ID   COF2_XENLA              Reviewed;         167 AA.
AC   Q5XHH8;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Cofilin-2;
GN   Name=cfl2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Controls reversibly actin polymerization and depolymerization
CC       in a pH-sensitive manner. It has the ability to bind G- and F-actin in
CC       a 1:1 ratio of cofilin to actin. It is the major component of
CC       intranuclear and cytoplasmic actin rods (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus matrix {ECO:0000250}. Cytoplasm,
CC       cytoskeleton {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the actin-binding proteins ADF family.
CC       {ECO:0000305}.
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DR   EMBL; BC084079; AAH84079.1; -; mRNA.
DR   RefSeq; NP_001088171.1; NM_001094702.1.
DR   AlphaFoldDB; Q5XHH8; -.
DR   SMR; Q5XHH8; -.
DR   MaxQB; Q5XHH8; -.
DR   DNASU; 494995; -.
DR   GeneID; 494995; -.
DR   KEGG; xla:494995; -.
DR   CTD; 494995; -.
DR   Xenbase; XB-GENE-6078566; cfl2.L.
DR   OMA; ECKYAIY; -.
DR   OrthoDB; 1370477at2759; -.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Bgee; 494995; Expressed in heart and 15 other tissues.
DR   GO; GO:0015629; C:actin cytoskeleton; IEA:InterPro.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0051015; F:actin filament binding; ISS:UniProtKB.
DR   GO; GO:0030042; P:actin filament depolymerization; ISS:UniProtKB.
DR   CDD; cd11286; ADF_cofilin_like; 1.
DR   Gene3D; 3.40.20.10; -; 1.
DR   InterPro; IPR002108; ADF-H.
DR   InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR   InterPro; IPR017904; ADF/Cofilin.
DR   PANTHER; PTHR11913; PTHR11913; 1.
DR   Pfam; PF00241; Cofilin_ADF; 1.
DR   PRINTS; PR00006; COFILIN.
DR   SMART; SM00102; ADF; 1.
DR   PROSITE; PS51263; ADF_H; 1.
PE   2: Evidence at transcript level;
KW   Actin-binding; Cytoplasm; Cytoskeleton; Nucleus; Reference proteome.
FT   CHAIN           1..167
FT                   /note="Cofilin-2"
FT                   /id="PRO_0000214911"
FT   DOMAIN          4..153
FT                   /note="ADF-H"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00599"
FT   MOTIF           30..34
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   167 AA;  18858 MW;  798B3B40D43A6B2C CRC64;
     MASGVTVNDE VIKVFNEMKV RKSSTPEEIK KRKKAVLFCL SPDKKEIIVE ETKQILVGDI
     GEAVQDPYRT FVNLLPLDDC RYGLYDATYE TKESKKEDLV FIFWAPDNAP LKSKMIYASS
     KDAIKKKFTG IKHEWQVNGL DDIKDRCTLA DKLGGNVVVS LEGVPLK