ID   2ABD_DANRE              Reviewed;         447 AA.
AC   Q6NY64;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform;
DE   AltName: Full=PP2A subunit B isoform B55-delta;
DE   AltName: Full=PP2A subunit B isoform PR55-delta;
DE   AltName: Full=PP2A subunit B isoform R2-delta;
DE   AltName: Full=PP2A subunit B isoform delta;
GN   Name=ppp2r2d; ORFNames=zgc:76887;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: B regulatory subunit of protein phosphatase 2A (PP2A) that
CC       plays a key role in cell cycle by controlling mitosis entry and exit.
CC       The activity of PP2A complexes containing PPP2R2D (PR55-delta)
CC       fluctuate during the cell cycle: the activity is high in interphase and
CC       low in mitosis. During mitosis, activity of PP2A is inhibited via
CC       interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the
CC       PP2A complexes, the B regulatory subunits modulate substrate
CC       selectivity and catalytic activity, and also may direct the
CC       localization of the catalytic enzyme to a particular subcellular
CC       compartment (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: PP2A consists of a common heterodimeric core enzyme, composed
CC       of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant
CC       regulatory subunit (PR65 or subunit A), that associates with a variety
CC       of regulatory subunits. Proteins that associate with the core dimer
CC       include three families of regulatory subunits B (the R2/B/PR55/B55,
CC       R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable
CC       regulatory subunit, viral proteins, and cell signaling molecules.
CC       Interacts with ENSA (when phosphorylated at 'Ser-74') and ARPP19 (when
CC       phosphorylated at 'Ser-62'), leading to inhibit PP2A activity (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the phosphatase 2A regulatory subunit B family.
CC       {ECO:0000305}.
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DR   EMBL; BC066723; AAH66723.1; -; mRNA.
DR   RefSeq; NP_998045.1; NM_212880.1.
DR   AlphaFoldDB; Q6NY64; -.
DR   SMR; Q6NY64; -.
DR   STRING; 7955.ENSDARP00000099721; -.
DR   PaxDb; Q6NY64; -.
DR   Ensembl; ENSDART00000172175; ENSDARP00000131091; ENSDARG00000102009.
DR   GeneID; 405816; -.
DR   KEGG; dre:405816; -.
DR   CTD; 55844; -.
DR   ZFIN; ZDB-GENE-040426-2086; ppp2r2d.
DR   eggNOG; KOG1354; Eukaryota.
DR   GeneTree; ENSGT00950000182864; -.
DR   InParanoid; Q6NY64; -.
DR   OrthoDB; 810409at2759; -.
DR   PhylomeDB; Q6NY64; -.
DR   PRO; PR:Q6NY64; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 12.
DR   Bgee; ENSDARG00000102009; Expressed in mature ovarian follicle and 26 other tissues.
DR   ExpressionAtlas; Q6NY64; baseline.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0000159; C:protein phosphatase type 2A complex; ISS:UniProtKB.
DR   GO; GO:0019888; F:protein phosphatase regulator activity; ISS:UniProtKB.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0010458; P:exit from mitosis; ISS:UniProtKB.
DR   GO; GO:0000278; P:mitotic cell cycle; ISS:UniProtKB.
DR   GO; GO:0007520; P:myoblast fusion; IMP:ZFIN.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR000009; PP2A_PR55.
DR   InterPro; IPR018067; PP2A_PR55_CS.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR11871; PTHR11871; 1.
DR   PIRSF; PIRSF037309; PP2A_PR55; 1.
DR   PRINTS; PR00600; PP2APR55.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS01024; PR55_1; 1.
DR   PROSITE; PS01025; PR55_2; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Cytoplasm; Mitosis; Reference proteome; Repeat;
KW   WD repeat.
FT   CHAIN           1..447
FT                   /note="Serine/threonine-protein phosphatase 2A 55 kDa
FT                   regulatory subunit B delta isoform"
FT                   /id="PRO_0000408324"
FT   REPEAT          26..65
FT                   /note="WD 1"
FT   REPEAT          91..132
FT                   /note="WD 2"
FT   REPEAT          175..213
FT                   /note="WD 3"
FT   REPEAT          224..264
FT                   /note="WD 4"
FT   REPEAT          283..321
FT                   /note="WD 5"
FT   REPEAT          338..379
FT                   /note="WD 6"
FT   REPEAT          414..447
FT                   /note="WD 7"
SQ   SEQUENCE   447 AA;  51716 MW;  9FC2E4A0EFE0E6E1 CRC64;
     MAGVGGGNDF QWCFSQVKGA IDEDVAEADI ISTVEFNYSG ELLATGDKGG RVVIFQREQE
     SKNRPLSRGE YNVYSTFQSH EPEFDYLKSL EIEEKINKIR WLPQQNAAHF LLSTNDKTIK
     LWKISERDKR AEGYNLKDED GRLRDPFRIT SLRVPVLMPM DLMVEASPRR IFANAHTYHI
     NSISVNSDYE TYLSADDLRI NLWHLEITDR SFNIVDIKPA NMEELTEVIT AAECHPHQCN
     VFVYSSSKGT IRLCDMRAAA LCDRHSKFFE EPEDPSSRSF FSEIISSISD VKFSHSGRYM
     MTRDYLSVKV WDLNMENRPV ETYQVHEYLR SKLCSLYEND CIFDKFECCW NGSDSAIMTG
     SYNNFFRMFD RNTRRDITLE ASRESSKPRA MLKPRKVCTG GKRKKDEISV DSLDFNKKIL
     HTAWHPKENV IAVAATNNLY IFQDKMN