ID   ACPC_CAUVN              Reviewed;          86 AA.
AC   A0A0H3C7L7;
DT   25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT   16-SEP-2015, sequence version 1.
DT   03-AUG-2022, entry version 26.
DE   RecName: Full=Probable acyl carrier protein CCNA_01221 {ECO:0000305};
GN   OrderedLocusNames=CCNA_01221 {ECO:0000312|EMBL:ACL94686.1};
OS   Caulobacter vibrioides (strain NA1000 / CB15N) (Caulobacter crescentus).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=565050;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NA1000 / CB15N;
RX   PubMed=20472802; DOI=10.1128/jb.00255-10;
RA   Marks M.E., Castro-Rojas C.M., Teiling C., Du L., Kapatral V.,
RA   Walunas T.L., Crosson S.;
RT   "The genetic basis of laboratory adaptation in Caulobacter crescentus.";
RL   J. Bacteriol. 192:3678-3688(2010).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=NA1000 / CB15N;
RX   PubMed=33063925; DOI=10.1111/1462-2920.15280;
RA   Olea-Ozuna R.J., Poggio S., Bergstroem E., Quiroz-Rocha E.,
RA   Garcia-Soriano D.A., Sahonero-Canavesi D.X., Padilla-Gomez J.,
RA   Martinez-Aguilar L., Lopez-Lara I.M., Thomas-Oates J., Geiger O.;
RT   "Five structural genes required for ceramide synthesis in Caulobacter and
RT   for bacterial survival.";
RL   Environ. Microbiol. 23:143-159(2021).
RN   [3]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=NA1000 / CB15N;
RX   PubMed=34969973; DOI=10.1038/s41589-021-00948-7;
RA   Stankeviciute G., Tang P., Ashley B., Chamberlain J.D., Hansen M.E.B.,
RA   Coleman A., D'Emilia R., Fu L., Mohan E.C., Nguyen H., Guan Z.,
RA   Campopiano D.J., Klein E.A.;
RT   "Convergent evolution of bacterial ceramide synthesis.";
RL   Nat. Chem. Biol. 18:305-312(2022).
CC   -!- FUNCTION: Involved in de novo bacterial ceramide synthesis.
CC       {ECO:0000269|PubMed:33063925, ECO:0000269|PubMed:34969973}.
CC   -!- PATHWAY: Lipid metabolism; sphingolipid metabolism. {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: Deletion mutant cannot form bacterial ceramide
CC       (PubMed:33063925, PubMed:34969973). Mutants are impaired in growth at
CC       elevated temperatures but are resistant towards the antibiotic
CC       polymyxin B (PubMed:33063925). {ECO:0000269|PubMed:33063925,
CC       ECO:0000269|PubMed:34969973}.
CC   -!- SIMILARITY: Belongs to the acyl carrier protein (ACP) family.
CC       {ECO:0000305}.
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DR   EMBL; CP001340; ACL94686.1; -; Genomic_DNA.
DR   RefSeq; WP_012640163.1; NC_011916.1.
DR   RefSeq; YP_002516594.1; NC_011916.1.
DR   EnsemblBacteria; ACL94686; ACL94686; CCNA_01221.
DR   GeneID; 7333614; -.
DR   KEGG; ccs:CCNA_01221; -.
DR   PATRIC; fig|565050.3.peg.1203; -.
DR   HOGENOM; CLU_108696_13_0_5; -.
DR   OMA; FVMEIED; -.
DR   OrthoDB; 1943389at2; -.
DR   PhylomeDB; A0A0H3C7L7; -.
DR   UniPathway; UPA00222; -.
DR   Proteomes; UP000001364; Chromosome.
DR   GO; GO:0006665; P:sphingolipid metabolic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.10.1200.10; -; 1.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   Pfam; PF00550; PP-binding; 1.
DR   SUPFAM; SSF47336; SSF47336; 1.
DR   PROSITE; PS50075; CARRIER; 1.
PE   3: Inferred from homology;
KW   Lipid metabolism; Phosphopantetheine; Phosphoprotein; Reference proteome.
FT   CHAIN           1..86
FT                   /note="Probable acyl carrier protein CCNA_01221"
FT                   /id="PRO_0000455455"
FT   DOMAIN          6..83
FT                   /note="Carrier"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT   MOD_RES         43
FT                   /note="O-(pantetheine 4'-phosphoryl)serine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
SQ   SEQUENCE   86 AA;  9423 MW;  FDB81579381E0CCF CRC64;
     MIRMDTVTDL SLREIGVAAT KVLGRAVEVR AESHIGRDLA VDSLALMNII MELEDTFDIS
     IPLDRLASVE TAGDLSKLIN DLRTRA