ID   COE2_XENTR              Reviewed;         575 AA.
AC   Q6P4K7;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Transcription factor coe2 {ECO:0000312|EMBL:AAH63360.1};
DE   AltName: Full=Early B-cell factor 2 {ECO:0000250|UniProtKB:B7ZRJ4};
DE            Short=EBF-2 {ECO:0000250|UniProtKB:B7ZRJ4};
GN   Name=ebf2 {ECO:0000312|Xenbase:XB-GENE-971136};
GN   Synonyms=coe2 {ECO:0000312|EMBL:AAH63360.1};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:AAH63360.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula {ECO:0000312|EMBL:AAH63360.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a pivotal role in the transcriptional cascade that
CC       specifies primary neurons in embryos. Stabilizes the higher neural
CC       potential of selected progenitor cells that express neurog2/X-ngnr-1 by
CC       maintaining Delta-Notch signaling. Thus ensures the transition between
CC       neural competence and irreversible commitment to a neural fate. Also
CC       promotes neuronal differentiation by activating neurod1 expression,
CC       directly or indirectly (By similarity). {ECO:0000250|UniProtKB:B7ZRI2}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the COE family. {ECO:0000255}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC063360; AAH63360.1; -; mRNA.
DR   RefSeq; NP_989200.1; NM_203869.1.
DR   AlphaFoldDB; Q6P4K7; -.
DR   SMR; Q6P4K7; -.
DR   STRING; 8364.ENSXETP00000022402; -.
DR   PaxDb; Q6P4K7; -.
DR   DNASU; 394808; -.
DR   GeneID; 394808; -.
DR   KEGG; xtr:394808; -.
DR   CTD; 64641; -.
DR   Xenbase; XB-GENE-971136; ebf2.
DR   eggNOG; KOG3836; Eukaryota.
DR   HOGENOM; CLU_016320_3_1_1; -.
DR   InParanoid; Q6P4K7; -.
DR   OrthoDB; 817293at2759; -.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd11606; COE_DBD; 1.
DR   CDD; cd01175; IPT_COE; 1.
DR   Gene3D; 2.60.40.10; -; 1.
DR   Gene3D; 2.60.40.3180; -; 1.
DR   InterPro; IPR032200; COE_DBD.
DR   InterPro; IPR038173; COE_DBD_sf.
DR   InterPro; IPR032201; COE_HLH.
DR   InterPro; IPR038006; COE_IPT.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR002909; IPT_dom.
DR   InterPro; IPR003523; Transcription_factor_COE.
DR   InterPro; IPR018350; Transcription_factor_COE_CS.
DR   PANTHER; PTHR10747; PTHR10747; 1.
DR   Pfam; PF16422; COE1_DBD; 1.
DR   Pfam; PF16423; COE1_HLH; 1.
DR   Pfam; PF01833; TIG; 1.
DR   SMART; SM00429; IPT; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
DR   PROSITE; PS01345; COE; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; Differentiation; DNA-binding;
KW   Metal-binding; Neurogenesis; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..575
FT                   /note="Transcription factor coe2"
FT                   /id="PRO_0000401105"
FT   DOMAIN          254..336
FT                   /note="IPT/TIG"
FT                   /evidence="ECO:0000255"
FT   ZN_FING         151..170
FT                   /note="C5-type"
FT                   /evidence="ECO:0000255"
FT   REGION          63..66
FT                   /note="Interaction with DNA"
FT                   /evidence="ECO:0000250"
FT   REGION          197..204
FT                   /note="Interaction with DNA"
FT                   /evidence="ECO:0000250"
FT   REGION          236..239
FT                   /note="Interaction with DNA"
FT                   /evidence="ECO:0000250"
FT   REGION          450..487
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            163
FT                   /note="Interaction with DNA"
FT                   /evidence="ECO:0000250"
FT   SITE            172
FT                   /note="Interaction with DNA"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   575 AA;  62805 MW;  859BE843378314BE CRC64;
     MFGVQDTLAR SGTALRDKAL GVGMDPVRSW VRNVGVVDAK VAAQSGVAVS RAHFEKQPPS
     NLRKSNFFHF VLALYDRQGQ PIEIERTAFV DFVENEKELS TEKTNNGTHY KLQLLYSNGV
     RTEQDLYVRL IDSVTKQPIA YEGQNKNPEM CRVLLTHEVM CSRCCEKKSC GNRNETPSDP
     VIIDRFFLKF FLKCNQNCLK TAGNPRDMRR FQVVLSTTVN VDGHVLAVSD NMFVHNNSKH
     GRRARRLDPS EATPCIKAIS PSEGWTTGGA MVIIIGDNFF DGLQVVFGTM LVWSELITPH
     AIRVQTPPRH IPGVVEVTLS YKSKQFCKGA PGRFIYTALN EPTIDYGFQR LQKVIPRHPG
     DPERLAKEML LKRAADLVEA LYGTPHNNQD IILKRAADIA EALYSVPRNH NQIPALSSSP
     VHSGMMGINS YGGQLGVSIS ESQANNQGYI RNTSSISPRG YSSSSTPQQS NYSTPSNSMN
     GYSNVPMSNL GVPGSPGFIN GSPTTSPYGI MPSSPPVGSS GSSSILPFSS SVFPSIKQKS
     AFAPVIRPQG SPSPACSSSN SNGFRAMTGL VVPPM