeq; WP_002446289.1; NZ_WBME01000001.1.
DR   AlphaFoldDB; Q8CPG9; -.
DR   SMR; Q8CPG9; -.
DR   STRING; 176280.SE_0931; -.
DR   EnsemblBacteria; AAO04528; AAO04528; SE_0931.
DR   KEGG; sep:SE_0931; -.
DR   PATRIC; fig|176280.10.peg.906; -.
DR   eggNOG; COG4465; Bacteria.
DR   HOGENOM; CLU_089581_0_0_9; -.
DR   OMA; MPFVNVD; -.
DR   Proteomes; UP000001411; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00621; HTH_type_CodY; 1.
DR   InterPro; IPR014154; CodY.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR010312; GTP_sensing_CodY_N.
DR   InterPro; IPR013198; GTP_sensing_HTH_CodY_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR40062; PTHR40062; 1.
DR   Pfam; PF06018; CodY; 1.
DR   Pfam; PF08222; HTH_CodY; 1.
DR   PIRSF; PIRSF011572; GTP_sensing_CodY; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR02787; codY_Gpos; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; GTP-binding; Nucleotide-binding; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..257
FT                   /note="GTP-sensing transcriptional pleiotropic repressor
FT                   CodY"
FT                   /id="PRO_0000213237"
FT   DNA_BIND        202..221
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00621"
SQ   SEQUENCE   257 AA;  28860 MW;  1190648D8D2FC566 CRC64;
     MSLLSKTREL NTLLQKHKGI AVDFKDVAQT ISNVTVTNVF IVSRRGKILG SCLNELLKSE
     RIKDMLEDRH IPREYTEELM NVKQTESNID IDNELTVFPP ENREVFLNSR TTIFPILGGG
     ERLGTLVLGR VQDDFNENDL VLGEYAATVI GMEILREKHN EVEKEARDKA AITMAINSLS
     YSEKEAIEHI FEELGGTEGL LIASKVADRV GITRSVIVNA LRKLESAGVI ESRSLGMKGT
     FIKVKKDKFL DELEKNK
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024