COG1_DICDI
ID COG1_DICDI Reviewed; 1449 AA.
AC Q54ZB3;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 78.
DE RecName: Full=Conserved oligomeric Golgi complex subunit 1;
DE Short=COG complex subunit 1;
DE AltName: Full=Component of oligomeric Golgi complex 1;
GN Name=cog1; ORFNames=DDB_G0277691;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Required for normal Golgi function. {ECO:0000250}.
CC -!- SUBUNIT: Component of the conserved oligomeric Golgi complex which is
CC composed of eight different subunits and is required for normal Golgi
CC morphology and localization. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the COG1 family. {ECO:0000305}.
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DR EMBL; AAFI02000021; EAL68603.1; -; Genomic_DNA.
DR RefSeq; XP_642524.1; XM_637432.1.
DR AlphaFoldDB; Q54ZB3; -.
DR SMR; Q54ZB3; -.
DR STRING; 44689.DDB0237853; -.
DR PaxDb; Q54ZB3; -.
DR EnsemblProtists; EAL68603; EAL68603; DDB_G0277691.
DR GeneID; 8621150; -.
DR KEGG; ddi:DDB_G0277691; -.
DR dictyBase; DDB_G0277691; cog1.
DR eggNOG; KOG2033; Eukaryota.
DR HOGENOM; CLU_251438_0_0_1; -.
DR InParanoid; Q54ZB3; -.
DR OMA; PEVIWRS; -.
DR Reactome; R-DDI-6807878; COPI-mediated anterograde transport.
DR Reactome; R-DDI-6811438; Intra-Golgi traffic.
DR PRO; PR:Q54ZB3; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017119; C:Golgi transport complex; IEA:InterPro.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR033370; COG1.
DR PANTHER; PTHR31658; PTHR31658; 1.
PE 3: Inferred from homology;
KW Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW Transport.
FT CHAIN 1..1449
FT /note="Conserved oligomeric Golgi complex subunit 1"
FT /id="PRO_0000341680"
FT REGION 503..529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 916..960
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1303..1338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1401..1422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 933..960
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1449 AA; 165186 MW; BE19BE7468AAEF96 CRC64;
MAFNQMRSSG STTDLNRLNS SSISGGGNIN ISNGGYGNQQ LNAILSPIKS SSLSSMSNSS
SYSNLNTLSS SKSFNSLTLI ENQNDTTTTT STNNGAISEQ YQQLLSMIPK YQTKQYESDV
KILFERNTPE QMKQMEFKKR SEIEDMKSQL RNLIGNKYRD LVEGSDAIVK MKKSTELISD
NLSLMQSELK QFSEKRNHFR KGVSQDNLKL NKEKEIQKKI SIFSKYCKFL IDIPEVIWRS
LDSNDYFEVC VFFLKSKYLY SKITNENNLE IKRLLSKLTI IEKQWISMKQ FPIKTIGYSK
LFLNESTSRI IGTPIEKYIG SLSTLILFEK KSIKETFNEF LLSRRSVLFN SILSKDTNRP
IQQTIEKMFQ FLKMSIYYIM VLFYPRKYQT NNNNNNDQPE EEEQDDEKLI SNDYQSKISK
FKSNLQQYTS SLSSMSSTTT TTNSPTFESK MINKPVSEKE LNQLPTLNFT SSILESTFNW
RSPYLKECLK FYKDVSNGEL SINSSGSQQG DDYQDINTNN NNSNNNNSGI DSQDIEYSLI
EFDNFNSNFI FKRTSEWIEE IIEDFKLNLV QKFLIDIKSA KELSSLRSEI FDFILDFKNI
VPFIQPPQTN SLSSSNSSIN SIASPSVSLT SSTSSPIIAT TKATVLTTPT PTPTPTPTTP
ISWNRMFSII CGKDMKYFLN IFEDIFLVKS ESIIMDSFSR INLSKIQSDI FSQIKSEDKN
FSEFLWFYNQ DDPIQSIKNK TNGITPSNEL FLTKINQLYN NIKSDFIYLL NDNNINNINI
NNNNNNNNNN NNNNNNNRSM IITSQPKNLI KINEILIKEY MKKSFYKSLN EFTTSTQDRI
DQLILLNKNK TTSGTTTSTN LKKDEILFIS KLSKIFYKHI VNNPNLYFLN SLNIFDTTNI
SNCSTSFSKS NSINILDTIS SPPQPPPSPT HSSPSIQRHT NNNNNNNNNN NNTSPIINNN
NNNSEILKES LPIIDKLKQQ FYYGCIVWVN EFVGDYSQIL KQDLFNHDWN DSDRIKTWEK
HIIQIESNGH NHNNDANDGG GDDDATVNGV NEHSTIIYIP YQTSPFITSY LMSISLEISK
FSLNTIDKNI LRFIIESITL NLFNIVNDLL STSSTSTTAS TSNLTSNNTT TTIKFNKEGY
IQLLIDLKYI GFILFGRELN SSSSKKPTSQ PTSNVIIKDS IFKKAKSHYQ SIISTKNNVD
ENIELQKQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQEQ LSNNIVYTFN QIIELVEKNL
DPIDLAFYNS YIVKFIDQTY SKTLTLFGNF VYLHKSIVKP EKKQSINGGQ QSPPLATTSS
NGISGGKGIQ QQQQQQSDLP NPMQLLKTNT KFQLFSIDTI QTITDAIATA PTTIPSSTSN
SIQSSANNSA IASPISTIDY RNQQQQQQNN TNQQSLPSIL SPTSASSTIN TFSFMGKKIS
DLMYNTTKK
