ID   COG3_ARATH              Reviewed;         784 AA.
AC   F4HQ84; Q8L744; Q9FX37;
DT   13-NOV-2019, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Conserved oligomeric Golgi complex subunit 3 {ECO:0000303|PubMed:27448097};
DE            Short=COG complex subunit 3 {ECO:0000303|PubMed:27448097};
DE   AltName: Full=Component of oligomeric Golgi complex 3 {ECO:0000303|PubMed:27448097};
GN   Name=COG3 {ECO:0000303|PubMed:27448097};
GN   OrderedLocusNames=At1g73430 {ECO:0000312|Araport:AT1G73430};
GN   ORFNames=T9L24.37 {ECO:0000312|EMBL:AAG30981.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   FUNCTION, DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION, INTERACTION WITH
RP   COG1; COG2; COG4; COG5 AND COG8, SUBUNIT, GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=27448097; DOI=10.1371/journal.pgen.1006140;
RA   Tan X., Cao K., Liu F., Li Y., Li P., Gao C., Ding Y., Lan Z., Shi Z.,
RA   Rui Q., Feng Y., Liu Y., Zhao Y., Wu C., Zhang Q., Li Y., Jiang L., Bao Y.;
RT   "Arabidopsis COG complex subunits COG3 and COG8 modulate golgi morphology,
RT   vesicle trafficking homeostasis and are essential for pollen tube growth.";
RL   PLoS Genet. 12:E1006140-E1006140(2016).
CC   -!- FUNCTION: Acts as component of the peripheral membrane COG complex that
CC       is involved in intra-Golgi protein trafficking (PubMed:27448097).
CC       Involved in pollen tube growth by modulating Golgi morphology and
CC       vesicle trafficking homeostasis leading to the deposition of cell wall
CC       components and proteins at the pollen tube tip (PubMed:27448097).
CC       Required for sporophytic development (PubMed:27448097).
CC       {ECO:0000269|PubMed:27448097}.
CC   -!- SUBUNIT: Homodimer (PubMed:27448097). Component of the conserved
CC       oligomeric Golgi complex which is composed of eight different subunits
CC       and is required for normal Golgi morphology and localization
CC       (Probable). Interacts with COG1, COG2, COG4, COG5 and COG8
CC       (PubMed:27448097). {ECO:0000269|PubMed:27448097,
CC       ECO:0000305|PubMed:27448097}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC       {ECO:0000269|PubMed:27448097}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:P40094}; Cytoplasmic side
CC       {ECO:0000250|UniProtKB:P40094}.
CC   -!- DISRUPTION PHENOTYPE: Male-specific transmission defect due to
CC       incorrect deposition of cell wall components and proteins during pollen
CC       tube elongation, thus leading to disrupted pollen tube growth
CC       (PubMed:27448097). Embryo- and seedling-lethal associated with white
CC       seeds in siliques, delayed embryo development from the early stages,
CC       arrested at heart stages and resulting in abnormal curled cotyledons
CC       (PubMed:27448097). Altered Golgi bodies morphology (PubMed:27448097).
CC       Impaired Gamma-COP and TMN1/EMP12 tight association with the Golgi
CC       (PubMed:27448097). {ECO:0000269|PubMed:27448097}.
CC   -!- SIMILARITY: Belongs to the COG3 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAG30981.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC012396; AAG30981.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE35459.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE35460.1; -; Genomic_DNA.
DR   EMBL; AY139767; AAM98086.1; -; mRNA.
DR   PIR; H96760; H96760.
DR   RefSeq; NP_001117595.1; NM_001124123.2.
DR   RefSeq; NP_177485.2; NM_106002.4.
DR   AlphaFoldDB; F4HQ84; -.
DR   SMR; F4HQ84; -.
DR   STRING; 3702.AT1G73430.1; -.
DR   iPTMnet; F4HQ84; -.
DR   PaxDb; F4HQ84; -.
DR   PRIDE; F4HQ84; -.
