ID   COE2A_XENLA             Reviewed;         575 AA.
AC   B7ZRJ4; O57515; O73741;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=Transcription factor coe2-A;
DE            Short=Xcoe-2;
DE            Short=Xcoe2;
DE   AltName: Full=Early B-cell factor 2-A;
DE            Short=EBF-2-A;
DE            Short=Xebf-2-A;
GN   Name=ebf2-a; Synonyms=coe2, coe2-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Embryonic head;
RA   Baldessari D., Consalez G.G.;
RL   Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a pivotal role in the transcriptional cascade that
CC       specifies primary neurons in embryos. Stabilizes the higher neural
CC       potential of selected progenitor cells that express neurog2/X-ngnr-1 by
CC       maintaining Delta-Notch signaling. Thus ensures the transition between
CC       neural competence and irreversible commitment to a neural fate. Also
CC       promotes neuronal differentiation by activating neurod1 expression,
CC       directly or indirectly (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the COE family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC15658.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF040993; AAC15658.1; ALT_INIT; mRNA.
DR   EMBL; BC170188; AAI70188.1; -; mRNA.
DR   RefSeq; NP_001079146.1; NM_001085677.1.
DR   AlphaFoldDB; B7ZRJ4; -.
DR   SMR; B7ZRJ4; -.
DR   GeneID; 373695; -.
DR   KEGG; xla:373695; -.
DR   CTD; 373695; -.
DR   Xenbase; XB-GENE-971141; ebf2.S.
DR   OMA; TCCERAG; -.
DR   OrthoDB; 817293at2759; -.
DR   Proteomes; UP000186698; Chromosome 3S.
DR   Bgee; 373695; Expressed in muscle tissue and 4 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   CDD; cd11606; COE_DBD; 1.
DR   CDD; cd01175; IPT_COE; 1.
DR   Gene3D; 2.60.40.10; -; 1.
DR   Gene3D; 2.60.40.3180; -; 1.
DR   InterPro; IPR032200; COE_DBD.
DR   InterPro; IPR038173; COE_DBD_sf.
DR   InterPro; IPR032201; COE_HLH.
DR   InterPro; IPR038006; COE_IPT.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR002909; IPT_dom.
DR   InterPro; IPR003523; Transcription_factor_COE.
DR   InterPro; IPR018350; Transcription_factor_COE_CS.
DR   PANTHER; PTHR10747; PTHR10747; 1.
DR   Pfam; PF16422; COE1_DBD; 1.
DR   Pfam; PF16423; COE1_HLH; 1.
DR   Pfam; PF01833; TIG; 1.
DR   SMART; SM00429; IPT; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
DR   PROSITE; PS01345; COE; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; Differentiation; DNA-binding;
KW   Metal-binding; Neurogenesis; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..575
FT                   /note="Transcription factor coe2-A"
FT                   /id="PRO_0000107831"
FT   DOMAIN          254..337
FT                   /note="IPT/TIG"
FT   ZN_FING         151..170
FT                   /note="C5-type"
FT                   /evidence="ECO:0000255"
FT   REGION          63..66
FT                   /note="Interaction with DNA"
FT                   /evidence="ECO:0000250"
FT   REGION          197..204
FT                   /note="Interaction with DNA"
FT                   /evidence="ECO:0000250"
FT   REGION          236..239
FT                   /note="Interaction with DNA"
FT                   /evidence="ECO:0000250"
FT   REGION          450..484
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            163
FT                   /note="Interaction with DNA"
FT                   /evidence="ECO:0000250"
FT   SITE            172
FT                   /note="Interaction with DNA"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        28
FT                   /note="R -> Q (in Ref. 1; AAC15658)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        573
FT                   /note="Missing (in Ref. 1; AAC15658)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   575 AA;  62884 MW;  5D265D42DD2F4B30 CRC64;
     MFGVQETLGR AGTALRDKAL GVGMDPIRSW VRNVGVVDAK VAAQSGVAVS RAHFEKQPPP
     NLRKSNFFHF VLALYDRQGQ PIEIERTAFV DFVENEKEFS TEKTNNGTHY KLQLLYSNGV
     RTEQDFYVRL IDSVTKQPIA YEGQNKNPEM CRVLLTHEVM CSRCCEKKSC GNRNETPSDP
     VIIDRFFLKF FLKCNQNCLK TAGNPRDMRR FQVVLSTTVN VDGHVLAVSD NMFVHNNSKH
     GRRARRLDPS EATPCIKAIS PSEGWTTGGA MVIIIGDNFF DGLQVVFGTM LVWSELITPH
     AIRVQTPPRH IPGVVEVTLS YKSKQFCKGA PGRFIYTALN EPTIDYGFQR LQKVVPRHPG
     DPERLAKEML LKRAADLVES LYGAPHNNQD IILKRAADIA EALYSVPRNH NQIPTLSSSP
     VHSGMMGINS YGGQLGISIS ESQANSQGYI RNTSSISPRG YSSSSTPQQS NYSTPSNSMN
     GYSNVPMSNL GVPGSPGFIN GSPTTSPYGI MPSSPPVGSS GSSSILPFSS TVFPSIKQKS
     AFAPVIRPQG SPSPACSSSN SNGFRAMTGL VVPPM