COG4_CAEEL
ID COG4_CAEEL Reviewed; 801 AA.
AC Q95XZ0; Q3V5K1; Q95XY9;
DT 15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Conserved oligomeric Golgi complex subunit 4;
DE Short=COG complex subunit 4;
DE AltName: Full=Component of oligomeric Golgi complex 4;
GN Name=cogc-4; ORFNames=Y51H7C.6;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Required for normal Golgi function.
CC {ECO:0000250|UniProtKB:Q9H9E3}.
CC -!- SUBUNIT: Component of the conserved oligomeric Golgi complex which is
CC composed of eight different subunits and is required for normal Golgi
CC morphology and localization. {ECO:0000250|UniProtKB:Q9H9E3}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:Q9H9E3}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:Q9H9E3}; Cytoplasmic side
CC {ECO:0000250|UniProtKB:Q9H9E3}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=a;
CC IsoId=Q95XZ0-1; Sequence=Displayed;
CC Name=b;
CC IsoId=Q95XZ0-2; Sequence=VSP_001129, VSP_001130;
CC Name=c;
CC IsoId=Q95XZ0-3; Sequence=VSP_019284;
CC -!- SIMILARITY: Belongs to the COG4 family. {ECO:0000305}.
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DR EMBL; FO081466; CCD71790.1; -; Genomic_DNA.
DR EMBL; FO081466; CCD71791.1; -; Genomic_DNA.
DR EMBL; FO081466; CCD71792.1; -; Genomic_DNA.
DR RefSeq; NP_001033341.1; NM_001038252.2. [Q95XZ0-3]
DR RefSeq; NP_493966.1; NM_061565.4. [Q95XZ0-1]
DR RefSeq; NP_493967.1; NM_061566.4. [Q95XZ0-2]
DR AlphaFoldDB; Q95XZ0; -.
DR SMR; Q95XZ0; -.
DR BioGRID; 38893; 6.
DR IntAct; Q95XZ0; 4.
DR STRING; 6239.Y51H7C.6a.1; -.
DR iPTMnet; Q95XZ0; -.
DR EPD; Q95XZ0; -.
DR PaxDb; Q95XZ0; -.
DR PeptideAtlas; Q95XZ0; -.
DR PRIDE; Q95XZ0; -.
DR EnsemblMetazoa; Y51H7C.6a.1; Y51H7C.6a.1; WBGene00021784. [Q95XZ0-1]
DR EnsemblMetazoa; Y51H7C.6b.1; Y51H7C.6b.1; WBGene00021784. [Q95XZ0-2]
DR EnsemblMetazoa; Y51H7C.6c.1; Y51H7C.6c.1; WBGene00021784. [Q95XZ0-3]
DR GeneID; 173518; -.
DR KEGG; cel:CELE_Y51H7C.6; -.
DR UCSC; Y51H7C.6a.2; c. elegans. [Q95XZ0-1]
DR CTD; 173518; -.
DR WormBase; Y51H7C.6a; CE26151; WBGene00021784; cogc-4. [Q95XZ0-1]
DR WormBase; Y51H7C.6b; CE26152; WBGene00021784; cogc-4. [Q95XZ0-2]
DR WormBase; Y51H7C.6c; CE39055; WBGene00021784; cogc-4. [Q95XZ0-3]
DR eggNOG; KOG0412; Eukaryota.
DR GeneTree; ENSGT00940000154065; -.
DR HOGENOM; CLU_014853_2_0_1; -.
DR InParanoid; Q95XZ0; -.
DR OMA; SECQQRV; -.
DR OrthoDB; 376278at2759; -.
DR PhylomeDB; Q95XZ0; -.
DR Reactome; R-CEL-6807878; COPI-mediated anterograde transport.
DR Reactome; R-CEL-6811438; Intra-Golgi traffic.
DR PRO; PR:Q95XZ0; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00021784; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017119; C:Golgi transport complex; IBA:GO_Central.
DR GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR GO; GO:0048213; P:Golgi vesicle prefusion complex stabilization; IBA:GO_Central.
DR GO; GO:0035262; P:gonad morphogenesis; IMP:WormBase.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0030334; P:regulation of cell migration; IMP:WormBase.
DR GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; IBA:GO_Central.
DR InterPro; IPR013167; COG_su4.
DR Pfam; PF08318; COG4; 1.
DR SMART; SM00762; Cog4; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Golgi apparatus; Membrane; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..801
FT /note="Conserved oligomeric Golgi complex subunit 4"
FT /id="PRO_0000213506"
FT REGION 397..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..427
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 264..746
FT /note="Missing (in isoform c)"
FT /evidence="ECO:0000305"
FT /id="VSP_019284"
FT VAR_SEQ 477..494
FT /note="SSIVDDVVFIIRKSIRRA -> RCGDKKYRKRPLKQEKIC (in isoform
FT b)"
FT /evidence="ECO:0000305"
FT /id="VSP_001129"
FT VAR_SEQ 495..801
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_001130"
SQ SEQUENCE 801 AA; 91020 MW; 1D22BD2129BBDBB5 CRC64;
MPEPILHSKF LSGLPAGRKN GVRHGEKPEK VGEKQFDFTR KIRELRLELE IKKREEERIE
KDIAIILEEN TIDGGEQNRS FGLAVTRLNN HMLVVENSAK QLTSALKNIS VLADTISGRV
SALDVAKTRV VGCLQLAGDM RDLGVCAEGI DDAIRSEDFE TASQHIHRFL TLDQAVFQIR
EFKQKDATDS IRHSYEVLSS AKERLSKILK SRLTESVQKG DVAEMQRFIK MFPLIHEPDE
GLQRYSVFLN QKIDKLAEDN LAIMKAGGTD DNRRNVLYAD TLFMFFEGVA EIIESNLPVL
EHSYGLEKLL DFMFILQARI DEFFRRLHEE FDTRRRLSHF NRLVDDVIHQ KKAAEAVEDA
PDPMEIDAIA SEICMMNTSA EMYWRFVSRR IGKNEVIRSP SGDGDDEENE EARQERHRLR
KEAKEQKMDQ LLNRSRVGTK MQELIGNYCL LEHFYMLKSV QKAIKSDVKE DAGGLTSSIV
DDVVFIIRKS IRRAAGSGNV DSVCATINNA TALIDTVVHG HLRQSIQQGY VTSSNFASEA
FTAYQQGKPV KEAADAQKEQ FLLALNNSAK LSELLIELQK GLITEWAGVK RPDVEKNKLE
HSTTQIEESA KKLASLAKHG VEELFKSAFK NKIKQGADPY QEIDRQMTMQ DVEYYEAHDP
FMEQFLAQID RLLVENEPLL FADNYQTLLL LTSSEIARQI EQSLAKCQFN RYGALQLDRE
YRQICAYLTN VAGWSAREKV GRLGQIVSLL NVETIDEAME VWHNSKAMTS SATIRTLTLP
EVRKVLALRA DFPTVAIKSI E
