ID   CODY_STRPN              Reviewed;         262 AA.
AC   Q97PM1;
DT   28-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=GTP-sensing transcriptional pleiotropic repressor CodY {ECO:0000255|HAMAP-Rule:MF_00621};
GN   Name=codY {ECO:0000255|HAMAP-Rule:MF_00621}; OrderedLocusNames=SP_1584;
OS   Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=170187;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-334 / TIGR4;
RX   PubMed=11463916; DOI=10.1126/science.1061217;
RA   Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA   Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA   Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA   Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA   Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA   McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA   Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA   Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT   "Complete genome sequence of a virulent isolate of Streptococcus
RT   pneumoniae.";
RL   Science 293:498-506(2001).
CC   -!- FUNCTION: DNA-binding protein that represses the expression of many
CC       genes that are induced as cells make the transition from rapid
CC       exponential growth to stationary phase. It is a GTP-binding protein
CC       that senses the intracellular GTP concentration as an indicator of
CC       nutritional limitations. At low GTP concentration it no longer binds
CC       GTP and stop to act as a transcriptional repressor. {ECO:0000255|HAMAP-
CC       Rule:MF_00621}.
CC   -!- INTERACTION:
CC       Q97PM1; A0A0H2UNS2: SP_0443; NbExp=3; IntAct=EBI-6474032, EBI-6474029;
CC       Q97PM1; E7DN82; Xeno; NbExp=2; IntAct=EBI-6474032, EBI-3989787;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00621}.
CC   -!- SIMILARITY: Belongs to the CodY family. {ECO:0000255|HAMAP-
CC       Rule:MF_00621}.
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DR   EMBL; AE005672; AAK75670.1; -; Genomic_DNA.
DR   PIR; E95184; E95184.
DR   RefSeq; WP_000940729.1; NZ_AKVY01000001.1.
DR   AlphaFoldDB; Q97PM1; -.
DR   SMR; Q97PM1; -.
DR   IntAct; Q97PM1; 2.
DR   STRING; 170187.SP_1584; -.
DR   EnsemblBacteria; AAK75670; AAK75670; SP_1584.
DR   KEGG; spn:SP_1584; -.
DR   eggNOG; COG4465; Bacteria.
DR   OMA; MPFVNVD; -.
DR   PhylomeDB; Q97PM1; -.
DR   BioCyc; SPNE170187:G1FZB-1603-MON; -.
DR   Proteomes; UP000000585; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   CDD; cd00090; HTH_ARSR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00621; HTH_type_CodY; 1.
DR   InterPro; IPR011991; ArsR-like_HTH.
DR   InterPro; IPR014154; CodY.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR010312; GTP_sensing_CodY_N.
DR   InterPro; IPR013198; GTP_sensing_HTH_CodY_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR40062; PTHR40062; 1.
DR   Pfam; PF06018; CodY; 1.
DR   Pfam; PF08222; HTH_CodY; 1.
DR   PIRSF; PIRSF011572; GTP_sensing_CodY; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR02787; codY_Gpos; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; DNA-binding; GTP-binding; Nucleotide-binding; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..262
FT                   /note="GTP-sensing transcriptional pleiotropic repressor
FT                   CodY"
FT                   /id="PRO_0000213242"
FT   DNA_BIND        206..225
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00621"
SQ   SEQUENCE   262 AA;  29770 MW;  4BA04A5B0E8D0284 CRC64;
     MAHLLEKTRK ITSILKRSEE QLQDELPYNA ITRQLADIIH CNACIINSKG RLLGYFMRYK
     TNTDRVEQFF QTKIFPDDYV QGANMIYETE ANLPVEHDMS IFPIESRDDF PDGLTTIAPI
     HVSGIRLGSL IIWRNDKKFE DEDLVLVEIA STVVGIQLLN FQREEDEKNI RRRTAVTMAV
     NTLSYSELRA VSAILGELNG NEGKLTASVI ADRIGITRSV IVNALRKLES AGIIESRSLG
     MKGTYLKVLI SDIFEEVKKR DY