COFA_DICDI
ID COFA_DICDI Reviewed; 137 AA.
AC P0DJ26; P54706; Q54DU6;
DT 19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT 19-OCT-2011, sequence version 1.
DT 25-MAY-2022, entry version 65.
DE RecName: Full=Cofilin-1A;
GN Name=cofA; Synonyms=cof1, dcof1; ORFNames=DDB_G0277833;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=AX2;
RX PubMed=7738034; DOI=10.1074/jbc.270.18.10923;
RA Aizawa H., Sutoh K., Tsubuki S., Kawashima S., Ishii A., Yahara I.;
RT "Identification, characterization, and intracellular distribution of
RT cofilin in Dictyostelium discoideum.";
RL J. Biol. Chem. 270:10923-10932(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=AX2;
RX PubMed=16926386; DOI=10.1074/mcp.m600113-mcp200;
RA Gotthardt D., Blancheteau V., Bosserhoff A., Ruppert T., Delorenzi M.,
RA Soldati T.;
RT "Proteomics fingerprinting of phagosome maturation and evidence for the
RT role of a Galpha during uptake.";
RL Mol. Cell. Proteomics 5:2228-2243(2006).
CC -!- FUNCTION: Controls reversibly actin polymerization and depolymerization
CC in a pH-sensitive manner. It has the ability to bind G- and F-actin in
CC a 1:1 ratio of cofilin to actin. It is the major component of
CC intranuclear and cytoplasmic actin rods (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus matrix {ECO:0000250}. Cytoplasm,
CC cytoskeleton {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the actin-binding proteins ADF family.
CC {ECO:0000305}.
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DR EMBL; D37980; BAA07198.1; -; Genomic_DNA.
DR EMBL; AAFI02000023; EAL68089.1; -; Genomic_DNA.
DR RefSeq; XP_629776.1; XM_629774.1.
DR RefSeq; XP_642259.1; XM_637167.1.
DR AlphaFoldDB; P0DJ26; -.
DR SMR; P0DJ26; -.
DR IntAct; P0DJ26; 1.
DR STRING; 44689.DDB0201631; -.
DR PaxDb; P0DJ26; -.
DR EnsemblProtists; EAL68089; EAL68089; DDB_G0277833.
DR GeneID; 8621468; -.
DR GeneID; 8628452; -.
DR KEGG; ddi:DDB_G0277833; -.
DR KEGG; ddi:DDB_G0291970; -.
DR dictyBase; DDB_G0277833; cofA.
DR eggNOG; KOG1735; Eukaryota.
DR HOGENOM; CLU_094004_3_2_1; -.
DR InParanoid; P0DJ26; -.
DR OMA; ITFYSWS; -.
DR PhylomeDB; P0DJ26; -.
DR PRO; PR:P0DJ26; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0015629; C:actin cytoskeleton; IDA:dictyBase.
DR GO; GO:0005737; C:cytoplasm; IDA:dictyBase.
DR GO; GO:0061836; C:intranuclear rod; IDA:dictyBase.
DR GO; GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IDA:dictyBase.
DR GO; GO:0045335; C:phagocytic vesicle; HDA:dictyBase.
DR GO; GO:0001726; C:ruffle; IDA:dictyBase.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0003785; F:actin monomer binding; TAS:dictyBase.
DR GO; GO:0051017; P:actin filament bundle assembly; IMP:dictyBase.
DR GO; GO:0030042; P:actin filament depolymerization; IDA:dictyBase.
DR GO; GO:0051014; P:actin filament severing; IDA:dictyBase.
DR GO; GO:0048870; P:cell motility; IMP:dictyBase.
DR GO; GO:0006972; P:hyperosmotic response; IMP:dictyBase.
DR GO; GO:0009617; P:response to bacterium; HEP:dictyBase.
DR CDD; cd11286; ADF_cofilin_like; 1.
DR Gene3D; 3.40.20.10; -; 1.
DR InterPro; IPR002108; ADF-H.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR017904; ADF/Cofilin.
DR PANTHER; PTHR11913; PTHR11913; 1.
DR Pfam; PF00241; Cofilin_ADF; 1.
DR PRINTS; PR00006; COFILIN.
DR SMART; SM00102; ADF; 1.
DR PROSITE; PS51263; ADF_H; 1.
PE 1: Evidence at protein level;
KW Actin-binding; Cytoplasm; Cytoskeleton; Nucleus; Reference proteome.
FT CHAIN 1..137
FT /note="Cofilin-1A"
FT /id="PRO_0000214913"
FT DOMAIN 2..135
FT /note="ADF-H"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00599"
SQ SEQUENCE 137 AA; 15224 MW; 0C0B0673354F46F3 CRC64;
MSSGIALAPN CVSTFNDLKL GRKYGGIIYR ISDDSKEIIV DSTLPAGCSF DEFTKCLPEN
ECRYVVLDYQ YKEEGAQKSK ICFVAWCPDT ANIKKKMMAT SSKDSLRKAC VGIQVEIQGT
DASEVKDSCF YEKCTKI
