CODY_THEP3
ID CODY_THEP3 Reviewed; 250 AA.
AC B0K9V2;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 1.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=GTP-sensing transcriptional pleiotropic repressor CodY {ECO:0000255|HAMAP-Rule:MF_00621};
GN Name=codY {ECO:0000255|HAMAP-Rule:MF_00621}; OrderedLocusNames=Teth39_1261;
OS Thermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) (Clostridium
OS thermohydrosulfuricum).
OC Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC Thermoanaerobacteraceae; Thermoanaerobacter.
OX NCBI_TaxID=340099;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33223 / DSM 2355 / 39E;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Bruce D., Goodwin L., Saunders E., Brettin T.,
RA Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.,
RA Kyrpides N., Lykidis A., Hemme C., Fields M.W., He Z., Zhou J.,
RA Richardson P.;
RT "Complete sequence of Thermoanaerobacter pseudethanolicus 39E.";
RL Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA-binding protein that represses the expression of many
CC genes that are induced as cells make the transition from rapid
CC exponential growth to stationary phase. It is a GTP-binding protein
CC that senses the intracellular GTP concentration as an indicator of
CC nutritional limitations. At low GTP concentration it no longer binds
CC GTP and stop to act as a transcriptional repressor. {ECO:0000255|HAMAP-
CC Rule:MF_00621}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00621}.
CC -!- SIMILARITY: Belongs to the CodY family. {ECO:0000255|HAMAP-
CC Rule:MF_00621}.
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DR EMBL; CP000924; ABY94915.1; -; Genomic_DNA.
DR RefSeq; WP_003869175.1; NC_010321.1.
DR AlphaFoldDB; B0K9V2; -.
DR SMR; B0K9V2; -.
DR STRING; 340099.Teth39_1261; -.
DR EnsemblBacteria; ABY94915; ABY94915; Teth39_1261.
DR KEGG; tpd:Teth39_1261; -.
DR eggNOG; COG4465; Bacteria.
DR HOGENOM; CLU_089581_0_0_9; -.
DR OMA; MPFVNVD; -.
DR Proteomes; UP000002156; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR HAMAP; MF_00621; HTH_type_CodY; 1.
DR InterPro; IPR014154; CodY.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR010312; GTP_sensing_CodY_N.
DR InterPro; IPR013198; GTP_sensing_HTH_CodY_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR40062; PTHR40062; 1.
DR Pfam; PF06018; CodY; 1.
DR Pfam; PF08222; HTH_CodY; 1.
DR PIRSF; PIRSF011572; GTP_sensing_CodY; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR TIGRFAMs; TIGR02787; codY_Gpos; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA-binding; GTP-binding; Nucleotide-binding;
KW Reference proteome; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..250
FT /note="GTP-sensing transcriptional pleiotropic repressor
FT CodY"
FT /id="PRO_1000130461"
FT DNA_BIND 194..213
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00621"
SQ SEQUENCE 250 AA; 27852 MW; C8EFE57F05FA24B0 CRC64;
MSTLLEKTRK VNRILQKTGI QPVDFNEMAN ILKDVIEANV YILSRKGKVL GYSILKDYGN
DIFAQSKIIP EEYNDKLLRV TETLANDKGN LFKEDKVLSD LILTIVPVNG GGDRLGTLAL
SRGVKEFTDD DLILAEYGAT VVGLEILRSK NEEIEDEARK RAVVQMALGT LSYSELEAIK
NIFEELNGKE GLLVASKIAD KVGITRSVIV NALRKFESAG IIESRSLGMK GTHIRVLNDK
LLEELEKMKR
