COE2B_XENLA
ID COE2B_XENLA Reviewed; 580 AA.
AC B7ZRI2; O57515; O73741;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 03-AUG-2022, entry version 53.
DE RecName: Full=Transcription factor coe2-B {ECO:0000303|PubMed:9501982};
DE Short=Xcoe2 {ECO:0000303|PubMed:9501982};
DE AltName: Full=Early B-cell factor 2-B {ECO:0000250|UniProtKB:B7ZRJ4};
DE Short=EBF-2-B {ECO:0000250|UniProtKB:B7ZRJ4};
DE Short=Xebf-2-B;
GN Name=ebf2-b {ECO:0000312|EMBL:AAI70176.1};
GN Synonyms=coe2-b {ECO:0000303|PubMed:9501982};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAB96782.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RC TISSUE=Tail bud {ECO:0000269|PubMed:9501982};
RX PubMed=9501982; DOI=10.1016/s0960-9822(98)70084-3;
RA Dubois L., Bally-Cuif L., Crozatier M., Moreau J., Paquereau L.,
RA Vincent A.;
RT "XCoe2, a transcription factor of the Col/Olf-1/EBF family involved in the
RT specification of primary neurons in Xenopus.";
RL Curr. Biol. 8:199-209(1998).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAI70176.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May play a pivotal role in the transcriptional cascade that
CC specifies primary neurons in embryos. Stabilizes the higher neural
CC potential of selected progenitor cells that express neurog2/X-ngnr-1 by
CC maintaining Delta-Notch signaling. Thus ensures the transition between
CC neural competence and irreversible commitment to a neural fate. Also
CC promotes neuronal differentiation by activating neurod1 expression,
CC directly or indirectly. {ECO:0000269|PubMed:9501982}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=B7ZRI2-1; Sequence=Displayed;
CC Name=2 {ECO:0000269|PubMed:9501982};
CC IsoId=B7ZRI2-2; Sequence=VSP_040041;
CC -!- TISSUE SPECIFICITY: In embryos, expressed in precursors of primary
CC neurons. In adults, expressed at high levels in the brain, and at low
CC levels in the somatic muscles, testis, and possibly the spleen.
CC {ECO:0000269|PubMed:9501982}.
CC -!- DEVELOPMENTAL STAGE: Expression begins during primary neurogenesis at
CC the neural plate stage (stage 12) and accumulates at the tailbud stage.
CC Expressed after neurog2/X-ngnr-1 and before neurod1. Also expressed in
CC adults. {ECO:0000269|PubMed:9501982}.
CC -!- SIMILARITY: Belongs to the COE family. {ECO:0000255}.
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DR EMBL; AF041138; AAB96782.1; -; mRNA.
DR EMBL; BC170176; AAI70176.1; -; mRNA.
DR RefSeq; NP_001079147.1; NM_001085678.1.
DR RefSeq; XP_018106084.1; XM_018250595.1. [B7ZRI2-1]
DR RefSeq; XP_018106085.1; XM_018250596.1. [B7ZRI2-2]
DR AlphaFoldDB; B7ZRI2; -.
DR SMR; B7ZRI2; -.
DR GeneID; 373696; -.
DR KEGG; xla:373696; -.
DR CTD; 373696; -.
DR Xenbase; XB-GENE-6252857; ebf2.L.
DR OMA; YGTSGGM; -.
DR OrthoDB; 817293at2759; -.
DR Proteomes; UP000186698; Chromosome 3L.
DR Bgee; 373696; Expressed in neurula embryo and 5 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR CDD; cd11606; COE_DBD; 1.
DR CDD; cd01175; IPT_COE; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR Gene3D; 2.60.40.3180; -; 1.
DR InterPro; IPR032200; COE_DBD.
DR InterPro; IPR038173; COE_DBD_sf.
DR InterPro; IPR032201; COE_HLH.
DR InterPro; IPR038006; COE_IPT.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR003523; Transcription_factor_COE.
DR InterPro; IPR018350; Transcription_factor_COE_CS.
DR PANTHER; PTHR10747; PTHR10747; 1.
DR Pfam; PF16422; COE1_DBD; 1.
DR Pfam; PF16423; COE1_HLH; 1.
DR Pfam; PF01833; TIG; 1.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF81296; SSF81296; 1.
DR PROSITE; PS01345; COE; 1.
PE 2: Evidence at transcript level;
KW Activator; Alternative splicing; Developmental protein; Differentiation;
KW DNA-binding; Metal-binding; Neurogenesis; Nucleus; Reference proteome;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..580
FT /note="Transcription factor coe2-B"
FT /id="PRO_0000401104"
FT DOMAIN 259..341
FT /note="IPT/TIG"
FT /evidence="ECO:0000255"
FT ZN_FING 148..167
FT /note="C5-type"
FT /evidence="ECO:0000255"
FT REGION 60..63
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250"
FT REGION 194..201
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250"
FT REGION 233..236
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250"
FT REGION 455..492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 160
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250"
FT SITE 169
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250"
FT VAR_SEQ 249..256
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:9501982"
FT /id="VSP_040041"
FT CONFLICT 239
FT /note="R -> T (in Ref. 1; AAB96782)"
FT /evidence="ECO:0000305"
FT CONFLICT 291
FT /note="V -> E (in Ref. 1; AAB96782)"
FT /evidence="ECO:0000305"
FT CONFLICT 302
FT /note="I -> M (in Ref. 1; AAB96782)"
FT /evidence="ECO:0000305"
FT CONFLICT 489
FT /note="N -> K (in Ref. 1; AAB96782)"
FT /evidence="ECO:0000305"
FT CONFLICT 546..553
FT /note="AFAPVIRP -> GLCPCHTT (in Ref. 1; AAB96782)"
FT /evidence="ECO:0000305"
FT CONFLICT 571..579
FT /note="AMTGLVVPP -> ENLLKDSPAMRQGQYFAQCSNPSVGFW (in Ref. 1;
FT AAB96782)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 580 AA; 63486 MW; 9BA418B8FE621047 CRC64;
MFGVQETFGT ALRDKALGVG MDPVRSWVRN VGVVDAKVAA QSGVAVSRAH FEKQPPSNLR
KSNFFHFVLA LYDRQGQPIE IERTSFVDFV ENEKEFSTEK TNNGTHYKLQ LLYSNGVRTE
QDLYVRLIDS VTKQPISYEG QNKNPEMCRV LLTHEVMCSR CCEKKSCGNR NETPSDPVII
DRFFLKFFLK CNQNCLKTAG NPRDMRRFQV VLSTTVNVDG HVLAVSDNMF VHNNSKHGRR
ARRLDPSEGT DPSLEYATPC IKAISPSEGW TTGGAMVIII GDNFFDGLQV VFGTMLVWSE
LITPHAIRVQ TPPRHIPGVV EVTLSYKSKQ FCKGAPGRFI YTALNEPTID YGFQRLQKVI
PRHPGDPERM AKEMLLKRAA DLVEALYGTP HNNQDIILKR AADIAEALYS VPRNHNQIPA
LSSSPVHSGM MGINSYGGQL GVSISESQAN NQGYIRNTSS ISPRGYSSSS TPQQSNYSTP
SNSMNGYSNV PMSNLGVPGS PGFINGSPTT SPYGIMPSSP PVGSSGSSSI LPFSSSVFPS
IKQKSAFAPV IRPQGSPSPA CSSSNSNGFR AMTGLVVPPM
