ID   2ABD_CHICK              Reviewed;         451 AA.
AC   Q5ZIY5;
DT   24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform;
DE   AltName: Full=PP2A subunit B isoform B55-delta;
DE   AltName: Full=PP2A subunit B isoform PR55-delta;
DE   AltName: Full=PP2A subunit B isoform R2-delta;
DE   AltName: Full=PP2A subunit B isoform delta;
GN   Name=PPP2R2D; ORFNames=RCJMB04_22l15;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: B regulatory subunit of protein phosphatase 2A (PP2A) that
CC       plays a key role in cell cycle by controlling mitosis entry and exit.
CC       The activity of PP2A complexes containing PPP2R2D (PR55-delta)
CC       fluctuate during the cell cycle: the activity is high in interphase and
CC       low in mitosis. During mitosis, activity of PP2A is inhibited via
CC       interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the
CC       PP2A complexes, the B regulatory subunits modulate substrate
CC       selectivity and catalytic activity, and also may direct the
CC       localization of the catalytic enzyme to a particular subcellular
CC       compartment (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: PP2A consists of a common heterodimeric core enzyme, composed
CC       of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant
CC       regulatory subunit (PR65 or subunit A), that associates with a variety
CC       of regulatory subunits. Proteins that associate with the core dimer
CC       include three families of regulatory subunits B (the R2/B/PR55/B55,
CC       R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable
CC       regulatory subunit, viral proteins, and cell signaling molecules.
CC       Interacts with ENSA (when phosphorylated at 'Ser-67') and ARPP19 (when
CC       phosphorylated at 'Ser-62'), leading to inhibit PP2A activity (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the phosphatase 2A regulatory subunit B family.
CC       {ECO:0000305}.
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DR   EMBL; AJ720649; CAG32308.1; -; mRNA.
DR   RefSeq; NP_001006507.1; NM_001006507.1.
DR   AlphaFoldDB; Q5ZIY5; -.
DR   SMR; Q5ZIY5; -.
DR   STRING; 9031.ENSGALP00000017035; -.
DR   PaxDb; Q5ZIY5; -.
DR   GeneID; 423970; -.
DR   KEGG; gga:423970; -.
DR   CTD; 55844; -.
DR   VEuPathDB; HostDB:geneid_423970; -.
DR   eggNOG; KOG1354; Eukaryota.
DR   InParanoid; Q5ZIY5; -.
DR   OrthoDB; 810409at2759; -.
DR   PhylomeDB; Q5ZIY5; -.
DR   PRO; PR:Q5ZIY5; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0000159; C:protein phosphatase type 2A complex; ISS:UniProtKB.
DR   GO; GO:0019888; F:protein phosphatase regulator activity; ISS:UniProtKB.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0010458; P:exit from mitosis; ISS:UniProtKB.
DR   GO; GO:0000278; P:mitotic cell cycle; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR000009; PP2A_PR55.
DR   InterPro; IPR018067; PP2A_PR55_CS.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR11871; PTHR11871; 1.
DR   PIRSF; PIRSF037309; PP2A_PR55; 1.
DR   PRINTS; PR00600; PP2APR55.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS01024; PR55_1; 1.
DR   PROSITE; PS01025; PR55_2; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Cytoplasm; Mitosis; Reference proteome; Repeat;
KW   WD repeat.
FT   CHAIN           1..451
FT                   /note="Serine/threonine-protein phosphatase 2A 55 kDa
FT                   regulatory subunit B delta isoform"
FT                   /id="PRO_0000071436"
FT   REPEAT          30..69
FT                   /note="WD 1"
FT   REPEAT          95..136
FT                   /note="WD 2"
FT   REPEAT          179..217
FT                   /note="WD 3"
FT   REPEAT          228..268
FT                   /note="WD 4"
FT   REPEAT          287..325
FT                   /note="WD 5"
FT   REPEAT          342..383
FT                   /note="WD 6"
FT   REPEAT          418..451
FT                   /note="WD 7"
SQ   SEQUENCE   451 AA;  52016 MW;  3AE312A5077A0BF6 CRC64;
     MAGVAGGGGN GNDFQWCFSQ VQGAVDEDVA EADIISTVEF NYSGDLLATG DKGGRVVIFQ
     REQENKSRPH SRGEYNVYST FQSHEPEFDY LKSLEIEEKI NKIRWLPQQN AAHFLLSTND
     KTIKLWKISE RDKRAEGYNL KDEDGRLRDP FKITALRVPI LKPMDLMVEA SPRRIFANAH
     TYHINSISVN SDHETYLSAD DLRINLWHLE ITDRSFNIVD IKPANMEELT EVITAAEFHP
     HHCNVFVYSS SKGTIRLCDM RSSALCDRHS KFFEEPEDPS SRSFFSEIIS SISDVKFSHS
     GRYMMTRDYL SVKVWDLNME NRPVETYQVH EYLRSKLCSL YENDCIFDKF ECCWNGSDGA
     IMTGSYNNFF RMFDRNTRRD ITLEASRESS KPRAILKPRK VCTGGKRKKD EINVDSLDFN
     KKILHTAWHP MENIIAVAAT NNLYIFQDKI N