DR   ProteomicsDB; 191402; -.
DR   EnsemblPlants; AT1G73430.1; AT1G73430.1; AT1G73430.
DR   EnsemblPlants; AT1G73430.2; AT1G73430.2; AT1G73430.
DR   GeneID; 843677; -.
DR   Gramene; AT1G73430.1; AT1G73430.1; AT1G73430.
DR   Gramene; AT1G73430.2; AT1G73430.2; AT1G73430.
DR   KEGG; ath:AT1G73430; -.
DR   Araport; AT1G73430; -.
DR   TAIR; locus:2206890; AT1G73430.
DR   eggNOG; KOG2604; Eukaryota.
DR   HOGENOM; CLU_011639_1_1_1; -.
DR   InParanoid; F4HQ84; -.
DR   OMA; LDEFELW; -.
DR   OrthoDB; 692986at2759; -.
DR   PRO; PR:F4HQ84; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; F4HQ84; baseline and differential.
DR   GO; GO:0005801; C:cis-Golgi network; IEA:InterPro.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0017119; C:Golgi transport complex; IPI:TAIR.
DR   GO; GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
DR   GO; GO:0007030; P:Golgi organization; IMP:TAIR.
DR   GO; GO:0048193; P:Golgi vesicle transport; IMP:TAIR.
DR   GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IBA:GO_Central.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:0009860; P:pollen tube growth; IMP:TAIR.
DR   InterPro; IPR007265; COG_su3.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   PANTHER; PTHR13302; PTHR13302; 1.
DR   Pfam; PF04136; Sec34; 1.
DR   SUPFAM; SSF74788; SSF74788; 1.
PE   1: Evidence at protein level;
KW   Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..784
FT                   /note="Conserved oligomeric Golgi complex subunit 3"
FT                   /id="PRO_0000448526"
FT   REGION          475..495
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        241
FT                   /note="L -> P (in Ref. 3; AAM98086)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   784 AA;  88609 MW;  1CBF45FE594EBEA0 CRC64;
     MATKAASSSS LPKSGAISKG YNFASTWEQS APLTEQQQAA IVSLSHAVAE RPFPANLVHE
     HVHRPENGLS VSVEDTHLGD SGAIEAVLVN TNQFYKWFTD LESAMKSETE EKYRHYVSTL
     TERIQTCDNI LHQVDETLDL FNELQLQHQG VTTKTKTLHD ACDRLLMEKQ KLMEFAEALR
     SKLNYFDELE NVSSNFYSPN MNVSNSNFLP LLKRLDECIS YIEDNPQYAE SSVYLLKFRQ
     LQSRALGMIR TYILAVLKTA ASQVQAAFRG TGGNKTSVSE GVEASVIYVR FKAAANELKP
     VLEEIESRSA RKEYVQILAE CHRLYCEQRL SLVKGIVHQR VSDFAKKEAL PSLTRSGCAY
     LMQVCHMEHQ LFTHFFPASS EEVSSLAPLV DPLSTYLYDI LRPKLIHEAN IDLLCELVHI
     LKVEVLGDQS ARQSEPLAGL RPTLQRILAD VNERLTFRAR TYIRDEIANY TPSDEDLDYP
     AKLEGSPNTT SETDLRDDEN ADVFKTWYPP LEKTLSCLSK LYRCLEQAVF TGLAQEAVEV
     CSLSIQKASK LIIKRSTTMD GQLFLIKHLL ILREQIAPFD IEFSVTHKEL DFSHLLEHLR
     RILRGQASLF DWSRSTSLAR TLSPRVLESQ IDAKKELEKC LKTTCEEFIM SVTKLVVDPM
     LSFVTKVTAI KVALSSGTQN HKVDSVMAKP LKEQAFATPD KVVELVQKVY AAIQQELLPI
     LAKMKLYLQN PSTRTILFKP IKTNIVEAHT QVESLLKAEY SAEEQANINM ISIQDLQTQL
     DNFL