COG2_MOUSE
ID COG2_MOUSE Reviewed; 731 AA.
AC Q921L5; Q3TF44; Q9CSQ1;
DT 11-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Conserved oligomeric Golgi complex subunit 2;
DE Short=COG complex subunit 2;
DE AltName: Full=Component of oligomeric Golgi complex 2;
DE AltName: Full=Low density lipoprotein receptor defect C-complementing protein;
GN Name=Cog2; Synonyms=Ldlc;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Required for normal Golgi morphology and function.
CC {ECO:0000250}.
CC -!- SUBUNIT: Component of the conserved oligomeric Golgi complex which is
CC composed of eight different subunits and is required for normal Golgi
CC morphology and localization. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}; Cytoplasmic side
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the COG2 family. {ECO:0000305}.
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DR EMBL; BC011435; AAH11435.1; -; mRNA.
DR EMBL; AK012236; BAB28112.1; -; mRNA.
DR EMBL; AK169298; BAE41054.1; -; mRNA.
DR CCDS; CCDS22771.1; -.
DR RefSeq; NP_084022.2; NM_029746.3.
DR AlphaFoldDB; Q921L5; -.
DR SMR; Q921L5; -.
DR BioGRID; 218073; 4.
DR IntAct; Q921L5; 2.
DR STRING; 10090.ENSMUSP00000034460; -.
DR iPTMnet; Q921L5; -.
DR PhosphoSitePlus; Q921L5; -.
DR EPD; Q921L5; -.
DR MaxQB; Q921L5; -.
DR PaxDb; Q921L5; -.
DR PeptideAtlas; Q921L5; -.
DR PRIDE; Q921L5; -.
DR ProteomicsDB; 283601; -.
DR Antibodypedia; 34680; 211 antibodies from 26 providers.
DR DNASU; 76332; -.
DR Ensembl; ENSMUST00000034460; ENSMUSP00000034460; ENSMUSG00000031979.
DR GeneID; 76332; -.
DR KEGG; mmu:76332; -.
DR UCSC; uc009nxd.2; mouse.
DR CTD; 22796; -.
DR MGI; MGI:1923582; Cog2.
DR VEuPathDB; HostDB:ENSMUSG00000031979; -.
DR eggNOG; KOG2307; Eukaryota.
DR GeneTree; ENSGT00390000012040; -.
DR HOGENOM; CLU_005470_0_0_1; -.
DR InParanoid; Q921L5; -.
DR OMA; CWAEGVY; -.
DR OrthoDB; 190117at2759; -.
DR PhylomeDB; Q921L5; -.
DR TreeFam; TF105824; -.
DR Reactome; R-MMU-6807878; COPI-mediated anterograde transport.
DR Reactome; R-MMU-6811438; Intra-Golgi traffic.
DR Reactome; R-MMU-6811440; Retrograde transport at the Trans-Golgi-Network.
DR BioGRID-ORCS; 76332; 14 hits in 74 CRISPR screens.
DR ChiTaRS; Cog2; mouse.
DR PRO; PR:Q921L5; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q921L5; protein.
DR Bgee; ENSMUSG00000031979; Expressed in embryonic brain and 182 other tissues.
DR ExpressionAtlas; Q921L5; baseline and differential.
DR Genevisible; Q921L5; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005795; C:Golgi stack; ISO:MGI.
DR GO; GO:0017119; C:Golgi transport complex; ISO:MGI.
DR GO; GO:0044877; F:protein-containing complex binding; ISO:MGI.
DR GO; GO:0070085; P:glycosylation; ISO:MGI.
DR GO; GO:0007030; P:Golgi organization; ISO:MGI.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; ISO:MGI.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0000301; P:retrograde transport, vesicle recycling within Golgi; ISO:MGI.
DR InterPro; IPR009316; COG2.
DR InterPro; IPR024603; COG_complex_COG2_C.
DR InterPro; IPR024602; COG_su2_N.
DR PANTHER; PTHR12961; PTHR12961; 1.
DR Pfam; PF06148; COG2; 1.
DR Pfam; PF12022; DUF3510; 1.
PE 1: Evidence at protein level;
KW Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW Transport.
FT CHAIN 1..731
FT /note="Conserved oligomeric Golgi complex subunit 2"
FT /id="PRO_0000213496"
FT REGION 469..496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 659..680
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 271
FT /note="S -> G (in Ref. 1; AAH11435)"
FT /evidence="ECO:0000305"
FT CONFLICT 515
FT /note="L -> M (in Ref. 1; AAH11435)"
FT /evidence="ECO:0000305"
FT CONFLICT 719
FT /note="V -> I (in Ref. 1; AAH11435)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 731 AA; 82040 MW; 294F5594C48CA960 CRC64;
MEKRRMNLPT GPDTLCFDKD EFMKEDFDVD HFVSDCRKRV QLEELRDDLE LYYKLLKTAM
VELINKDYAD FVNLSTNLVG MDRALNQLSV PLGQLREEVL SLRSSVSEGI LAVDERMSKQ
EDIRKKKMSV LRLIQVIRSV EKIEKILNSQ SSKDVSSQEA SSPLLTGQVL ERIATEFNQL
QFHAVQSKGM PLLDKVRPRI AGITAMLQQS LEGLLLEGLQ TSDVDIVRHC LRTYATIDKT
QDAEALVGQV LVKPYVNEVI VEQFVESHPS SLQLMYNKLL EFVPHHCRLL REVTGGAVSS
EKGTIVPGYD FLVNSVWPEI VRGLEEKLPS LFNPGDPDAF HQKYTVSMDF VQRFERQCGS
QASVKRLRAH PAYHNFSNKW NLPVYFQIRF REVAGSLEAA LTDGLEDAPA GSPYCLLASH
RTWISLGKCW SDEMFLPLLA HRLWRLTLQI LARFSVFVSE LSVRPVSNES AKETKKPLTG
SKDPSEDQGS HASEASAASI SSTQLVYVVS DLGRLQEWLP DLLETVKQKL EMIGFKNFSS
ISAALEDSQS ALSAHVPALS SRIVQDLSES CFSYLKSALE VPRLYRRTNK EVPSTASSYV
DSALKPLYQL QSGHGDKVQP AVMQSWLQEA LSDSTHRYFE TVSDVLNSVK KMEESLKRLK
QARRSPATNP VSSSGGGMSD DDKIRLQLAL DVEHLGEQIQ RMGLQTSDIK SFPALMELVL
AARDQAAAEQ P
