COE1A_DANRE
ID COE1A_DANRE Reviewed; 591 AA.
AC A0A0R4IWI1; A0A0R4IW26; A0A0R4IWS1;
DT 16-JAN-2019, integrated into UniProtKB/Swiss-Prot.
DT 20-JAN-2016, sequence version 1.
DT 03-AUG-2022, entry version 39.
DE RecName: Full=Transcription factor COE1-A {ECO:0000250|UniProtKB:Q9UH73};
DE AltName: Full=Early B cell factor 1-A {ECO:0000250|UniProtKB:Q9UH73};
GN Name=ebf1a {ECO:0000303|PubMed:30045885};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000312|Proteomes:UP000000437};
RN [1] {ECO:0000312|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000305}
RP TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=30045885; DOI=10.1098/rsob.180043;
RA Chi Y., Huang Z., Chen Q., Xiong X., Chen K., Xu J., Zhang Y., Zhang W.;
RT "Loss of runx1 function results in B cell immunodeficiency but not T cell
RT in adult zebrafish.";
RL Open Biol. 8:0-0(2018).
CC -!- FUNCTION: Transcriptional activator. {ECO:0000250|UniProtKB:Q07802}.
CC -!- SUBUNIT: Forms either a homodimer or a heterodimer with a related
CC family member. {ECO:0000250|UniProtKB:Q07802}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|RuleBase:RU004489}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=A0A0R4IWI1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A0A0R4IWI1-2; Sequence=VSP_060020;
CC Name=3;
CC IsoId=A0A0R4IWI1-3; Sequence=VSP_060021;
CC -!- TISSUE SPECIFICITY: Detected in B cells. {ECO:0000269|PubMed:30045885}.
CC -!- INDUCTION: Up-regulated in B cells in response to runx1.
CC {ECO:0000269|PubMed:30045885}.
CC -!- SIMILARITY: Belongs to the COE family. {ECO:0000255|RuleBase:RU004489}.
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DR EMBL; AL929292; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CU012046; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CU019638; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CU468683; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_009289484.1; XM_009291209.2. [A0A0R4IWI1-2]
DR RefSeq; XP_009289485.1; XM_009291210.2. [A0A0R4IWI1-1]
DR AlphaFoldDB; A0A0R4IWI1; -.
DR SMR; A0A0R4IWI1; -.
DR STRING; 7955.ENSDARP00000028095; -.
DR PaxDb; A0A0R4IWI1; -.
DR Ensembl; ENSDART00000158634; ENSDARP00000139406; ENSDARG00000099849. [A0A0R4IWI1-3]
DR Ensembl; ENSDART00000170631; ENSDARP00000139773; ENSDARG00000099849. [A0A0R4IWI1-2]
DR Ensembl; ENSDART00000172171; ENSDARP00000139648; ENSDARG00000099849. [A0A0R4IWI1-1]
DR GeneID; 565310; -.
DR KEGG; dre:565310; -.
DR CTD; 565310; -.
DR ZFIN; ZDB-GENE-070112-292; ebf3a.
DR eggNOG; KOG3836; Eukaryota.
DR GeneTree; ENSGT00950000182859; -.
DR OMA; LCPSEGW; -.
DR OrthoDB; 817293at2759; -.
DR PhylomeDB; A0A0R4IWI1; -.
DR PRO; PR:A0A0R4IWI1; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 14.
DR Bgee; ENSDARG00000099849; Expressed in retina and 20 other tissues.
DR ExpressionAtlas; A0A0R4IWI1; baseline.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd11606; COE_DBD; 1.
DR CDD; cd01175; IPT_COE; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR Gene3D; 2.60.40.3180; -; 1.
DR InterPro; IPR032200; COE_DBD.
DR InterPro; IPR038173; COE_DBD_sf.
DR InterPro; IPR032201; COE_HLH.
DR InterPro; IPR038006; COE_IPT.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR003523; Transcription_factor_COE.
DR InterPro; IPR018350; Transcription_factor_COE_CS.
DR PANTHER; PTHR10747; PTHR10747; 1.
DR Pfam; PF16422; COE1_DBD; 1.
DR Pfam; PF16423; COE1_HLH; 1.
DR Pfam; PF01833; TIG; 1.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF81296; SSF81296; 1.
DR PROSITE; PS01345; COE; 1.
PE 2: Evidence at transcript level;
KW Activator; Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..591
FT /note="Transcription factor COE1-A"
FT /id="PRO_0000446087"
FT DOMAIN 262..344
FT /note="IPT/TIG"
FT /evidence="ECO:0000255"
FT ZN_FING 151..170
FT /note="C5-type"
FT /evidence="ECO:0000250|UniProtKB:Q07802"
FT REGION 63..66
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250|UniProtKB:Q07802"
FT REGION 197..204
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250|UniProtKB:Q07802"
FT REGION 236..239
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250|UniProtKB:Q07802"
FT REGION 454..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 163
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250|UniProtKB:Q07802"
FT SITE 172
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250|UniProtKB:Q07802"
FT VAR_SEQ 260
FT /note="A -> GES (in isoform 2)"
FT /id="VSP_060020"
FT VAR_SEQ 582..591
FT /note="VIPGMIVPPM -> GESGHRIYSLTLPPSPKKGKQKCENLTESR (in
FT isoform 3)"
FT /id="VSP_060021"
SQ SEQUENCE 591 AA; 64371 MW; 3A1205EC75ECCEFB CRC64;
MFGIQDSIQR SGSSMKEEPI GAGMNAVRTW MQGAGVLDAN TAAQSGVGLA RAHFEKQPPS
NLRKSNFFHF VLALYDRQGQ PVEIERTSFV GFVEKEKEST GEKTNNGIHY RLQLLYSNGI
RTEQDFYVRL IDSMTKQAII YEGQDKNPEM CRVLLTHEIM CSRCCDKKSC GNRNETPSDP
VIIDRFFLKF FLKCNQNCLK NAGNPRDMRR FQVVVSTTVS VDGHVLAVSD NMFVHNNSKH
GRRARRLDPS EGTPSYLEHA TPCIKAISPS EGWTTGGATV IIIGDNFFDG LQVIFGTMLV
WSELITPHAI RVQTPPRHIP GVVEVTLSYK SKQFCKGTPG RFIYTALNEP TIDYGFQRLQ
KVIPRHPGDP ERLPKEVILK RAADLVEALY GMPHNNQEII LKRAADIAEA LYNVPRGHNQ
LPGLTNSSVH SGMMGVNSFH SQLAVNVSDS TQAANQGFSR NTSSVSPHGY VPSTTPQQSS
YSTVSTSMNG YGNAGMTTLG GSPNFLNGSA ANSPYAIVPS SPTMASSTSL PSNCSSSSGI
FSFSPANMVS AVKQKSAFAP VVRPQASPPP TCTSANGNGL QVIPGMIVPP M
