COG1_DROME
ID COG1_DROME Reviewed; 886 AA.
AC Q9VGC3;
DT 15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Conserved oligomeric Golgi complex subunit 1;
DE Short=COG complex subunit 1;
DE AltName: Full=Component of oligomeric Golgi complex 1 {ECO:0000312|FlyBase:FBgn0037998};
GN Name=Cog1 {ECO:0000312|FlyBase:FBgn0037998};
GN ORFNames=CG4848 {ECO:0000312|FlyBase:FBgn0037998};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-839, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- FUNCTION: Required for normal Golgi function. {ECO:0000250}.
CC -!- SUBUNIT: Component of the conserved oligomeric Golgi complex which is
CC composed of eight different subunits and is required for normal Golgi
CC morphology and localization. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}; Cytoplasmic side
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the COG1 family. {ECO:0000305}.
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DR EMBL; AE014297; AAF54760.1; -; Genomic_DNA.
DR EMBL; AY058448; AAL13677.1; -; mRNA.
DR RefSeq; NP_001262497.1; NM_001275568.1.
DR RefSeq; NP_650162.1; NM_141905.3.
DR AlphaFoldDB; Q9VGC3; -.
DR SMR; Q9VGC3; -.
DR BioGRID; 66592; 3.
DR DIP; DIP-23267N; -.
DR IntAct; Q9VGC3; 3.
DR STRING; 7227.FBpp0082093; -.
DR iPTMnet; Q9VGC3; -.
DR PaxDb; Q9VGC3; -.
DR PRIDE; Q9VGC3; -.
DR DNASU; 41479; -.
DR EnsemblMetazoa; FBtr0082624; FBpp0082093; FBgn0037998.
DR EnsemblMetazoa; FBtr0334597; FBpp0306664; FBgn0037998.
DR GeneID; 41479; -.
DR KEGG; dme:Dmel_CG4848; -.
DR UCSC; CG4848-RA; d. melanogaster.
DR CTD; 9382; -.
DR FlyBase; FBgn0037998; Cog1.
DR VEuPathDB; VectorBase:FBgn0037998; -.
DR eggNOG; KOG2033; Eukaryota.
DR GeneTree; ENSGT00390000017136; -.
DR HOGENOM; CLU_012605_0_0_1; -.
DR InParanoid; Q9VGC3; -.
DR OrthoDB; 221637at2759; -.
DR PhylomeDB; Q9VGC3; -.
DR Reactome; R-DME-6807878; COPI-mediated anterograde transport.
DR Reactome; R-DME-6811438; Intra-Golgi traffic.
DR SignaLink; Q9VGC3; -.
DR BioGRID-ORCS; 41479; 1 hit in 1 CRISPR screen.
DR GenomeRNAi; 41479; -.
DR PRO; PR:Q9VGC3; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0037998; Expressed in salivary gland body primordium (Drosophila) and 30 other tissues.
DR ExpressionAtlas; Q9VGC3; baseline and differential.
DR Genevisible; Q9VGC3; DM.
DR GO; GO:0005794; C:Golgi apparatus; ISS:FlyBase.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017119; C:Golgi transport complex; IDA:FlyBase.
DR GO; GO:0007030; P:Golgi organization; ISS:FlyBase.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; ISS:FlyBase.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR033370; COG1.
DR PANTHER; PTHR31658; PTHR31658; 1.
PE 1: Evidence at protein level;
KW Golgi apparatus; Membrane; Phosphoprotein; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..886
FT /note="Conserved oligomeric Golgi complex subunit 1"
FT /id="PRO_0000213493"
FT REGION 834..886
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 844..879
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 839
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
SQ SEQUENCE 886 AA; 99716 MW; 2DE97D584476FBC8 CRC64;
MTANLLNLNV DTLFEQHSVS EIDEVHKKIQ SVVENKREEL RTHVGERYRD LLQAADTIAA
MQTSAGTLME QVRHVQANCR SLNEQQLLGF QSTANASAKD AALKERNAGK KLQTYYGTMA
QIKLLTALPE LIWTHLDNDR FYAATELFIF SRHISTGLQL DGQSALMQKL PVARKQWEIL
RPFHVTIKQA ILTALEREEL LQEMTVDCLQ SLLLLDKSDL STVLKSFLNL RSSAFLNCLQ
SGPSEPRRVK DRILASLNVL NSTVELLDKC LLGYSLLFSR LEECASSTCP PSINRMESSE
RQLVHLLPEI IAGFKPQFDV PQLTPEQLGS SLQQWLDKMN ALAAAHLQQV FALVTNMQTI
QDIKSAARTN GRPDFVRLEQ QLHLKRSQLD FYARKYVPLI NARVREIIRS SWASAMKLTY
EQVLLLIEAG QSQPPLQIWR EQSDDLPLSL AAALSDQPKR LANRTKGYDG ATIELCKRFD
SHLADIVQEL NVMLQEQTTR AEDKVSLIEF LRETAEEQLT EYLSNLKGLE LRERPALLLA
LRNSLALVEL CPNLKLCFCQ PSSWRQWTDN SAGLGIEHWQ RICGLIEKEM LSFWLVIVDD
VLAGHNCEEK LPKVINHEVV LSDFALWQTL TLEQRDEDQE QSVQSTIRIP SQPRLSLQTY
LHQLIQALNS VVPQTLPPKV LQAFIQRLIG KLLCHYEGLA HAECTKASQN IALQLYFDLK
FLERVFAISR EERTLYDQIH AQQNQLRDYI DPFDFELFAE HITAHVSRAA SRLQGELGVL
TPSAAAPSQG AAAASSLAHE ADPNVLCLSS SGSTSLWFPL LPIVMPQAAG RVTSAERKSP
IQEPVEKTAT TTPTRKSGGN GARKGDSSKS KSSAASFFGM SQEWFR
