ID   COG2_DICDI              Reviewed;         904 AA.
AC   Q54UC2;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Conserved oligomeric Golgi complex subunit 2;
DE            Short=COG complex subunit 2;
DE   AltName: Full=Component of oligomeric Golgi complex 2;
GN   Name=cog2; ORFNames=DDB_G0281163;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Required for normal Golgi function. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the conserved oligomeric Golgi complex which is
CC       composed of eight different subunits and is required for normal Golgi
CC       morphology and localization. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the COG2 family. {ECO:0000305}.
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DR   EMBL; AAFI02000040; EAL66878.1; -; Genomic_DNA.
DR   RefSeq; XP_640854.1; XM_635762.1.
DR   AlphaFoldDB; Q54UC2; -.
DR   STRING; 44689.DDB0237852; -.
DR   PaxDb; Q54UC2; -.
DR   EnsemblProtists; EAL66878; EAL66878; DDB_G0281163.
DR   GeneID; 8622910; -.
DR   KEGG; ddi:DDB_G0281163; -.
DR   dictyBase; DDB_G0281163; cog2.
DR   eggNOG; KOG2307; Eukaryota.
DR   HOGENOM; CLU_005470_1_0_1; -.
DR   InParanoid; Q54UC2; -.
DR   OMA; TFIDKCM; -.
DR   PhylomeDB; Q54UC2; -.
DR   Reactome; R-DDI-6807878; COPI-mediated anterograde transport.
DR   Reactome; R-DDI-6811438; Intra-Golgi traffic.
DR   PRO; PR:Q54UC2; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0017119; C:Golgi transport complex; IBA:GO_Central.
DR   GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR   GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR009316; COG2.
DR   InterPro; IPR024603; COG_complex_COG2_C.
DR   InterPro; IPR024602; COG_su2_N.
DR   PANTHER; PTHR12961; PTHR12961; 1.
DR   Pfam; PF06148; COG2; 1.
DR   Pfam; PF12022; DUF3510; 1.
PE   3: Inferred from homology;
KW   Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..904
FT                   /note="Conserved oligomeric Golgi complex subunit 2"
FT                   /id="PRO_0000341681"
FT   REGION          384..424
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          644..669
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   904 AA;  103901 MW;  E156630E7BCC1FB4 CRC64;
     MAMNLKNSSS GGNLTSSPSY NSFSSLNLSG NSFNNGSGSG SGSGSGSNEY IPLCFSKDVF
     TSNTFEVDQF ISDCRKRVNL ESVQKDLREY SKHLDSELIE LINKEYQSFF SLSTSLVGFD
     TILNEFSISQ SSIKSEIKSF NNEIVKVRGL VEDKLNEKKS IEQKKKLLQL YISISETLNN
     MNHLFDQLYQ LTHPNDFKKI NNNNNNHTNN ETNINDGDVL ELLIDRISNS FYQIQNQMSS
     LTNDELKFNI FQSLSLKIMD LSNKIEEKVE PIFKESLKRF INVNNNNKEI VDDNNEKQNK
     YDERILLVCL KTFQTIDKLN VPYKLFKTLI VKPRLAQIVS LRNLEINKST TDGLSQIYNS
     IIEFLKNQCS SFFDISNLIN NNLKEKQSNN NNNNNNNNNN NNNNNNNNQI NNNSNNNNNN
     INNNNINNNY NNNIILYNNY NFISQSVLPE IDESLGFFKQ IFATGIPDLF YKNYYLTFNF
     IQSIEVNFLT NKELLTQFRQ SSSYSSLWKK WNFAVYFQLC FTNIAQHFEF NYLRIPLFDQ
     LTLPTNNITN NNNNNNENNN EFYLKSTDGL RLSMDKCWSN SNFIFDLSSK FFKLFLQLIA
     RYDTFISDTL IPLELELQQQ LQQQQLQQQQ QQQQQQQNIG DSVIKITPKS PPSLSNQSPI
     SSSTTLNNKQ SSPENFIYII SDIYKIKSKI STNYKELIIK TIGNHQNQHE ILNLINDGIL
     ESCKTLEQLI PRISIIIENH LISKCLEPIE IISTLRSTYR MTNKPVPTKP SIYVSNLISP
     LEILINNKAS SLHFIPPEIK LNWAISVLTP VTESFKNAAT NLIQSVTQSN DIINKMVKKS
     KPTTTTSGGD MSDMDKISLQ LYLDVDKFGL YIQKFGINLL TFEPFLGLKS IVEPFKKLIL
     NQNK