ID   COE3_XENLA              Reviewed;         598 AA.
AC   O73742;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   04-MAY-2001, sequence version 2.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Transcription factor COE3;
DE            Short=xCOE3;
DE   AltName: Full=Olf-1/EBF-like 2;
DE            Short=OE-2;
DE            Short=xEBF-3;
DE            Short=xOE-2;
GN   Name=coe3;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Embryonic head;
RX   PubMed=11336510; DOI=10.1006/dbio.2001.0230;
RA   Pozzoli O., Bosetti A., Croci L., Consalez G.G., Vetter M.L.;
RT   "Xebf3 is a regulator of neuronal differentiation during primary
RT   neurogenesis in Xenopus.";
RL   Dev. Biol. 233:495-512(2001).
CC   -!- FUNCTION: Acts as a transcriptional activator.
CC       {ECO:0000250|UniProtKB:Q9H4W6}.
CC   -!- SUBUNIT: Forms either a homodimer or a heterodimer with a related
CC       family member. {ECO:0000250|UniProtKB:O08791}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H4W6}.
CC   -!- SIMILARITY: Belongs to the COE family. {ECO:0000305}.
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DR   EMBL; AF040994; AAC15659.3; -; mRNA.
DR   RefSeq; NP_001083801.1; NM_001090332.1.
DR   AlphaFoldDB; O73742; -.
DR   SMR; O73742; -.
DR   GeneID; 399125; -.
DR   KEGG; xla:399125; -.
DR   CTD; 399125; -.
DR   Xenbase; XB-GENE-962547; ebf3.L.
DR   OrthoDB; 817293at2759; -.
DR   Proteomes; UP000186698; Chromosome 7L.
DR   Bgee; 399125; Expressed in internal ear and 6 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   CDD; cd11606; COE_DBD; 1.
DR   CDD; cd01175; IPT_COE; 1.
DR   Gene3D; 2.60.40.10; -; 1.
DR   Gene3D; 2.60.40.3180; -; 1.
DR   InterPro; IPR032200; COE_DBD.
DR   InterPro; IPR038173; COE_DBD_sf.
DR   InterPro; IPR032201; COE_HLH.
DR   InterPro; IPR038006; COE_IPT.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR002909; IPT_dom.
DR   InterPro; IPR003523; Transcription_factor_COE.
DR   InterPro; IPR018350; Transcription_factor_COE_CS.
DR   PANTHER; PTHR10747; PTHR10747; 1.
DR   Pfam; PF16422; COE1_DBD; 1.
DR   Pfam; PF16423; COE1_HLH; 1.
DR   Pfam; PF01833; TIG; 1.
DR   SMART; SM00429; IPT; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
DR   PROSITE; PS01345; COE; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; DNA-binding; Metal-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..598
FT                   /note="Transcription factor COE3"
FT                   /id="PRO_0000107834"
FT   DOMAIN          264..347
FT                   /note="IPT/TIG"
FT   ZN_FING         151..170
FT                   /note="C5-type"
FT                   /evidence="ECO:0000255"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          63..66
FT                   /note="Interaction with DNA"
FT                   /evidence="ECO:0000250"
FT   REGION          197..204
FT                   /note="Interaction with DNA"
FT                   /evidence="ECO:0000250"
FT   REGION          236..239
FT                   /note="Interaction with DNA"
FT                   /evidence="ECO:0000250"
FT   REGION          452..483
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            163
FT                   /note="Interaction with DNA"
FT                   /evidence="ECO:0000250"
FT   SITE            172
FT                   /note="Interaction with DNA"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   598 AA;  65344 MW;  AC61383E4CD58B0F CRC64;
     MFGIQENIPR GGTTMKEEPL GGGMNPVRSW MHTAGVVDAN TAAQSGVGLA RAHFEKQPPS
     NLRKSNFFHF VLAMYDRQGQ PVEIERTTFV DFVEKDKEPN SEKTNNGIHY KLQLLYSNGV
     RTEQDLYVRL IDSMTKQAII YEGQDKNPEM CRVLLTHEIM CSRCCDKKSC GNRNETPSDP
     VIIDRFFLKF FLKCNQNCLK NAGNPRDMRR FQVVVSTTVN VDGHVLAVSD NMFVHNNSKH
     GRRARRLDPS EGTAPSYLEN VATPCIKAIS PSEGWTTGGA TVIIIGDNFF DGLQVVFGTM
     LVWSELITPH AIRVQTPPRH IPGVVEVTLS YKSKQFCKGA PGRFVYTALN EPTIDYGFQR
     LQKVIPRHPG DPERLPKEVL LKRAADLVEA LYGMPHNNQE IILKRAADIA EALYSVPRNH
     NQIPSLANTP SHSGMMGVNS FSSQLAVNVS ETSQANDQVG YSRNTSSVSP RGYVPSSTPQ
     QSNYNTVSNS MNGYGNAGMP NLGVPGSPGF LNGSSANSPY GIVPSSPTMA ASSVTLPSNC
     SSTHGIFSFS PANVISAVKQ KSAFAPVVRP QASPPPSCTS ANGNGLQDMY FSPTFSKS