COG1_SCHPO
ID COG1_SCHPO Reviewed; 701 AA.
AC Q9UTL1;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=Conserved oligomeric Golgi complex subunit 1;
DE Short=COG complex subunit 1;
GN Name=cog1; ORFNames=SPAC144.15c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Acts as essential component of the peripheral membrane COG
CC complex that is involved in intra-Golgi protein trafficking. COG is
CC located at the cis-Golgi, and regulates tethering of retrograde intra-
CC Golgi vesicles and possibly a number of other membrane trafficking
CC events (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the conserved oligomeric Golgi (COG) complex
CC which consists of eight different proteins cog1-cog8. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC {ECO:0000269|PubMed:16823372}. Golgi apparatus membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}; Cytoplasmic side
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the COG1 family. {ECO:0000305}.
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DR EMBL; CU329670; CAB59695.1; -; Genomic_DNA.
DR PIR; T37682; T37682.
DR RefSeq; NP_594676.1; NM_001020105.2.
DR AlphaFoldDB; Q9UTL1; -.
DR SMR; Q9UTL1; -.
DR STRING; 4896.SPAC144.15c.1; -.
DR MaxQB; Q9UTL1; -.
DR PaxDb; Q9UTL1; -.
DR EnsemblFungi; SPAC144.15c.1; SPAC144.15c.1:pep; SPAC144.15c.
DR PomBase; SPAC144.15c; cog1.
DR VEuPathDB; FungiDB:SPAC144.15c; -.
DR HOGENOM; CLU_393378_0_0_1; -.
DR OMA; EVFRTHS; -.
DR PRO; PR:Q9UTL1; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017119; C:Golgi transport complex; ISO:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0000301; P:retrograde transport, vesicle recycling within Golgi; ISO:PomBase.
DR InterPro; IPR033370; COG1.
DR PANTHER; PTHR31658; PTHR31658; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Golgi apparatus; Membrane; Nucleus; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..701
FT /note="Conserved oligomeric Golgi complex subunit 1"
FT /id="PRO_0000304070"
SQ SEQUENCE 701 AA; 81561 MW; DC5BC3128195C97E CRC64;
MVETDLMSSH SSNWKEIFRT HSIAQTIQLE KFVSQQIEEK GRELQQNVCF NYQSFIEASE
NLSNIRNNLE KVLQNSYEFQ SMVSLPKVDR VSKFLSDNES ISQTSGDYFI FLQRFYAHAI
LFVMELFNKE QYLQSSKLLI FCLRILPADL PNDHQCHILV NRLESCKNYL NNRLKQAMTS
SLSKVSVVTS WILLNQANIS SGLDIFLQEC EDQLLILNDA REFSLTFLNT LKLARDFPNE
IRSYLEASKN FNIFKEKEIL RNICLDECYL KAYFSAEDVK VTTPFETLQQ FDGDNILQQW
KLSFFSKISH SEKSFFSNAT SLTTLYQILE GLLSELSEPQ FKEFYELWNS ILQNHFIISS
RNIIDSLGLY VNKIKEKLQI CFEIPPTNSF DPWSFQLKQQ VLNELKQNIL PACGMDDGFQ
RFWQSLASFD MVLDESLQVL KKLQTLHLSF TLGDIIPNYL TLADYLLNFV KTSFAQIYEL
VCSFVNNVAV MESSSEKQLR TSRCLKIVRL LKQFRHMDES VPFDDLIYKL QNILVRELTD
FTTGIYINES KINLDVAACI TGNFFGPSFA LYNSLIMLID KLEVLGFDIV SDKFKGLLTP
NLFESLFILN LERLKAAKSM DHMKQNTFDM EFINYLSDFT NNPREVIDYQ HFIELIDLHV
QDEFSKEDFD TVRANVKECV PKLLSFFTVL LPRVKAQKVI T
