COG2_ARATH
ID COG2_ARATH Reviewed; 756 AA.
AC F4JRR1; Q9ASS9; Q9SZX4;
DT 13-NOV-2019, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Conserved oligomeric Golgi complex subunit 2 {ECO:0000303|PubMed:27448097};
DE Short=COG complex subunit 2 {ECO:0000303|PubMed:27448097};
DE AltName: Full=Component of oligomeric Golgi complex 2 {ECO:0000303|PubMed:27448097};
GN Name=COG2 {ECO:0000303|PubMed:27448097};
GN OrderedLocusNames=At4g24840 {ECO:0000312|Araport:AT4G24840};
GN ORFNames=F6I7.50 {ECO:0000312|EMBL:CAB41124.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22223895; DOI=10.1074/mcp.m111.015131;
RA Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T.,
RA Giglione C.;
RT "Comparative large-scale characterisation of plant vs. mammal proteins
RT reveals similar and idiosyncratic N-alpha acetylation features.";
RL Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012).
RN [5]
RP FUNCTION, INTERACTION WITH FPP3/VETH1 AND FPP2/VETH2, AND SUBCELLULAR
RP LOCATION.
RX PubMed=25541219; DOI=10.1093/pcp/pcu197;
RA Oda Y., Iida Y., Nagashima Y., Sugiyama Y., Fukuda H.;
RT "Novel coiled-coil proteins regulate exocyst association with cortical
RT microtubules in xylem cells via the conserved oligomeric golgi-complex 2
RT protein.";
RL Plant Cell Physiol. 56:277-286(2015).
RN [6]
RP SUBUNIT, INTERACTION WITH COG3 AND COG4, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=27448097; DOI=10.1371/journal.pgen.1006140;
RA Tan X., Cao K., Liu F., Li Y., Li P., Gao C., Ding Y., Lan Z., Shi Z.,
RA Rui Q., Feng Y., Liu Y., Zhao Y., Wu C., Zhang Q., Li Y., Jiang L., Bao Y.;
RT "Arabidopsis COG complex subunits COG3 and COG8 modulate golgi morphology,
RT vesicle trafficking homeostasis and are essential for pollen tube growth.";
RL PLoS Genet. 12:E1006140-E1006140(2016).
RN [7]
RP INTERACTION WITH SEC15B.
RC STRAIN=cv. Columbia;
RX PubMed=27801942; DOI=10.1111/nph.14267;
RA Vukasinovic N., Oda Y., Pejchar P., Synek L., Pecenkova T., Rawat A.,
RA Sekeres J., Potocky M., Zarsky V.;
RT "Microtubule-dependent targeting of the exocyst complex is necessary for
RT xylem development in Arabidopsis.";
RL New Phytol. 213:1052-1067(2017).
CC -!- FUNCTION: Required for normal Golgi morphology and function (By
CC similarity). Ensures, when in complex with FPP3/VETH1 and FPP2/VETH2,
CC the correct secondary cell wall (SCW) deposition pattern by recruiting
CC exocyst components to cortical microtubules in xylem cells during
CC secondary cell wall deposition (PubMed:25541219). {ECO:0000250,
CC ECO:0000269|PubMed:25541219}.
CC -!- SUBUNIT: Homodimer (PubMed:27448097). Component of the conserved
CC oligomeric Golgi complex which is composed of eight different subunits
CC and is required for normal Golgi morphology and localization
CC (Probable). Binds to COG3 and COG4 (PubMed:27448097). Interacts with
CC FPP3/VETH1 and FPP2/VETH2; this interaction promotes the association
CC between cortical microtubules and EXO70A1 (PubMed:25541219). Binds to
CC SEC15B, and, possibly, with EXO70A1, SEC3A and SEC10A
CC (PubMed:27801942). {ECO:0000250, ECO:0000269|PubMed:25541219,
CC ECO:0000269|PubMed:27448097, ECO:0000269|PubMed:27801942,
CC ECO:0000305|PubMed:27448097}.
CC -!- INTERACTION:
CC F4JRR1; Q5ICL9: NPR4; NbExp=3; IntAct=EBI-4429018, EBI-1392093;
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:O59705}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:O59705}; Cytoplasmic side
CC {ECO:0000250|UniProtKB:O59705}. Note=Localized at vesicle-like small
CC compartments at cortical microtubules. {ECO:0000269|PubMed:25541219}.
