ID   COE2_BOVIN              Reviewed;         575 AA.
AC   Q08DL5;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Transcription factor COE2;
DE   AltName: Full=Early B-cell factor 2;
DE            Short=EBF-2;
GN   Name=EBF2; Synonyms=COE2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal muscle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor that, in osteoblasts, activates the
CC       decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast
CC       differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1
CC       pathway. Recognizes variations of the palindromic sequence 5'-
CC       ATTCCCNNGGGAATT-3' (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Forms either a homodimer or a heterodimer with a related
CC       family member (By similarity). Interacts with SIX1 (By similarity).
CC       {ECO:0000250|UniProtKB:O08792}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the COE family. {ECO:0000305}.
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DR   EMBL; BC123680; AAI23681.1; -; mRNA.
DR   RefSeq; NP_001071407.1; NM_001077939.1.
DR   AlphaFoldDB; Q08DL5; -.
DR   SMR; Q08DL5; -.
DR   STRING; 9913.ENSBTAP00000014368; -.
DR   PaxDb; Q08DL5; -.
DR   Ensembl; ENSBTAT00000086147; ENSBTAP00000073790; ENSBTAG00000040390.
DR   GeneID; 519342; -.
DR   KEGG; bta:519342; -.
DR   CTD; 64641; -.
DR   VEuPathDB; HostDB:ENSBTAG00000040390; -.
DR   VGNC; VGNC:106720; EBF2.
DR   eggNOG; KOG3836; Eukaryota.
DR   GeneTree; ENSGT00950000182859; -.
DR   InParanoid; Q08DL5; -.
DR   OMA; YGTSGGM; -.
DR   OrthoDB; 817293at2759; -.
DR   Proteomes; UP000009136; Chromosome 8.
DR   Bgee; ENSBTAG00000040390; Expressed in intramuscular adipose tissue and 61 other tissues.
DR   ExpressionAtlas; Q08DL5; baseline.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd11606; COE_DBD; 1.
DR   CDD; cd01175; IPT_COE; 1.
DR   Gene3D; 2.60.40.10; -; 1.
DR   Gene3D; 2.60.40.3180; -; 1.
DR   InterPro; IPR032200; COE_DBD.
DR   InterPro; IPR038173; COE_DBD_sf.
DR   InterPro; IPR032201; COE_HLH.
DR   InterPro; IPR038006; COE_IPT.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR002909; IPT_dom.
DR   InterPro; IPR003523; Transcription_factor_COE.
DR   InterPro; IPR018350; Transcription_factor_COE_CS.
DR   PANTHER; PTHR10747; PTHR10747; 1.
DR   Pfam; PF16422; COE1_DBD; 1.
DR   Pfam; PF16423; COE1_HLH; 1.
DR   Pfam; PF01833; TIG; 1.
DR   SMART; SM00429; IPT; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
DR   PROSITE; PS01345; COE; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; DNA-binding; Metal-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..575
FT                   /note="Transcription factor COE2"
FT                   /id="PRO_0000282439"
FT   DOMAIN          253..336
FT                   /note="IPT/TIG"
FT   ZN_FING         150..169
FT                   /note="C5-type"
FT                   /evidence="ECO:0000255"
FT   REGION          62..65
FT                   /note="Interaction with DNA"
FT                   /evidence="ECO:0000250"
FT   REGION          196..203
FT                   /note="Interaction with DNA"
FT                   /evidence="ECO:0000250"
FT   REGION          235..238
FT                   /note="Interaction with DNA"
FT                   /evidence="ECO:0000250"
FT   REGION          441..479
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            162
FT                   /note="Interaction with DNA"
FT                   /evidence="ECO:0000250"
FT   SITE            171
FT                   /note="Interaction with DNA"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   575 AA;  62620 MW;  B1F8CB3529137449 CRC64;
     MFGIQDTLGR GPALKEKSLG AEMDSVRSWV RNVGVVDANV AAQSGVALSR AHFEKQPPSN
     LRKSNFFHFV LALYDRQGQP VEIERTAFVD FVENDKEQGN EKTNNGTHYK LQLLYSNGVR
     TEQDLYVRLI DSVTKQPIAY EGQNKNPEMC RVLLTHEVMC SRCCEKKSCG NRNETPSDPV
     IIDRFFLKFF LKCNQNCLKT AGNPRDMRRF QVVLSTTVNV DGHVLAVSDN MFVHNNSKHG
     RRARRLDPSE ATPCIKAISP SEGWTTGGAM VIIIGDNFFD GLQVVFGTML VWSELITPHA
     IRVQTPPRHI PGVVEVTLSY KSKQFCKGAP GRFIYTALNE PTIDYGFQRL QKVIPRHPGD
     PERLAKEMLL KRAADLVEAL YGTPHNNQDI ILKRAADIAE ALYSVPRNPS QIPALSSSPA
     HSGMMGINSY GSQLGVSISE STQGNNQGYI RNTSSISPRG YSSSSTPQQS NYSTSSNSMN
     GYSNVPMANL GVPGSPGFLN GSPTGSPYGI MSSSPTVGSS STSSILPFSS SVFPAVKQKS
     AFAPVIRPQG SPSPACSSGN GNGFRAMTGL VVPPM