COG3_DROME
ID COG3_DROME Reviewed; 905 AA.
AC Q961G1; Q9VQQ8;
DT 15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Conserved oligomeric Golgi complex subunit 3;
DE Short=COG complex subunit 3;
DE AltName: Full=Component of oligomeric Golgi complex 3;
GN Name=Cog3; ORFNames=CG3248;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-841; SER-845; SER-856;
RP SER-859 AND SER-862, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- FUNCTION: Involved in ER-Golgi transport. {ECO:0000250}.
CC -!- SUBUNIT: Component of the conserved oligomeric Golgi complex which is
CC composed of eight different subunits and is required for normal Golgi
CC morphology and localization. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}; Cytoplasmic side
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the COG3 family. {ECO:0000305}.
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DR EMBL; AE014134; AAF51107.2; -; Genomic_DNA.
DR EMBL; AY051613; AAK93037.1; -; mRNA.
DR RefSeq; NP_608779.1; NM_134935.3.
DR AlphaFoldDB; Q961G1; -.
DR SMR; Q961G1; -.
DR BioGRID; 59773; 4.
DR DIP; DIP-23437N; -.
DR IntAct; Q961G1; 1.
DR STRING; 7227.FBpp0077262; -.
DR iPTMnet; Q961G1; -.
DR PaxDb; Q961G1; -.
DR PRIDE; Q961G1; -.
DR EnsemblMetazoa; FBtr0077573; FBpp0077262; FBgn0031536.
DR GeneID; 33562; -.
DR KEGG; dme:Dmel_CG3248; -.
DR UCSC; CG3248-RA; d. melanogaster.
DR CTD; 83548; -.
DR FlyBase; FBgn0031536; Cog3.
DR VEuPathDB; VectorBase:FBgn0031536; -.
DR eggNOG; KOG2604; Eukaryota.
DR GeneTree; ENSGT00390000015682; -.
DR HOGENOM; CLU_011639_1_1_1; -.
DR InParanoid; Q961G1; -.
DR OMA; LDEFELW; -.
DR OrthoDB; 692986at2759; -.
DR PhylomeDB; Q961G1; -.
DR Reactome; R-DME-6807878; COPI-mediated anterograde transport.
DR Reactome; R-DME-6811438; Intra-Golgi traffic.
DR BioGRID-ORCS; 33562; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 33562; -.
DR PRO; PR:Q961G1; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0031536; Expressed in capitellum (Drosophila) and 26 other tissues.
DR Genevisible; Q961G1; DM.
DR GO; GO:0005801; C:cis-Golgi network; IEA:InterPro.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017119; C:Golgi transport complex; IDA:FlyBase.
DR GO; GO:0033227; P:dsRNA transport; IMP:FlyBase.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; ISS:UniProtKB.
DR GO; GO:0007030; P:Golgi organization; ISS:FlyBase.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; ISS:UniProtKB.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0007112; P:male meiosis cytokinesis; IMP:FlyBase.
DR InterPro; IPR007265; COG_su3.
DR PANTHER; PTHR13302; PTHR13302; 1.
DR Pfam; PF04136; Sec34; 1.
PE 1: Evidence at protein level;
KW Golgi apparatus; Membrane; Phosphoprotein; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..905
FT /note="Conserved oligomeric Golgi complex subunit 3"
FT /id="PRO_0000213502"
FT REGION 49..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 884..905
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..78
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 841
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 845
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 856
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 859
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 862
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
SQ SEQUENCE 905 AA; 101240 MW; AAD633D3003590E1 CRC64;
MDDVERIQSE NENLRKIRNR LMQWESKTDP LAALSIQQEE HLDVLTNLWR DSGPSAPAPT
TPTQVGPTDS SAAATSQSGD DIRLPAEGLQ NTNEFLLWFA DVSAEIEQRG DADYHKYLQQ
LEQRKAECSH MLDQIAGAME RLGALCDEYD FVSQKTSALN TASEQLIEEQ ERLQELSHEI
QRRLHYFSQV ELLNQRLQSP TLSVASEAFR ECLNKIDECL NYIEENPKFK DAAAYNVKYR
QCLAKASGLV RNYVTSVINQ ATEATLHPKN NMPDASAALK APDAAFALYY GKYQTAAAKV
KRVAQLIESR SEHSLDYAQL MADLQQHYLA QRASVMSPAV NLSIQNVKVA HKGDHCSLTR
SACAFLVHVC QDEQRLFYQF FSTGAPHLTV YLEGLCTILY DTMRPFIIHI NHLETLAEIC
SILRIEMLEE HVQQNPVALE AFATIAHQLL QDVQERLVFR AHLYLQSDIQ NFNPSSGDLA
YPEKLEMMES IALSLQEPAP LRRSDSRNSM VSSVSSAVET ESVATAYTVK QMNSPADLHG
MWYPTVRRTL VCLSRLYRCV DRPIFQGLSQ EALKLCIQSV SHAAGKISAN KTPIDGELFE
IKHLLILREQ IAPFRVDFTV KETSLDFSKV KTAAFGLLQK RKQLFSMGSN NALLEFLLEG
TPQIKEHLLD SRKEVDRQLK SVCEKYIKDA VQMLVGPLIT FLEKAQSLLA QSTPATPQSP
ESTKASYVLR QSPWASPQQI SSIIQETQRL IKAKLAVLQR SMQLYLSNRD TEFIIFRPIR
NNIIQSFVKL EQLLTTNGYS TDDMIITSCP SAEQVSILLS SASILAAEGV ASFAAAARKI
STSSSVEGST VGRKLSAMSN KSELVEEPKV EEVAGQIEVV PAEVQPPAKI EEEEVTETQT
QANSE
