CODY_STRA3
ID CODY_STRA3 Reviewed; 261 AA.
AC P63846; P59387;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 25-MAY-2022, entry version 111.
DE RecName: Full=GTP-sensing transcriptional pleiotropic repressor CodY {ECO:0000255|HAMAP-Rule:MF_00621};
GN Name=codY {ECO:0000255|HAMAP-Rule:MF_00621}; OrderedLocusNames=gbs1719;
OS Streptococcus agalactiae serotype III (strain NEM316).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=211110;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEM316;
RX PubMed=12354221; DOI=10.1046/j.1365-2958.2002.03126.x;
RA Glaser P., Rusniok C., Buchrieser C., Chevalier F., Frangeul L., Msadek T.,
RA Zouine M., Couve E., Lalioui L., Poyart C., Trieu-Cuot P., Kunst F.;
RT "Genome sequence of Streptococcus agalactiae, a pathogen causing invasive
RT neonatal disease.";
RL Mol. Microbiol. 45:1499-1513(2002).
CC -!- FUNCTION: DNA-binding protein that represses the expression of many
CC genes that are induced as cells make the transition from rapid
CC exponential growth to stationary phase. It is a GTP-binding protein
CC that senses the intracellular GTP concentration as an indicator of
CC nutritional limitations. At low GTP concentration it no longer binds
CC GTP and stop to act as a transcriptional repressor. {ECO:0000255|HAMAP-
CC Rule:MF_00621}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00621}.
CC -!- SIMILARITY: Belongs to the CodY family. {ECO:0000255|HAMAP-
CC Rule:MF_00621}.
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DR EMBL; AL766852; CAD47378.1; -; Genomic_DNA.
DR RefSeq; WP_001133183.1; NC_004368.1.
DR AlphaFoldDB; P63846; -.
DR SMR; P63846; -.
DR STRING; 211110.gbs1719; -.
DR EnsemblBacteria; CAD47378; CAD47378; CAD47378.
DR GeneID; 66886521; -.
DR KEGG; san:gbs1719; -.
DR eggNOG; COG4465; Bacteria.
DR HOGENOM; CLU_089581_0_0_9; -.
DR OMA; MPFVNVD; -.
DR Proteomes; UP000000823; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR CDD; cd00090; HTH_ARSR; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR HAMAP; MF_00621; HTH_type_CodY; 1.
DR InterPro; IPR011991; ArsR-like_HTH.
DR InterPro; IPR014154; CodY.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR010312; GTP_sensing_CodY_N.
DR InterPro; IPR013198; GTP_sensing_HTH_CodY_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR40062; PTHR40062; 1.
DR Pfam; PF06018; CodY; 1.
DR Pfam; PF08222; HTH_CodY; 1.
DR PIRSF; PIRSF011572; GTP_sensing_CodY; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR TIGRFAMs; TIGR02787; codY_Gpos; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA-binding; GTP-binding; Nucleotide-binding; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..261
FT /note="GTP-sensing transcriptional pleiotropic repressor
FT CodY"
FT /id="PRO_0000213239"
FT DNA_BIND 206..225
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00621"
SQ SEQUENCE 261 AA; 28972 MW; 58E9251B260A9E46 CRC64;
MPNLLEKTRK ITSILQRSVD SLDAELPYNT MAAQLADIID CNACIINGGG NLLGYAMKYK
TNTDRVEEFF ETKQFPDYYV KSASRVYDTE ANLSVDNDLS IFPVETKENF QDGITTIAPI
YGGGMRLGTF IIWRNDKEFS DDDLILVEIA STVVGIQLLN LQTENLEENI RKQTAVTMAI
NTLSYSEMKA VAAILGELDG LEGRLTASVI ADRIGITRSV IVNALRKLES AGIIESRSLG
MKGTYLKVIN EGIFDKLKEY N