COG2_DROME
ID COG2_DROME Reviewed; 710 AA.
AC Q9VF78; Q8SZC5; Q9XZ52;
DT 15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Conserved oligomeric Golgi complex subunit 2;
DE Short=COG complex subunit 2;
DE AltName: Full=Component of oligomeric Golgi complex 2 {ECO:0000312|FlyBase:FBgn0026634};
DE AltName: Full=LdlCp-related protein {ECO:0000312|FlyBase:FBgn0026634};
GN Name=Cog2 {ECO:0000312|FlyBase:FBgn0026634};
GN Synonyms=ldlCp {ECO:0000312|FlyBase:FBgn0026634};
GN ORFNames=CG6177 {ECO:0000312|FlyBase:FBgn0026634};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Fyrberg E.A., Fyrberg C.C.;
RT "Drosophila melanogaster gene for ldlCp-related protein.";
RL Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: Required for normal Golgi morphology and function.
CC {ECO:0000250}.
CC -!- SUBUNIT: Component of the conserved oligomeric Golgi complex which is
CC composed of eight different subunits and is required for normal Golgi
CC morphology and localization. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}; Cytoplasmic side
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the COG2 family. {ECO:0000305}.
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DR EMBL; AF132535; AAD31443.1; -; Genomic_DNA.
DR EMBL; AF132532; AAD31443.1; JOINED; Genomic_DNA.
DR EMBL; AF132533; AAD31443.1; JOINED; Genomic_DNA.
DR EMBL; AF132534; AAD31443.1; JOINED; Genomic_DNA.
DR EMBL; AE014297; AAF55182.1; -; Genomic_DNA.
DR EMBL; AY070962; AAL48584.1; -; mRNA.
DR RefSeq; NP_524366.1; NM_079642.3.
DR AlphaFoldDB; Q9VF78; -.
DR SMR; Q9VF78; -.
DR BioGRID; 66933; 1.
DR DIP; DIP-23947N; -.
DR STRING; 7227.FBpp0082568; -.
DR PaxDb; Q9VF78; -.
DR PRIDE; Q9VF78; -.
DR EnsemblMetazoa; FBtr0083114; FBpp0082568; FBgn0026634.
DR GeneID; 41870; -.
DR KEGG; dme:Dmel_CG6177; -.
DR CTD; 22796; -.
DR FlyBase; FBgn0026634; Cog2.
DR VEuPathDB; VectorBase:FBgn0026634; -.
DR eggNOG; KOG2307; Eukaryota.
DR GeneTree; ENSGT00390000012040; -.
DR HOGENOM; CLU_005470_1_0_1; -.
DR InParanoid; Q9VF78; -.
DR OMA; CWAEGVY; -.
DR OrthoDB; 190117at2759; -.
DR PhylomeDB; Q9VF78; -.
DR Reactome; R-DME-6807878; COPI-mediated anterograde transport.
DR Reactome; R-DME-6811438; Intra-Golgi traffic.
DR BioGRID-ORCS; 41870; 0 hits in 1 CRISPR screen.
DR ChiTaRS; ldlCp; fly.
DR GenomeRNAi; 41870; -.
DR PRO; PR:Q9VF78; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0026634; Expressed in oviduct (Drosophila) and 29 other tissues.
DR Genevisible; Q9VF78; DM.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017119; C:Golgi transport complex; IDA:FlyBase.
DR GO; GO:0033227; P:dsRNA transport; IMP:FlyBase.
DR GO; GO:0007030; P:Golgi organization; ISS:UniProtKB.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; ISS:UniProtKB.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR009316; COG2.
DR InterPro; IPR024603; COG_complex_COG2_C.
DR InterPro; IPR024602; COG_su2_N.
DR PANTHER; PTHR12961; PTHR12961; 1.
DR Pfam; PF06148; COG2; 1.
DR Pfam; PF12022; DUF3510; 1.
PE 2: Evidence at transcript level;
KW Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW Transport.
FT CHAIN 1..710
FT /note="Conserved oligomeric Golgi complex subunit 2"
FT /id="PRO_0000213498"
FT CONFLICT 50..53
FT /note="EQLR -> DDVL (in Ref. 1; AAD31443)"
FT /evidence="ECO:0000305"
FT CONFLICT 129..130
FT /note="QL -> HV (in Ref. 1; AAD31443)"
FT /evidence="ECO:0000305"
FT CONFLICT 184
FT /note="K -> R (in Ref. 4; AAL48584)"
FT /evidence="ECO:0000305"
FT CONFLICT 193
FT /note="D -> E (in Ref. 1; AAD31443)"
FT /evidence="ECO:0000305"
FT CONFLICT 291..292
FT /note="LL -> FV (in Ref. 1; AAD31443)"
FT /evidence="ECO:0000305"
FT CONFLICT 324..325
FT /note="NS -> EF (in Ref. 1; AAD31443)"
FT /evidence="ECO:0000305"
FT CONFLICT 401
FT /note="V -> E (in Ref. 1; AAD31443)"
FT /evidence="ECO:0000305"
FT CONFLICT 512
FT /note="C -> R (in Ref. 1; AAD31443)"
FT /evidence="ECO:0000305"
FT CONFLICT 548
FT /note="G -> A (in Ref. 1; AAD31443)"
FT /evidence="ECO:0000305"
FT CONFLICT 647..648
FT /note="AA -> PR (in Ref. 1; AAD31443)"
FT /evidence="ECO:0000305"
FT CONFLICT 698
FT /note="M -> V (in Ref. 4; AAL48584)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 710 AA; 81136 MW; E6B420B6244B214F CRC64;
MHDPVKKSAH LTAGSTSTAE KLCFDKNEFM KANFSVDEFL HKNRNAPSLE QLRDNLGLYL
KGLRAAMIDL INEDYADFVN LSANLVGLDQ NIKTIQQPLE QFRSDIESIH GLIDENVTEL
RAQLEEKRQL REFKRGLQSL KKVYETINKL QDLIDRKLSG EQPIKAVDLE RAALDLIQLK
FHEKHCFKHL SPDHQGKIQQ LEEQLHQHLR RFFNDALSQA RNSAPESLER CLRIYITLNA
CDQAECAFRE DVVAPYMTGV IGEQQLQNSP QGLAGIYSKI LNFISLHMTD LLRLTLYSDK
FPGFNFVVNS YWSDVETRLE LHMNSIFAPG NSEVFYVKYK CTRDFLGKIE ELLTCSGEQA
VTFYRQHKQT KSFEARWNLP VYFQICFQEI AGKFEAQLEP VLQEDSLKDN LTDSDYKISA
FNAAKEAMTR CWAEGVYLPE VFPKFYKLNV QVVLRLSRWI TDAITQSKGS NFSKPYTRNQ
LLIALHADIR KLDAHLPELQ QLIIKSVPVE QCTKIFSDVL AKSMSCLADT LGAHLTNIQK
TLVELLIGEC ETENVRQVND LPRLYRKTNR EVPTRCSSYV EQMLRPLKAF AQQNESQLGT
LVVEQILAEV ASHITKAYFN VVSDVLTSVQ KTEESLRRLR NVKSGGAATV STGSSAVMSD
DDKIRVQLRV DVTSWRQELC KLNFQATQID KLVELTNMVE DSIKLKDNSA
