COF2_XENTR
ID COF2_XENTR Reviewed; 167 AA.
AC Q5U4Y2;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Cofilin-2;
GN Name=cfl2;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Controls reversibly actin polymerization and depolymerization
CC in a pH-sensitive manner. It has the ability to bind G- and F-actin in
CC a 1:1 ratio of cofilin to actin. It is the major component of
CC intranuclear and cytoplasmic actin rods (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus matrix {ECO:0000250}. Cytoplasm,
CC cytoskeleton {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the actin-binding proteins ADF family.
CC {ECO:0000305}.
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DR EMBL; BC084909; AAH84909.1; -; mRNA.
DR RefSeq; NP_001011156.1; NM_001011156.2.
DR AlphaFoldDB; Q5U4Y2; -.
DR SMR; Q5U4Y2; -.
DR STRING; 8364.ENSXETP00000026893; -.
DR PaxDb; Q5U4Y2; -.
DR Ensembl; ENSXETT00000026893; ENSXETP00000026893; ENSXETG00000012301.
DR GeneID; 496574; -.
DR KEGG; xtr:496574; -.
DR CTD; 1073; -.
DR Xenbase; XB-GENE-1002956; cfl2.
DR eggNOG; KOG1735; Eukaryota.
DR HOGENOM; CLU_094004_0_0_1; -.
DR InParanoid; Q5U4Y2; -.
DR OMA; ECKYAIY; -.
DR OrthoDB; 1370477at2759; -.
DR PhylomeDB; Q5U4Y2; -.
DR TreeFam; TF328601; -.
DR Proteomes; UP000008143; Chromosome 8.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000012301; Expressed in heart and 10 other tissues.
DR ExpressionAtlas; Q5U4Y2; baseline.
DR GO; GO:0015629; C:actin cytoskeleton; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.
DR GO; GO:0051015; F:actin filament binding; ISS:UniProtKB.
DR GO; GO:0030042; P:actin filament depolymerization; ISS:UniProtKB.
DR GO; GO:0030043; P:actin filament fragmentation; IBA:GO_Central.
DR GO; GO:0051014; P:actin filament severing; IBA:GO_Central.
DR CDD; cd11286; ADF_cofilin_like; 1.
DR Gene3D; 3.40.20.10; -; 1.
DR InterPro; IPR002108; ADF-H.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR017904; ADF/Cofilin.
DR PANTHER; PTHR11913; PTHR11913; 1.
DR Pfam; PF00241; Cofilin_ADF; 1.
DR PRINTS; PR00006; COFILIN.
DR SMART; SM00102; ADF; 1.
DR PROSITE; PS51263; ADF_H; 1.
PE 2: Evidence at transcript level;
KW Actin-binding; Cytoplasm; Cytoskeleton; Nucleus; Reference proteome.
FT CHAIN 1..167
FT /note="Cofilin-2"
FT /id="PRO_0000214912"
FT DOMAIN 4..153
FT /note="ADF-H"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00599"
FT MOTIF 30..34
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
SQ SEQUENCE 167 AA; 18827 MW; 8DDA7E54842F6A86 CRC64;
MASGVTVNDE VIKVFNEMKV RKSSTPEEIK KRKKAVLFCL SPDKKEIIVE ETKQILVGDI
GEAVPDPYRT FVNLLPLDDC RYGLYDATYE TKESKKEDLV FIFWAPDNAP LKSKMIYASS
KDAIKKKFTG IKHEWQVNGL DDIKDRCTLA DKLGGNVVVS LEGVPLK