COE2_DANRE
ID COE2_DANRE Reviewed; 579 AA.
AC O93375;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Transcription factor COE2;
GN Name=coe2;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9784615; DOI=10.1016/s0925-4773(98)00144-0;
RA Bally-Cuif L., Dubois L., Vincent A.;
RT "Molecular cloning of Zcoe2, the zebrafish homolog of Xenopus Xcoe2 and
RT mouse EBF-2, and its expression during primary neurogenesis.";
RL Mech. Dev. 77:85-90(1998).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: First detected at the 75% epiboly stage where it
CC covers the anterior neural plate. Widely expressed in the presumptive
CC mesencephalon and rhombomeres 1-4 until the 2-3-somite stage, with
CC expression persisting in ngn1-positive clusters. First detected in the
CC olfactory placodes at the 5-somite stage. In the spinal cord, detected
CC in ngn1-positive clusters of primary neuroblasts during the early
CC somite stages. Expression decreases in the spinal cord from the 30-
CC somite stage but persists in the olfactory bulb and regions of the
CC rhombencephalon and brain.
CC -!- SIMILARITY: Belongs to the COE family. {ECO:0000305}.
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DR EMBL; AF072657; AAC96103.1; -; mRNA.
DR AlphaFoldDB; O93375; -.
DR SMR; O93375; -.
DR STRING; 7955.ENSDARP00000009986; -.
DR PaxDb; O93375; -.
DR ZFIN; ZDB-GENE-990715-11; ebf2.
DR eggNOG; KOG3836; Eukaryota.
DR InParanoid; O93375; -.
DR PhylomeDB; O93375; -.
DR PRO; PR:O93375; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd11606; COE_DBD; 1.
DR CDD; cd01175; IPT_COE; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR Gene3D; 2.60.40.3180; -; 1.
DR InterPro; IPR032200; COE_DBD.
DR InterPro; IPR038173; COE_DBD_sf.
DR InterPro; IPR032201; COE_HLH.
DR InterPro; IPR038006; COE_IPT.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR003523; Transcription_factor_COE.
DR InterPro; IPR018350; Transcription_factor_COE_CS.
DR PANTHER; PTHR10747; PTHR10747; 1.
DR Pfam; PF16422; COE1_DBD; 1.
DR Pfam; PF16423; COE1_HLH; 1.
DR Pfam; PF01833; TIG; 1.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF81296; SSF81296; 1.
DR PROSITE; PS01345; COE; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..579
FT /note="Transcription factor COE2"
FT /id="PRO_0000107830"
FT DOMAIN 260..343
FT /note="IPT/TIG"
FT ZN_FING 149..168
FT /note="C5-type"
FT /evidence="ECO:0000255"
FT REGION 63..66
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250"
FT REGION 195..202
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250"
FT REGION 234..237
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250"
FT REGION 442..482
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 514..533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 549..579
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 161
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250"
FT SITE 170
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250"
SQ SEQUENCE 579 AA; 63528 MW; E2DD1919055EEA43 CRC64;
MFESQDHSIR TITELKVRTF EEEMDPVRSW VRNVGVIDAN IAAQSGVALS RAHFEKQPPS
NLRKSNFFHF VLALYDRNGQ PVEVERTSFV DFVEQDKTGE KTNNGTHYKL QLLYSNGVRT
EQDLYARLID SVTKQPISYE GQNKNPEMCR VLLTHEVMCS RCCEKKSCGN RNETPSDPVI
IDRFFLKFFL KCNQNCLKTA GNPRDMRRFQ VVLSTTVCVD GPVLAISDNM FVHNNSKHGR
RSRRMDPNET VENNMEYATP CIKAISPSEG WTTGGAMVIV IGENFFDGLQ VVFGSMLVWS
ELITPHAIRV QTPPRHIPGV VEVTLSYKSK QFCKGAPGRF IYTALNEPTI DYGFQRLQKL
IPRHPGDPDK LAKEMLLKRA ADVVESLYGN TTSNQDMLLK RAADIAEALY SVPRPHSQLQ
AMPSSPVHGS VMGLSSYPTQ LGVSIGEPGQ TSGQGYTRNS SSLSPRGYPS SSTPQQSAYG
SNGGMSYGAV PMSSLGVSGS PGFNSASPNS SPYAIMPSSP PGSSSSSSLL PFSSFPSSTK
QKSAFAPVLR PQGFPHHPSA KTSGGTSFRA MTGLVVPPM
