COG4_ARATH
ID COG4_ARATH Reviewed; 738 AA.
AC Q8L838; O81330; Q9M133;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Conserved oligomeric Golgi complex subunit 4 {ECO:0000303|PubMed:27448097};
DE Short=COG complex subunit 4 {ECO:0000303|PubMed:27448097};
DE AltName: Full=Component of oligomeric Golgi complex 4 {ECO:0000303|PubMed:27448097};
GN Name=COG4 {ECO:0000303|PubMed:27448097};
GN OrderedLocusNames=At4g01395 {ECO:0000312|Araport:AT4G01395};
GN ORFNames=F3D13.1 {ECO:0000312|EMBL:AAC19289.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP INTERACTION WITH COG2 AND COG3, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=27448097; DOI=10.1371/journal.pgen.1006140;
RA Tan X., Cao K., Liu F., Li Y., Li P., Gao C., Ding Y., Lan Z., Shi Z.,
RA Rui Q., Feng Y., Liu Y., Zhao Y., Wu C., Zhang Q., Li Y., Jiang L., Bao Y.;
RT "Arabidopsis COG complex subunits COG3 and COG8 modulate golgi morphology,
RT vesicle trafficking homeostasis and are essential for pollen tube growth.";
RL PLoS Genet. 12:E1006140-E1006140(2016).
CC -!- FUNCTION: Required for normal Golgi function.
CC {ECO:0000250|UniProtKB:Q9H9E3}.
CC -!- SUBUNIT: Component of the conserved oligomeric Golgi complex which is
CC composed of eight different subunits and is required for normal Golgi
CC morphology and localization (Probable). Interacts with COG2 and COG3
CC (PubMed:27448097). {ECO:0000269|PubMed:27448097,
CC ECO:0000305|PubMed:27448097}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:Q9H9E3}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:Q9H9E3}; Cytoplasmic side
CC {ECO:0000250|UniProtKB:Q9H9E3}.
CC -!- SIMILARITY: Belongs to the COG4 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC19289.1; Type=Erroneous gene model prediction; Note=The predicted gene has been split into 2 genes: At4g01395 and At4g01400.; Evidence={ECO:0000305};
CC Sequence=CAB80949.1; Type=Erroneous gene model prediction; Note=The predicted gene has been split into 2 genes: At4g01395 and At4g01400.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF069300; AAC19289.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161491; CAB80949.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; ANM66918.1; -; Genomic_DNA.
DR EMBL; AY120763; AAM53321.1; -; mRNA.
DR EMBL; BT010336; AAQ56779.1; -; mRNA.
DR PIR; C85018; C85018.
DR PIR; T01377; T01377.
DR RefSeq; NP_001154198.1; NM_001160726.2.
DR AlphaFoldDB; Q8L838; -.
DR SMR; Q8L838; -.
DR BioGRID; 13234; 8.
DR IntAct; Q8L838; 1.
DR STRING; 3702.AT4G01400.1; -.
DR PaxDb; Q8L838; -.
DR PRIDE; Q8L838; -.
DR ProteomicsDB; 240914; -.
DR EnsemblPlants; AT4G01395.1; AT4G01395.1; AT4G01395.
DR GeneID; 827943; -.
DR Gramene; AT4G01395.1; AT4G01395.1; AT4G01395.
DR KEGG; ath:AT4G01395; -.
DR Araport; AT4G01395; -.
DR eggNOG; KOG0412; Eukaryota.
DR eggNOG; KOG4197; Eukaryota.
DR HOGENOM; CLU_014853_2_0_1; -.
DR InParanoid; Q8L838; -.
DR OMA; SECQQRV; -.
DR OrthoDB; 376278at2759; -.
DR PRO; PR:Q8L838; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q8L838; baseline and differential.
DR Genevisible; Q8L838; AT.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR013167; COG_su4.
DR Pfam; PF08318; COG4; 1.
DR SMART; SM00762; Cog4; 1.
PE 1: Evidence at protein level;
KW Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW Transport.
FT CHAIN 1..738
FT /note="Conserved oligomeric Golgi complex subunit 4"
FT /id="PRO_0000363409"
SQ SEQUENCE 738 AA; 82978 MW; EF9B1B0FDA7B15CE CRC64;
MPEIEQDDAA AETVDSSTVK FGTPEALEYV RSLTDVGAMT RLLHECIAYQ RSLDSDLDTL
LSQRTELDRN LVQLQRSAEI LDIVKADADH MLGNVRSTCD LADQVSGKVR ELDLAQSRVN
VTLSRIDAIV ERGNCIEGVK TALESEDYES AAKFVQRFLQ IDLQYKDSGS DQSEQLHASK
EQLEGIAKKK LLAAIDQRDH PTILRFVRLY SPLGMETEGL QLYVGYLKKV IALRGRMEYE
NVVELMEQGL GQVNFVGCLT NLFKDIVMAI EENDEILRGL CGEDGVAYAI CELQEECDLR
GSLILKKYMD FRKLAILASD INNSPNLNIL PGGASEGPDP REVELYVEEI LSLMQLGEDY
TEFMVSKIKS LTSVDPELLP TATKAFRNKS FSKAIQDVTR YYVILEGFFM VENVRKAIRI
DEHVPDSLTT SMVDDVFYVL QSCLRRAIST SNISSVIAVL SYAGSLLGND YHEALQQKIR
EPNLGARLFL GGIGVENTGT EIATALNNMD VSCEYILKLK HEIEEQCTEV FPAPADRERI
KSCLSELGEL SSTFKQLLNS GMEQLVATVT PRIRPVLDTV ATISYELTET EYAENEVNDP
WVQRLLHSVE TNAAWLQPLM TSNNYDSFLH LIIDFIVKRL EVIMMQKRFS QLGGLQLDRD
TRALVSHFSG MTQRTVRDKF ARLTQMATIL NLEKVSEILD FWGENSGPMT WRLTPAEVRR
VLGLRVEFKP ESIAALKL
