COG1_ARATH
ID COG1_ARATH Reviewed; 1068 AA.
AC Q9FFF3;
DT 13-NOV-2019, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Conserved oligomeric Golgi complex subunit 1 {ECO:0000303|PubMed:27448097};
DE Short=COG complex subunit 1 {ECO:0000303|PubMed:27448097};
DE AltName: Full=Component of oligomeric Golgi complex 1 {ECO:0000303|PubMed:27448097};
GN Name=COG1 {ECO:0000303|PubMed:27448097};
GN OrderedLocusNames=At5g16300 {ECO:0000312|Araport:AT5G16300};
GN ORFNames=MQK4.2 {ECO:0000312|EMBL:BAB09597.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9330910; DOI=10.1093/dnares/4.3.215;
RA Sato S., Kotani H., Nakamura Y., Kaneko T., Asamizu E., Fukami M.,
RA Miyajima N., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. I. Sequence
RT features of the 1.6 Mb regions covered by twenty physically assigned P1
RT clones.";
RL DNA Res. 4:215-230(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP INTERACTION WITH COG3 AND COG8, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=27448097; DOI=10.1371/journal.pgen.1006140;
RA Tan X., Cao K., Liu F., Li Y., Li P., Gao C., Ding Y., Lan Z., Shi Z.,
RA Rui Q., Feng Y., Liu Y., Zhao Y., Wu C., Zhang Q., Li Y., Jiang L., Bao Y.;
RT "Arabidopsis COG complex subunits COG3 and COG8 modulate golgi morphology,
RT vesicle trafficking homeostasis and are essential for pollen tube growth.";
RL PLoS Genet. 12:E1006140-E1006140(2016).
CC -!- FUNCTION: Required for normal Golgi function.
CC {ECO:0000250|UniProtKB:P53079}.
CC -!- SUBUNIT: Component of the conserved oligomeric Golgi complex which is
CC composed of eight different subunits and is required for normal Golgi
CC morphology and localization (Probable). Interacts with COG3 and COG8
CC (PubMed:27448097). {ECO:0000269|PubMed:27448097,
CC ECO:0000305|PubMed:27448097}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:Q8WTW3}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:Q8WTW3}; Cytoplasmic side
CC {ECO:0000250|UniProtKB:Q8WTW3}.
CC -!- SIMILARITY: Belongs to the COG1 family. {ECO:0000305}.
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DR EMBL; AB005242; BAB09597.1; -; Genomic_DNA.
DR EMBL; CP002688; AED92274.1; -; Genomic_DNA.
DR RefSeq; NP_197134.1; NM_121635.4.
DR AlphaFoldDB; Q9FFF3; -.
DR STRING; 3702.AT5G16300.1; -.
DR iPTMnet; Q9FFF3; -.
DR PaxDb; Q9FFF3; -.
DR PRIDE; Q9FFF3; -.
DR ProteomicsDB; 175324; -.
DR EnsemblPlants; AT5G16300.1; AT5G16300.1; AT5G16300.
DR GeneID; 831491; -.
DR Gramene; AT5G16300.1; AT5G16300.1; AT5G16300.
DR KEGG; ath:AT5G16300; -.
DR Araport; AT5G16300; -.
DR TAIR; locus:2171302; AT5G16300.
DR eggNOG; KOG2033; Eukaryota.
DR InParanoid; Q9FFF3; -.
DR OrthoDB; 221637at2759; -.
DR PhylomeDB; Q9FFF3; -.
DR PRO; PR:Q9FFF3; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FFF3; baseline and differential.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017119; C:Golgi transport complex; IEA:InterPro.
DR GO; GO:0009536; C:plastid; HDA:TAIR.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR033370; COG1.
DR PANTHER; PTHR31658; PTHR31658; 1.
PE 1: Evidence at protein level;
KW Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW Transport.
FT CHAIN 1..1068
FT /note="Conserved oligomeric Golgi complex subunit 1"
FT /id="PRO_0000448524"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1068 AA; 118802 MW; D696E592DD4B991C CRC64;
MRMSSASAGE YRPSAVSLSS NGGGQRDAES LFRTKPMSEI RIVESATRKN IEDKKEELRQ
LVGTRYRDLI DSADSIVHMK SLCESISANI SSIHGNIRSL SSSSVAETPK LASLNPVRVN
VYGIACRVKY LVDTPENIWG CLDESMFLEA AGRYMRAQHV QQRLIKLEGC GGGVAEVDQS
KLLANFPLLE HQWQIVESFK AQISQRSHER LLDPGLGLGA YVDALTAVAV VDELDPEQVL
ELFLDSRKTW ILQKLNACTG EDAGEVVLVF CDVLSVIQVT VGQVGELFLQ ALTDMPLFYK
TILSTPPASQ LFGGIPNPEE EVELWKSFRD KLESVMLILD KNDVSKSCLT WLRECGGQIV
GKVSGKHLIE AIVTGAELGS AEKLIRETMD SKDVLRGSLD WLKSVFGSEV ELPWNRIREL
VLGDDLNLWD EIFEKAFVER MKSIIDSKFE NLTKAVNVAD SVHAYSEITG EKINFQAYLN
RPSTGGGVWF IEPNSKKVGL ISGNKSSPEE SDFQSCLTAY FGPEVSQMRD AVDRRCHSVL
EDLLSFFESE KAGPRLKDLA PYVQNKCYDS VSALLADVDK ELEFLCAAVK KENKDSEAIP
PAIIIEKSLF MGRLLFALLN HSKHVPLILG SPRLWCRETM TAVSDKLSSL LRQPRFSSNT
PATADSPGKQ LHTDLRKQTS LAVAALLGAE EKTSPKFEEL NRTMRDLCIK AHTLWIKWLS
DELSAILLRD LRSDDGLSAT TPLRGWEETI VKQEQDESQS ELKISLPSLP SLYMISFLCR
ASEEIHRIGG HVLDRSILQK FASSLLEKIT IIYEDFLSAR EASEPQISEK GVLQILLDLR
FAADVLSGGD TSTNVETPKS TINRSAYRRR QDQQKTKLVN RGRIDGVTSQ LTQKLDPIDW
LTYEPYLWEN EKQSYLRHAV LFGFFVQLNR MYTDTAQKLS INIESNIMPC STVPRFKYLP
ISAPALSSRS TNKVSIPVTS NDASARNSWK AFTNGEQSQT SDLEENSNFG VAFKSFMQES
TLKLGSILTD GQVGIFKDRS AAAMSTFGDI LPAQAAGLLS SFTNTRSE
