ID   ACPB_BACAN              Reviewed;         482 AA.
AC   Q9RMX9;
DT   02-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 113.
DE   RecName: Full=Capsule synthesis positive regulator AcpB;
GN   Name=acpB; OrderedLocusNames=pXO2-53, BXB0060, GBAA_pXO2_0060;
OS   Bacillus anthracis.
OG   Plasmid pXO2.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=1392;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Pasteur;
RX   PubMed=10475962; DOI=10.1046/j.1365-2672.1999.00883.x;
RA   Okinaka R.T., Cloud K., Hampton O., Hoffmaster A., Hill K.K., Keim P.,
RA   Koehler T., Lamke G., Kumano S., Manter D., Martinez Y., Ricke D.,
RA   Svensson R., Jackson P.J.;
RT   "Sequence, assembly and analysis of pXO1 and pXO2.";
RL   J. Appl. Microbiol. 87:261-262(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Ames / isolate Florida / A2012;
RX   PubMed=12004073; DOI=10.1126/science.1071837;
RA   Read T.D., Salzberg S.L., Pop M., Shumway M.F., Umayam L., Jiang L.,
RA   Holtzapple E., Busch J.D., Smith K.L., Schupp J.M., Solomon D., Keim P.,
RA   Fraser C.M.;
RT   "Comparative genome sequencing for discovery of novel polymorphisms in
RT   Bacillus anthracis.";
RL   Science 296:2028-2033(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ames ancestor;
RX   PubMed=18952800; DOI=10.1128/jb.01347-08;
RA   Ravel J., Jiang L., Stanley S.T., Wilson M.R., Decker R.S., Read T.D.,
RA   Worsham P., Keim P.S., Salzberg S.L., Fraser-Liggett C.M., Rasko D.A.;
RT   "The complete genome sequence of Bacillus anthracis Ames 'Ancestor'.";
RL   J. Bacteriol. 191:445-446(2009).
RN   [4]
RP   FUNCTION, AND INDUCTION.
RX   PubMed=14702298; DOI=10.1128/jb.186.2.307-315.2004;
RA   Drysdale M., Bourgogne A., Hilsenbeck S.G., Koehler T.M.;
RT   "atxA controls Bacillus anthracis capsule synthesis via acpA and a newly
RT   discovered regulator, acpB.";
RL   J. Bacteriol. 186:307-315(2004).
CC   -!- FUNCTION: AcpB and AcpA regulate cap gene expression and capsule
CC       synthesis. {ECO:0000269|PubMed:14702298}.
CC   -!- INDUCTION: Transcriptionally regulated by AtxA. Transcription is also
CC       positively controlled by carbonic acid and CO(2).
CC       {ECO:0000269|PubMed:14702298}.
CC   -!- SIMILARITY: Belongs to the AtxA/AcpA family. {ECO:0000305}.
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DR   EMBL; AF188935; AAF13658.1; -; Genomic_DNA.
DR   EMBL; AE011191; AAM26216.1; -; Genomic_DNA.
DR   EMBL; AE017335; AAT28990.2; -; Genomic_DNA.
DR   RefSeq; NP_053208.1; NC_002146.1.
DR   RefSeq; WP_000409765.1; NZ_VTZL01000009.1.
DR   AlphaFoldDB; Q9RMX9; -.
DR   SMR; Q9RMX9; -.
DR   EnsemblBacteria; AAT28990; AAT28990; GBAA_pXO2_0060.
DR   GeneID; 45025362; -.
DR   KEGG; bar:GBAA_pXO2_0060; -.
DR   HOGENOM; CLU_044310_0_0_9; -.
DR   OMA; NFYIPGI; -.
DR   Proteomes; UP000000594; Plasmid pXO2.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR013199; HTH_Mga_DNA-bd_dom.
DR   InterPro; IPR007737; Mga_HTH.
DR   InterPro; IPR011608; PRD.
DR   InterPro; IPR036634; PRD_sf.
DR   Pfam; PF08280; HTH_Mga; 1.
DR   Pfam; PF05043; Mga; 1.
DR   SUPFAM; SSF63520; SSF63520; 1.
DR   PROSITE; PS51372; PRD_2; 2.
PE   2: Evidence at transcript level;
KW   Activator; Capsule biogenesis/degradation; Plasmid; Reference proteome;
KW   Repeat; Transcription; Transcription regulation; Virulence.
FT   CHAIN           1..482
FT                   /note="Capsule synthesis positive regulator AcpB"
FT                   /id="PRO_0000219547"
FT   DOMAIN          165..270
FT                   /note="PRD 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00704"
FT   DOMAIN          283..395
FT                   /note="PRD 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00704"
SQ   SEQUENCE   482 AA;  57211 MW;  E473BD1FDCA73315 CRC64;
     MEKDIKRQIQ ILEIITSEEK WFTTIEISKI LRCCNKTIMK DISFIKDFLP EDWHIKIKKG
     KGVRIYLPYN KHRNEITFLL FRESLTFRIL QHLFERETKT IATLAERLYI QVPSILPALK
     RVENYLKKFG LKLRKKPLRL EGDEVRIMIM YLDLYLKSYN DTEWPFEKLK KEVIFQYLGT
     LEESLGISLH VVSKRHLSFF IAILLKRKQQ GYKVQLNRKF LYFNTETPDY VKIGRIFEKL
     EREFGVSLTV QDKILLTISI KSSKYVYKDI NKEKEESVQY FKEGNLSIYE LVKDFINSLE
     EKLKVDLISD EEFIFALVDY FKRTIYHLQY LCMFERPQKQ TIQYMQTEHS ETFSAVKEVY
     TEFVKKNEIA DYVSVEEIAK VTMYIEASRL RYTSNYKKVL LVTGESESWA EYLAATLAKR
     FGDKIQISTV FFAKKSDHDV NADFIISTIP LDLGSTPIIC INSIPTERDY TNIQYYLDLQ
     DG