ID   CODY_STRA1              Reviewed;         261 AA.
AC   Q3JZL4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=GTP-sensing transcriptional pleiotropic repressor CodY {ECO:0000255|HAMAP-Rule:MF_00621};
GN   Name=codY {ECO:0000255|HAMAP-Rule:MF_00621}; OrderedLocusNames=SAK_1687;
OS   Streptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC
OS   SS700).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=205921;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27591 / A909 / CDC SS700;
RX   PubMed=16172379; DOI=10.1073/pnas.0506758102;
RA   Tettelin H., Masignani V., Cieslewicz M.J., Donati C., Medini D.,
RA   Ward N.L., Angiuoli S.V., Crabtree J., Jones A.L., Durkin A.S., DeBoy R.T.,
RA   Davidsen T.M., Mora M., Scarselli M., Margarit y Ros I., Peterson J.D.,
RA   Hauser C.R., Sundaram J.P., Nelson W.C., Madupu R., Brinkac L.M.,
RA   Dodson R.J., Rosovitz M.J., Sullivan S.A., Daugherty S.C., Haft D.H.,
RA   Selengut J., Gwinn M.L., Zhou L., Zafar N., Khouri H., Radune D.,
RA   Dimitrov G., Watkins K., O'Connor K.J., Smith S., Utterback T.R., White O.,
RA   Rubens C.E., Grandi G., Madoff L.C., Kasper D.L., Telford J.L.,
RA   Wessels M.R., Rappuoli R., Fraser C.M.;
RT   "Genome analysis of multiple pathogenic isolates of Streptococcus
RT   agalactiae: implications for the microbial 'pan-genome'.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:13950-13955(2005).
CC   -!- FUNCTION: DNA-binding protein that represses the expression of many
CC       genes that are induced as cells make the transition from rapid
CC       exponential growth to stationary phase. It is a GTP-binding protein
CC       that senses the intracellular GTP concentration as an indicator of
CC       nutritional limitations. At low GTP concentration it no longer binds
CC       GTP and stop to act as a transcriptional repressor. {ECO:0000255|HAMAP-
CC       Rule:MF_00621}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00621}.
CC   -!- SIMILARITY: Belongs to the CodY family. {ECO:0000255|HAMAP-
CC       Rule:MF_00621}.
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DR   EMBL; CP000114; ABA44633.1; -; Genomic_DNA.
DR   RefSeq; WP_001133184.1; NC_007432.1.
DR   AlphaFoldDB; Q3JZL4; -.
DR   SMR; Q3JZL4; -.
DR   KEGG; sak:SAK_1687; -.
DR   HOGENOM; CLU_089581_0_0_9; -.
DR   OMA; MPFVNVD; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   CDD; cd00090; HTH_ARSR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00621; HTH_type_CodY; 1.
DR   InterPro; IPR011991; ArsR-like_HTH.
DR   InterPro; IPR014154; CodY.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR010312; GTP_sensing_CodY_N.
DR   InterPro; IPR013198; GTP_sensing_HTH_CodY_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR40062; PTHR40062; 1.
DR   Pfam; PF06018; CodY; 1.
DR   Pfam; PF08222; HTH_CodY; 1.
DR   PIRSF; PIRSF011572; GTP_sensing_CodY; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR02787; codY_Gpos; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; GTP-binding; Nucleotide-binding; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..261
FT                   /note="GTP-sensing transcriptional pleiotropic repressor
FT                   CodY"
FT                   /id="PRO_1000051547"
FT   DNA_BIND        206..225
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00621"
SQ   SEQUENCE   261 AA;  28971 MW;  3AE182D92EAED2A0 CRC64;
     MPNLLEKTRK ITSILQRSVD SLDAELPYNT MAAQLADIID CNACIINGGG NLLGYAMKYK
     TNTNRVEEFF ETKQFPDYYV KSASRVYDTE ANLSVDNDLS IFPVETKENF QDGITTIAPI
     YGGGMRLGTF IIWRNDKEFS DDDLILVEIA STVVGIQLLN LQTENLEENI RKQTAVTMAI
     NTLSYSEMKA VAAILGELDG LEGRLTASVI ADRIGITRSV IVNALRKLES AGIIESRSLG
     MKGTYLKVIN EGIFDKLKEY N