CODY_STRT2
ID CODY_STRT2 Reviewed; 261 AA.
AC Q5M305;
DT 21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 1.
DT 25-MAY-2022, entry version 112.
DE RecName: Full=GTP-sensing transcriptional pleiotropic repressor CodY {ECO:0000255|HAMAP-Rule:MF_00621};
GN Name=codY {ECO:0000255|HAMAP-Rule:MF_00621}; OrderedLocusNames=stu1635;
OS Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=264199;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-250 / LMG 18311;
RX PubMed=15543133; DOI=10.1038/nbt1034;
RA Bolotin A., Quinquis B., Renault P., Sorokin A., Ehrlich S.D.,
RA Kulakauskas S., Lapidus A., Goltsman E., Mazur M., Pusch G.D., Fonstein M.,
RA Overbeek R., Kyprides N., Purnelle B., Prozzi D., Ngui K., Masuy D.,
RA Hancy F., Burteau S., Boutry M., Delcour J., Goffeau A., Hols P.;
RT "Complete sequence and comparative genome analysis of the dairy bacterium
RT Streptococcus thermophilus.";
RL Nat. Biotechnol. 22:1554-1558(2004).
CC -!- FUNCTION: DNA-binding protein that represses the expression of many
CC genes that are induced as cells make the transition from rapid
CC exponential growth to stationary phase. It is a GTP-binding protein
CC that senses the intracellular GTP concentration as an indicator of
CC nutritional limitations. At low GTP concentration it no longer binds
CC GTP and stop to act as a transcriptional repressor. {ECO:0000255|HAMAP-
CC Rule:MF_00621}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00621}.
CC -!- SIMILARITY: Belongs to the CodY family. {ECO:0000255|HAMAP-
CC Rule:MF_00621}.
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DR EMBL; CP000023; AAV61238.1; -; Genomic_DNA.
DR RefSeq; WP_002951720.1; NC_006448.1.
DR AlphaFoldDB; Q5M305; -.
DR SMR; Q5M305; -.
DR STRING; 264199.stu1635; -.
DR EnsemblBacteria; AAV61238; AAV61238; stu1635.
DR GeneID; 66899381; -.
DR KEGG; stl:stu1635; -.
DR eggNOG; COG4465; Bacteria.
DR HOGENOM; CLU_089581_0_0_9; -.
DR OMA; MPFVNVD; -.
DR Proteomes; UP000001170; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR CDD; cd00090; HTH_ARSR; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR HAMAP; MF_00621; HTH_type_CodY; 1.
DR InterPro; IPR011991; ArsR-like_HTH.
DR InterPro; IPR014154; CodY.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR010312; GTP_sensing_CodY_N.
DR InterPro; IPR013198; GTP_sensing_HTH_CodY_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR40062; PTHR40062; 1.
DR Pfam; PF06018; CodY; 1.
DR Pfam; PF08222; HTH_CodY; 1.
DR PIRSF; PIRSF011572; GTP_sensing_CodY; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR TIGRFAMs; TIGR02787; codY_Gpos; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA-binding; GTP-binding; Nucleotide-binding;
KW Reference proteome; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..261
FT /note="GTP-sensing transcriptional pleiotropic repressor
FT CodY"
FT /id="PRO_0000213249"
FT DNA_BIND 206..225
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00621"
SQ SEQUENCE 261 AA; 28919 MW; 67A32124442726E1 CRC64;
MANLLDKTRK ITSILQRSVD SLEGDLPYNN MAAQLADIID CNAAIVNGGG ALLGFAMKYK
TNNDRVEKFF KAKQLPEEYI RGISRVYDTQ ENIGIDSDLT IFPVELKDDF PDGLTTIAPI
YGGGMRLGSF IIWRNDHDFV DDDLILVEIA STVVGLQLLH LQTENLEETI RKQTAINMAI
NTLSYSEIKA VSAILNELDG LEGRLTASVI ADRIGITRSV IVNALRKLES AGIIESRSLG
MKGTYLKVLN EGIYDKLKEY E