COG1_MOUSE
ID COG1_MOUSE Reviewed; 980 AA.
AC Q9Z160; Q6P567;
DT 30-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 3.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Conserved oligomeric Golgi complex subunit 1;
DE Short=COG complex subunit 1;
DE AltName: Full=Component of oligomeric Golgi complex 1;
DE AltName: Full=Low density lipoprotein receptor defect B-complementing protein;
GN Name=Cog1; Synonyms=Ldlb;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ;
RX PubMed=9927668; DOI=10.1073/pnas.96.3.915;
RA Chatterton J.E., Hirsch D., Schwartz J.J., Bickel P.E., Rosenberg R.D.,
RA Lodish H.F., Krieger M.;
RT "Expression cloning of LDLB, a gene essential for normal Golgi function and
RT assembly of the ldlCp complex.";
RL Proc. Natl. Acad. Sci. U.S.A. 96:915-920(1999).
RN [2]
RP SEQUENCE REVISION.
RA Oka T., Chatterton J.E., Krieger M.;
RL Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, Liver, Lung, Pancreas, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [6]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-598, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic fibroblast;
RX PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT pathways.";
RL Mol. Cell 50:919-930(2013).
CC -!- FUNCTION: Required for normal Golgi function.
CC -!- SUBUNIT: Component of the conserved oligomeric Golgi complex which is
CC composed of eight different subunits and is required for normal Golgi
CC morphology and localization. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}; Cytoplasmic side
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the COG1 family. {ECO:0000305}.
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DR EMBL; AF109377; AAD13780.2; -; mRNA.
DR EMBL; AK034636; BAE43288.1; -; mRNA.
DR EMBL; BC063056; AAH63056.1; -; mRNA.
DR CCDS; CCDS25599.1; -.
DR RefSeq; NP_038609.3; NM_013581.3.
DR AlphaFoldDB; Q9Z160; -.
DR SMR; Q9Z160; -.
DR BioGRID; 201132; 4.
DR STRING; 10090.ENSMUSP00000018805; -.
DR iPTMnet; Q9Z160; -.
DR PhosphoSitePlus; Q9Z160; -.
DR EPD; Q9Z160; -.
DR MaxQB; Q9Z160; -.
DR PaxDb; Q9Z160; -.
DR PRIDE; Q9Z160; -.
DR ProteomicsDB; 283342; -.
DR Antibodypedia; 31901; 132 antibodies from 28 providers.
DR DNASU; 16834; -.
DR Ensembl; ENSMUST00000018805; ENSMUSP00000018805; ENSMUSG00000018661.
DR GeneID; 16834; -.
DR KEGG; mmu:16834; -.
DR UCSC; uc007mer.2; mouse.
DR CTD; 9382; -.
DR MGI; MGI:1333873; Cog1.
DR VEuPathDB; HostDB:ENSMUSG00000018661; -.
DR eggNOG; KOG2033; Eukaryota.
DR GeneTree; ENSGT00390000017136; -.
DR HOGENOM; CLU_012605_0_0_1; -.
DR InParanoid; Q9Z160; -.
DR OMA; CSWFRHL; -.
DR OrthoDB; 221637at2759; -.
DR PhylomeDB; Q9Z160; -.
DR TreeFam; TF314678; -.
DR Reactome; R-MMU-6807878; COPI-mediated anterograde transport.
DR Reactome; R-MMU-6811438; Intra-Golgi traffic.
DR Reactome; R-MMU-6811440; Retrograde transport at the Trans-Golgi-Network.
DR BioGRID-ORCS; 16834; 23 hits in 73 CRISPR screens.
DR ChiTaRS; Cog1; mouse.
DR PRO; PR:Q9Z160; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q9Z160; protein.
DR Bgee; ENSMUSG00000018661; Expressed in external carotid artery and 246 other tissues.
DR ExpressionAtlas; Q9Z160; baseline and differential.
DR Genevisible; Q9Z160; MM.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017119; C:Golgi transport complex; ISO:MGI.