CC -!- SIMILARITY: Belongs to the COG2 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB41124.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB79394.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL049657; CAB41124.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161562; CAB79394.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE84970.1; -; Genomic_DNA.
DR EMBL; AF367300; AAK32887.1; -; mRNA.
DR EMBL; AY091689; AAM10288.1; -; mRNA.
DR PIR; T06668; T06668.
DR RefSeq; NP_567710.1; NM_118617.5.
DR AlphaFoldDB; F4JRR1; -.
DR IntAct; F4JRR1; 38.
DR STRING; 3702.AT4G24840.1; -.
DR TCDB; 3.A.31.1.2; the endosomal sorting complexes required for transport iii (escrt-iii) family.
DR PaxDb; F4JRR1; -.
DR PRIDE; F4JRR1; -.
DR ProteomicsDB; 218394; -.
DR EnsemblPlants; AT4G24840.1; AT4G24840.1; AT4G24840.
DR GeneID; 828587; -.
DR Gramene; AT4G24840.1; AT4G24840.1; AT4G24840.
DR KEGG; ath:AT4G24840; -.
DR Araport; AT4G24840; -.
DR TAIR; locus:2126808; AT4G24840.
DR eggNOG; KOG2307; Eukaryota.
DR HOGENOM; CLU_005470_0_0_1; -.
DR InParanoid; F4JRR1; -.
DR OMA; CWAEGVY; -.
DR OrthoDB; 190117at2759; -.
DR PRO; PR:F4JRR1; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; F4JRR1; baseline and differential.
DR GO; GO:0031410; C:cytoplasmic vesicle; IDA:UniProtKB.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017119; C:Golgi transport complex; IBA:GO_Central.
DR GO; GO:0000325; C:plant-type vacuole; HDA:TAIR.
DR GO; GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
DR GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0060178; P:regulation of exocyst localization; IDA:UniProtKB.
DR InterPro; IPR009316; COG2.
DR InterPro; IPR024603; COG_complex_COG2_C.
DR InterPro; IPR024602; COG_su2_N.
DR PANTHER; PTHR12961; PTHR12961; 1.
DR Pfam; PF06148; COG2; 1.
DR Pfam; PF12022; DUF3510; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Golgi apparatus; Membrane; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..756
FT /note="Conserved oligomeric Golgi complex subunit 2"
FT /id="PRO_0000448525"
FT REGION 173..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 62..82
FT /evidence="ECO:0000255"
FT CONFLICT 682
FT /note="L -> F (in Ref. 3; AAK32887/AAM10288)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 756 AA; 84619 MW; 956A87FC4FDCAB8F CRC64;
MSDLVATSPS PSSAPRSATD FFSDPYDSHP LWFKPSLFLS PNFDSESYIS ELRTFVPFDT
LRSELRSHLA SLNRELVDLI NRDYADFVNL STKLVDIDAA VVRMRAPLLE LREKITGFRG
SVEAALFALR NGLQQRSDAA AAREVLELLL DTFHVVSKVE KLIKVLPSTP SDWQNEDANS
MGRSSMNDEN STQQDGTTMR ETQSMLLERI ASEMNRLKFY MAHAQNLPFI ENMEKRIQSA
SVLLDASLGH CFIDGLNNSD TSVLYNCLRA YAAIDNTNAA EEIFRTTIVA PFIQKIITHE
TTTNAAGTSE DELENDYKQI KHFIAKDCKM LLEISSTDKS GLHVFDFLAN SILKEVLWAI
QKVKPGAFSP GRPTEFLKNY KASLDFLAYL EGYCPSRSAV TKFRAEAICV EFMKQWNVGV
YFSLRFQEIA GALDSALTSP SLVFIQDSDK ESSLNLILRQ SDTLLECLRS CWKEDVLVFS
AADKFLRLTL QLLSRYSFWV SSALNNRKSN ASPSPGCEWA VSATAEDFVY VIHDVNCLVS
EVCGDYLGHI SQYLSSSSTE VLDVVRISIE QGGVSLEKVL PLLTKTIIDV IVDKSVEDLR
QLRGITATFR MTNKPLPVRH SPYVVGLLRP VKAFLEGDKA RNYLTQKTKE ELLHGSVSEI
TRRYYELAAD VVSVARKTQS SLQKLRQNAQ RRGGAASGVS DQNVSETDKM CMQLFLDIQE
YGRNVSALGL KPADIPEYCS FWQCVAPADR QNSISV
