COG3_SCHPO
ID COG3_SCHPO Reviewed; 735 AA.
AC Q9Y7Z4;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Conserved oligomeric Golgi complex subunit 3;
DE Short=COG complex subunit 3;
DE AltName: Full=Component of oligomeric Golgi complex 3;
GN Name=cog3; ORFNames=SPBC1539.05;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Acts as component of the peripheral membrane COG complex that
CC is involved in intra-Golgi protein trafficking. COG is located at the
CC cis- Golgi, and regulates tethering of retrograde intra-Golgi vesicles
CC and possibly a number of other membrane trafficking events (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the conserved oligomeric Golgi (COG or
CC Sec34/Sec35) complex which consists of eight different proteins cog1-
CC cog8. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}; Cytoplasmic side
CC {ECO:0000250}. Note=Localizes at the barrier septum.
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the COG3 family. {ECO:0000305}.
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DR EMBL; CU329671; CAB51337.1; -; Genomic_DNA.
DR PIR; T39464; T39464.
DR RefSeq; NP_596819.1; NM_001023839.2.
DR AlphaFoldDB; Q9Y7Z4; -.
DR SMR; Q9Y7Z4; -.
DR BioGRID; 276310; 1.
DR STRING; 4896.SPBC1539.05.1; -.
DR iPTMnet; Q9Y7Z4; -.
DR MaxQB; Q9Y7Z4; -.
DR PaxDb; Q9Y7Z4; -.
DR PRIDE; Q9Y7Z4; -.
DR EnsemblFungi; SPBC1539.05.1; SPBC1539.05.1:pep; SPBC1539.05.
DR GeneID; 2539758; -.
DR KEGG; spo:SPBC1539.05; -.
DR PomBase; SPBC1539.05; cog3.
DR VEuPathDB; FungiDB:SPBC1539.05; -.
DR eggNOG; KOG2604; Eukaryota.
DR HOGENOM; CLU_011639_0_0_1; -.
DR InParanoid; Q9Y7Z4; -.
DR OMA; LDEFELW; -.
DR PhylomeDB; Q9Y7Z4; -.
DR PRO; PR:Q9Y7Z4; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0032153; C:cell division site; HDA:PomBase.
DR GO; GO:0005801; C:cis-Golgi network; IEA:InterPro.
DR GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017119; C:Golgi transport complex; ISO:PomBase.
DR GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; ISO:PomBase.
DR GO; GO:0006886; P:intracellular protein transport; ISS:PomBase.
DR InterPro; IPR007265; COG_su3.
DR PANTHER; PTHR13302; PTHR13302; 1.
DR Pfam; PF04136; Sec34; 1.
PE 3: Inferred from homology;
KW Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW Transport.
FT CHAIN 1..735
FT /note="Conserved oligomeric Golgi complex subunit 3"
FT /id="PRO_0000316217"
SQ SEQUENCE 735 AA; 85999 MW; 561678F9CD39D21F CRC64;
MFDQLEFYPA VNYEDNETQN DIKLPEVAKL ENIETVHSIS KERRDSLTEI LNDSSSLPAR
PFSLPNPNNS TVEKQSLFPF EEKMNPIWII SRPTFSIEQD AEKKINELQT FTNIIDQILG
QTNNIESTLL SMKEKFESSE KKLSEFSEMC ENLSTDEMRF SEIADGIRKG LTIFAPLKEL
TRVFRHPPPD FAGKVSFKEH ITQLNTCIMF LEENLDFQES PHYLGQYKKL LSQAMDIFKP
YFIRIIKQTT DQVLKDSKKM DVHKQLHSSL FYARFSAVGH NLCPTITELC KLCSKESLDA
FLPAFYDVYF QCRTRLLKPV LDYHLKSFFM EKSISSYIQK SLALLQLTFF DENKLFREIL
IMDDFRFMHY WNNLCQSFFE NSRSLILHEK NLTELCEVCS YIQSFQNAIL EGEREDVDKK
VVEFLNPLVL ELQERLLFVV QTAIETDIQR YSPTEEDLNP IADDKSLLFD LEKLRLNNDE
EKLDPDVPQK LAMAQGWYPV VQKSLIILSK IYRLVNSQVF DEIALELVHS CIRSLVDAYR
YFSRNNDKQL ARLFLIKNFL VLKDQLNSFD IHYACIEAGV DLRKVWDSVR EWRSNLRGVL
QLVYETFPKF ITNAVDTRQE LNQQLRVAVN GYIETAVIHY TECLSIGNLE SITEFQNRIQ
KFPELRQQIS LYLSETWIIE LFLQAIREEV VSKFQNFYES IVANEDITGS DHNKSGTTSL
KHLNEYVEDI YSVMS