DR GO; GO:0070085; P:glycosylation; ISO:MGI.
DR GO; GO:0007030; P:Golgi organization; ISO:MGI.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0000301; P:retrograde transport, vesicle recycling within Golgi; ISO:MGI.
DR InterPro; IPR033370; COG1.
DR PANTHER; PTHR31658; PTHR31658; 1.
PE 1: Evidence at protein level;
KW Acetylation; Golgi apparatus; Membrane; Phosphoprotein; Protein transport;
KW Reference proteome; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q8WTW3"
FT CHAIN 2..980
FT /note="Conserved oligomeric Golgi complex subunit 1"
FT /id="PRO_0000213492"
FT REGION 923..950
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q8WTW3"
FT MOD_RES 7
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8WTW3"
FT MOD_RES 598
FT /note="N6-acetyllysine"
FT /evidence="ECO:0007744|PubMed:23806337"
FT CONFLICT 320
FT /note="F -> L (in Ref. 1; AAD13780)"
FT /evidence="ECO:0000305"
FT CONFLICT 561
FT /note="A -> T (in Ref. 1; AAD13780)"
FT /evidence="ECO:0000305"
FT CONFLICT 630
FT /note="V -> I (in Ref. 1; AAD13780)"
FT /evidence="ECO:0000305"
FT CONFLICT 722
FT /note="E -> G (in Ref. 1; AAD13780)"
FT /evidence="ECO:0000305"
FT CONFLICT 772
FT /note="K -> E (in Ref. 1; AAD13780)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 980 AA; 109050 MW; F0CDC1104663FAD7 CRC64;
MAAATASSAL KRLDLRDPNA LFETHGAEEI RGLERQVRAE IEHKKEELRQ MVGERYRDLI
EAADTIGQMR RCAEGLVDAV QATDQYCARL RQAGSVAPRV PRAPQPQPPS EKFYSMAAQI
KLLLEIPEKI WSAMEASQHL QATQLYLLCC HLHSLLQLDS SNSRYSPILS RFPILIRQVA
AASHFRSTIL HESKMLLKCQ AVSDQAVAEA LCSIMLLEES SPRQALTDFL LARKATIQTL
LNQSHHGAGI KAQICSLVEL LATTLNQAHA LFYTLPEGVL PDPSLPCGLL FSTLETVTRQ
HPTGKGIGAL QGEMKLCSWF RHLPTSIIEF QPTLRTLAHP ISQEYLKDTL QKWIDMCNED
IKNGIGNLLM YVKSMKGLAG IRDAIWDLLS NESASHSWEV VCQRLLEKPL LFWEDLMQQL
FLDRLQTLTR EGFESISNSS KELLVSALQE LETNNSTSNK HVHFEQNMSF FLWSESPNDL
PSDAAWVSVA NRAQFASSGL SMKAQAISPC VQNFCSALDS KLKVKLDDLL AYLPSSDTPL
LKDTTPTHQP KNSAFDRYAD AGTVQDMLRT QSVACIKSVV GCIQAELCTI EEVTREQKDV
LHSTKLHAVL FMARLCQSLG ELCPHLKQCV VGQCGGSEKP AREARALKKQ GKGRAQDVLP
AQAQWQGVKE VLLQQSVMAY RVWSTALVKF LICGFTRSLL LRDAGSVLAT ATNWDELEIQ
EETESGSSVT SKIRLPTQPS WYVQSFLFSL CQEVNRVGGH ALPKVTLQEM LKTCMAQVIA
AYEQLTEENQ IKKEGAFPMT QNRALQLLYD LRYLTMVLSS KGEEVKSGRS KADSRMEKMT
ERLEALIDPF DLDVFTPHLN SNLNRLVQRT SVLFGLVTGT ENQFASRSST FNSQEPHNIL
PLASSQIRFG LLPLSMTSTR KARATSRSVE TQAQVGPPAL SRVGDPTTHP GSLFRQLASE
EDDSPAPSLF KLAWLSSMTK
