COG4_DROME
ID COG4_DROME Reviewed; 776 AA.
AC Q95TN4; Q9VKU6;
DT 15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Conserved oligomeric Golgi complex subunit 4;
DE Short=COG complex subunit 4;
DE AltName: Full=Component of oligomeric Golgi complex 4 {ECO:0000312|FlyBase:FBgn0032258};
GN Name=Cog4 {ECO:0000312|FlyBase:FBgn0032258};
GN ORFNames=CG7456 {ECO:0000312|FlyBase:FBgn0032258};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-342 AND SER-345, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- FUNCTION: Required for normal Golgi function.
CC {ECO:0000250|UniProtKB:Q9H9E3}.
CC -!- SUBUNIT: Component of the conserved oligomeric Golgi complex which is
CC composed of eight different subunits and is required for normal Golgi
CC morphology and localization. {ECO:0000250|UniProtKB:Q9H9E3}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:Q9H9E3}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:Q9H9E3}; Cytoplasmic side
CC {ECO:0000250|UniProtKB:Q9H9E3}.
CC -!- SIMILARITY: Belongs to the COG4 family. {ECO:0000305}.
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DR EMBL; AE014134; AAF52963.2; -; Genomic_DNA.
DR EMBL; AY058656; AAL13885.1; -; mRNA.
DR RefSeq; NP_609413.1; NM_135569.4.
DR AlphaFoldDB; Q95TN4; -.
DR SMR; Q95TN4; -.
DR BioGRID; 60522; 6.
DR DIP; DIP-22102N; -.
DR IntAct; Q95TN4; 3.
DR STRING; 7227.FBpp0079628; -.
DR iPTMnet; Q95TN4; -.
DR PaxDb; Q95TN4; -.
DR PRIDE; Q95TN4; -.
DR DNASU; 34442; -.
DR EnsemblMetazoa; FBtr0080038; FBpp0079628; FBgn0032258.
DR GeneID; 34442; -.
DR KEGG; dme:Dmel_CG7456; -.
DR UCSC; CG7456-RA; d. melanogaster.
DR CTD; 25839; -.
DR FlyBase; FBgn0032258; Cog4.
DR VEuPathDB; VectorBase:FBgn0032258; -.
DR eggNOG; KOG0412; Eukaryota.
DR GeneTree; ENSGT00940000154065; -.
DR HOGENOM; CLU_014853_2_0_1; -.
DR InParanoid; Q95TN4; -.
DR OMA; SECQQRV; -.
DR OrthoDB; 376278at2759; -.
DR PhylomeDB; Q95TN4; -.
DR Reactome; R-DME-6807878; COPI-mediated anterograde transport.
DR Reactome; R-DME-6811438; Intra-Golgi traffic.
DR BioGRID-ORCS; 34442; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 34442; -.
DR PRO; PR:Q95TN4; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0032258; Expressed in embryonic/larval hemocyte (Drosophila) and 38 other tissues.
DR Genevisible; Q95TN4; DM.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017119; C:Golgi transport complex; IDA:FlyBase.
DR GO; GO:0007030; P:Golgi organization; ISS:FlyBase.
DR GO; GO:0048213; P:Golgi vesicle prefusion complex stabilization; IBA:GO_Central.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; ISS:FlyBase.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; IBA:GO_Central.
DR InterPro; IPR013167; COG_su4.
DR Pfam; PF08318; COG4; 1.
DR SMART; SM00762; Cog4; 1.
PE 1: Evidence at protein level;
KW Golgi apparatus; Membrane; Phosphoprotein; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..776
FT /note="Conserved oligomeric Golgi complex subunit 4"
FT /id="PRO_0000213507"
FT MOD_RES 342
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 345
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
SQ SEQUENCE 776 AA; 87715 MW; BA009CD98177820A CRC64;
MSVLEQLGAL DIGTNEQVDE TLQRIADEEA KVNEKLESLL AKQCQIEAKM SGIGRSLSLL
HTVDSDSNKL NDQIVNTAQL AESVSAKVRR LDLARCRASE CQQRVHDLID LHLCSQGVVK
AIGEEDYEKS ATHIARFLAM DQQLLRRTAD DVQGSITSVS DAVKTLEDAT EKTRVLIAKR
FDEAVKADDL ASVERFFKIF PLVGCHRTGI EKFSLYICQK LANKAQKELR NAQDIAKAES
RLQLAYADRL TAILENFARV VEVNQPIIEA FYGQASSSLI DMVSILQHEC DTEVKNLLME
FNKNRQIQYR SKQVNESTQR SAGGGNLGSN SIQALGHYRK PSGGSVDKLN PKEIDAIIAE
ITVMHARVEL YFRFMRRRLQ VHVETCVPEK EQFDIMERYE KIMKNSDLRR QMQEILSTYL
LLERYFMEES VLKAIGLDTY ESGQQCSSMV DDVFFILRKS IRRALTTQSI NGTCAVINNV
AACLDGDFVN ALKAPLKSGY PSGYIDLAQA YNAIQTSLQQ GKLHSSDADR GRANFLVQLN
NADISTEYIE TLCQTMEQEI AGTFPQTTQV ERQMLDSCLT ELKAVRDALK ATVDFGMQQL
RSSVIKPRLN PWINQFLNYS HNLNEEELAA YEAGETFVQF FIVQLDGLLN SFKNSLSPRN
YDALVSILAT EVTIQLERAI KKISFNRLGG LVLDQEVRAL GSYLTGATSW SVRDKMTRIS
QIATLLNLDK ITELSEYWNP ENNKEMSSWH LTPNEVRTFL TLRNDFRIED IKRLQL
