ID   COG3_AEDAE              Reviewed;         899 AA.
AC   Q16ZN9;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Conserved oligomeric Golgi complex subunit 3;
DE            Short=COG complex subunit 3;
DE   AltName: Full=Component of oligomeric Golgi complex 3;
GN   Name=Cog3 {ECO:0000250|UniProtKB:Q961G1}; ORFNames=AAEL008135;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1] {ECO:0000312|EMBL:EAT40119.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- FUNCTION: Involved in ER-Golgi transport.
CC       {ECO:0000250|UniProtKB:Q96JB2}.
CC   -!- SUBUNIT: Component of the conserved oligomeric Golgi complex which is
CC       composed of eight different subunits and is required for normal Golgi
CC       morphology and localization. {ECO:0000250|UniProtKB:Q14746}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}; Cytoplasmic side
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the COG3 family. {ECO:0000255}.
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DR   EMBL; CH477487; EAT40119.1; -; Genomic_DNA.
DR   RefSeq; XP_001658958.1; XM_001658908.1.
DR   AlphaFoldDB; Q16ZN9; -.
DR   SMR; Q16ZN9; -.
DR   STRING; 7159.AAEL008135-PA; -.
DR   PRIDE; Q16ZN9; -.
DR   GeneID; 5570156; -.
DR   KEGG; aag:5570156; -.
DR   VEuPathDB; VectorBase:AAEL008135; -.
DR   eggNOG; KOG2604; Eukaryota.
DR   HOGENOM; CLU_011639_1_1_1; -.
DR   InParanoid; Q16ZN9; -.
DR   OMA; LDEFELW; -.
DR   OrthoDB; 692986at2759; -.
DR   PhylomeDB; Q16ZN9; -.
DR   Proteomes; UP000008820; Unassembled WGS sequence.
DR   GO; GO:0005801; C:cis-Golgi network; IEA:InterPro.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0017119; C:Golgi transport complex; ISS:UniProtKB.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; ISS:UniProtKB.
DR   GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; ISS:UniProtKB.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   InterPro; IPR007265; COG_su3.
DR   PANTHER; PTHR13302; PTHR13302; 1.
DR   Pfam; PF04136; Sec34; 1.
PE   3: Inferred from homology;
KW   Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..899
FT                   /note="Conserved oligomeric Golgi complex subunit 3"
FT                   /id="PRO_0000306270"
SQ   SEQUENCE   899 AA;  100759 MW;  D0A3BCF5DAC1AC0A CRC64;
     MDDVATMKSE NANLRKIQSR LLQWEQKDNP LAPLSSAQNE FINRLADSLT GATSPGANPL
     MESQELSLEC KTTLVDFKNS GSVIDSTQDF LSWYNSIDSE ILEHYDDVYL DYYGQLKQRS
     VECDKLLEEI DVSLESLQKL TNEYKFVSEK TSSLHQASEN LLQDQTKLNE IGEEIRRRLK
     YFSQAESIYQ RLQNPTFSVS NDTFVEILNT IDECLEYMRV NPGFSEAFAY GVKYRNCLSK
     ATQMMRNYVS NILTNATAQI LGPQRSETGM EQGSEAAFAL YYGKFQASAP RVKRITGMIE
     GRLDRSVEYE QLLAALHQQF LANRATIMSS GVEQAIRDLS KKHKGDHCAL VRSACAFMVH
     VCQDEHRLFF QFFTNSSPQL TAYMEGLCTI LYDTLRPFII RIDHLETLAE ICSILRVEML
     DEHVTYNPES LEAFAKIVYQ LLQDVQERIG FRAQNYLESD ILNYRPSAGD LAYPEKLEMM
     ESIALSLQEN YLRRADSRSS IVSMTSLASQ EVESINQQAE QASKSRASNS PADLHGMWYP
     TVRRTLVCLS RLYRCIDRAI FQSLSQQALA YCIQSVSNAA AQISQKKTSI DGELFEIKHL
     LILREQIAPF RVDFTVKETS LDFSKVKTAA FELLQKRKQL FALGSNNALL EFLLDGTPQV
     KEQLLDSRKD VDRQLKMVCE MFIKDATRQL VGPILNFIDT AQNHVKQSAA SGSSQPGAKQ
     QQQQGLALRM AAFAAPQQIS SIIQESIRNI KTKLGALQRS MQLYLANKDT EFILFRPIRN
     NIIGSFVKLE QLLTTNSYSK DDLTVVSCPS AEQISVLLSS VNLSGTVGAE PFGGIQRKIS
     ASSMGGNGGA SVKPPIEKKV SFDSGANTVV QIEAGSEAVE VSAEEASVEE ALEGKIEAE