ID   COG3_DROPS              Reviewed;         914 AA.
AC   Q29N70;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Conserved oligomeric Golgi complex subunit 3;
DE            Short=COG complex subunit 3;
DE   AltName: Full=Component of oligomeric Golgi complex 3;
GN   Name=Cog3 {ECO:0000250|UniProtKB:Q961G1}; ORFNames=GA16936;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1] {ECO:0000312|EMBL:EAL33473.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: Involved in ER-Golgi transport.
CC       {ECO:0000250|UniProtKB:Q96JB2}.
CC   -!- SUBUNIT: Component of the conserved oligomeric Golgi complex which is
CC       composed of eight different subunits and is required for normal Golgi
CC       morphology and localization. {ECO:0000250|UniProtKB:Q14746}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}; Cytoplasmic side
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the COG3 family. {ECO:0000255}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAL33473.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CH379060; EAL33473.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001356409.1; XM_001356373.3.
DR   AlphaFoldDB; Q29N70; -.
DR   SMR; Q29N70; -.
DR   STRING; 7237.FBpp0280216; -.
DR   EnsemblMetazoa; FBtr0281778; FBpp0280216; FBgn0076950.
DR   GeneID; 4817142; -.
DR   KEGG; dpo:Dpse_GA16936; -.
DR   eggNOG; KOG2604; Eukaryota.
DR   HOGENOM; CLU_011639_1_1_1; -.
DR   InParanoid; Q29N70; -.
DR   OMA; LDEFELW; -.
DR   PhylomeDB; Q29N70; -.
DR   Proteomes; UP000001819; Chromosome 4.
DR   Bgee; FBgn0076950; Expressed in female reproductive system and 2 other tissues.
DR   GO; GO:0005801; C:cis-Golgi network; IEA:InterPro.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0017119; C:Golgi transport complex; ISS:UniProtKB.
DR   GO; GO:0033227; P:dsRNA transport; IEA:EnsemblMetazoa.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; ISS:UniProtKB.
DR   GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; ISS:UniProtKB.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:0007112; P:male meiosis cytokinesis; IEA:EnsemblMetazoa.
DR   InterPro; IPR007265; COG_su3.
DR   PANTHER; PTHR13302; PTHR13302; 1.
DR   Pfam; PF04136; Sec34; 1.
PE   3: Inferred from homology;
KW   Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..914
FT                   /note="Conserved oligomeric Golgi complex subunit 3"
FT                   /id="PRO_0000306271"
FT   REGION          53..84
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          874..914
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        54..79
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        900..914
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   914 AA;  101832 MW;  DB0FEC0F5B834F75 CRC64;
     MDDVATAQSE NENLRKIRNR LMQWESKTDP LAALSVQQEE HLDVFANLWR DSGPTLPVGT
     TPTTAEPSDE ANTEGAPTKS TDDIELPAEG LQNTNDFLLW FVDVNAEIEQ RGDAVYHKYL
     QQLEQRKAEC SHMLGQISVA MDRLGALSDE YEFVSQKTSA LNTASEQLID EQEKLQDLSN
     EIQRRLHYFS QVELLNQRLQ SPTLSVASEA FRECLNKIDE CLNYIEENPK FKDAATYNVK
     YRQCLAKASG LVRNYVTSVI NQATEATLHP KNSATDSSSA LQAPDAAFAL YYGKYQTAAA
     KVKRVVQLIE TRLEHSNDYT QLMTDLQQHY LAQRASVMSP AVNLSIQNVK TAHKGDHCSL
     TRSACGFLVH VCQDEQRLFY QFFSTGAPHL TVYLEGLCTI LYDTLRPFII HINHLETLAE
     ICSILRIEML EEHVQQNPSA LEAFATIAHQ LLQDVQERLV FRAHLYLQSD IQNFNPSSGD
     LAYPEKLEMM ESIALSLQEP TPLRRSDSRA SVISSVSSVL ETESVDNSYR IKQMNSPADL
     HGMWYPTVRR TLVCLSRLYR CVDRPIFQGL SQEALKLCIQ SVSYAGGKIG AAKTPIDGEL
     FEIKHLLILR EQIAPFRVDF TVKETSLDFS KVKTAAFGLL QKRKQLFSMG SNNALLEFLL
     EGTPQIKEHL LDSRKEVDRQ LKTVCEKYIR DAVNMLIGPL ITFLDKTQSL LAQAASTTAS
     TPESSSPKAS YVLRQSPWAS PQQISSIIQE TQRMIKAKLA VLQRAMQLYL SNRDTEFIIF
     RPIRNNIIQS FVKLEQLLTT NGYSTDDMII TSCPSAEQVS ILLSSASILA AEGVASFAAA
     AARKISTSSS IEGAAAGGRK LSTMSNKAEL LRESKAEELE AVRSEAAPAP AESTPSENVV
     AELEVPTSAQ ASSE