COG4_MOUSE
ID COG4_MOUSE Reviewed; 785 AA.
AC Q8R1U1; Q3T9K1;
DT 30-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Conserved oligomeric Golgi complex subunit 4;
DE Short=COG complex subunit 4;
DE AltName: Full=Component of oligomeric Golgi complex 4;
GN Name=Cog4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=NOD;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, Liver, Lung, Pancreas, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Required for normal Golgi function. Plays a role in SNARE-pin
CC assembly and Golgi-to-ER retrograde transport via its interaction with
CC SCFD1. {ECO:0000250|UniProtKB:Q9H9E3}.
CC -!- SUBUNIT: Monomer. Component of the conserved oligomeric Golgi (COG)
CC complex which is composed of eight different subunits and is required
CC for normal Golgi morphology and localization. Mediates interaction of
CC SCFD1 with the COG complex. Interacts with STX5.
CC {ECO:0000250|UniProtKB:Q9H9E3}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000250|UniProtKB:Q9H9E3}. Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:Q9H9E3}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:Q9H9E3}; Cytoplasmic side
CC {ECO:0000250|UniProtKB:Q9H9E3}.
CC -!- SIMILARITY: Belongs to the COG4 family. {ECO:0000305}.
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DR EMBL; AK172465; BAE43019.1; -; mRNA.
DR EMBL; CH466525; EDL11474.1; -; Genomic_DNA.
DR EMBL; BC023120; AAH23120.1; -; mRNA.
DR CCDS; CCDS40477.1; -.
DR RefSeq; NP_598734.1; NM_133973.2.
DR AlphaFoldDB; Q8R1U1; -.
DR SMR; Q8R1U1; -.
DR IntAct; Q8R1U1; 1.
DR STRING; 10090.ENSMUSP00000034203; -.
DR iPTMnet; Q8R1U1; -.
DR PhosphoSitePlus; Q8R1U1; -.
DR EPD; Q8R1U1; -.
DR jPOST; Q8R1U1; -.
DR MaxQB; Q8R1U1; -.
DR PaxDb; Q8R1U1; -.
DR PeptideAtlas; Q8R1U1; -.
DR PRIDE; Q8R1U1; -.
DR ProteomicsDB; 283487; -.
DR Antibodypedia; 29988; 115 antibodies from 20 providers.
DR DNASU; 102339; -.
DR Ensembl; ENSMUST00000034203; ENSMUSP00000034203; ENSMUSG00000031753.
DR GeneID; 102339; -.
DR KEGG; mmu:102339; -.
DR UCSC; uc009nle.1; mouse.
DR CTD; 25839; -.
DR MGI; MGI:2142808; Cog4.
DR VEuPathDB; HostDB:ENSMUSG00000031753; -.
DR eggNOG; KOG0412; Eukaryota.
DR GeneTree; ENSGT00940000154065; -.
DR InParanoid; Q8R1U1; -.
DR OMA; SECQQRV; -.
DR OrthoDB; 376278at2759; -.
DR PhylomeDB; Q8R1U1; -.
DR TreeFam; TF105835; -.
DR Reactome; R-MMU-6807878; COPI-mediated anterograde transport.
DR Reactome; R-MMU-6811438; Intra-Golgi traffic.
DR Reactome; R-MMU-6811440; Retrograde transport at the Trans-Golgi-Network.
DR BioGRID-ORCS; 102339; 16 hits in 74 CRISPR screens.
DR ChiTaRS; Cog4; mouse.
DR PRO; PR:Q8R1U1; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q8R1U1; protein.
DR Bgee; ENSMUSG00000031753; Expressed in dorsal pancreas and 252 other tissues.
DR ExpressionAtlas; Q8R1U1; baseline and differential.
DR Genevisible; Q8R1U1; MM.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017119; C:Golgi transport complex; ISO:MGI.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0070085; P:glycosylation; ISO:MGI.
DR GO; GO:0007030; P:Golgi organization; ISO:MGI.
DR GO; GO:0048213; P:Golgi vesicle prefusion complex stabilization; ISO:MGI.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0000301; P:retrograde transport, vesicle recycling within Golgi; ISO:MGI.
DR GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; ISO:MGI.
DR InterPro; IPR013167; COG_su4.
DR Pfam; PF08318; COG4; 1.
DR SMART; SM00762; Cog4; 1.
PE 1: Evidence at protein level;
KW Acetylation; Cytoplasm; Golgi apparatus; Membrane; Phosphoprotein;
KW Protein transport; Reference proteome; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q9H9E3"
FT CHAIN 2..785
FT /note="Conserved oligomeric Golgi complex subunit 4"
FT /id="PRO_0000213505"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2..84
FT /note="Interaction with SCFD1"
FT /evidence="ECO:0000250|UniProtKB:Q9H9E3"
FT REGION 85..153
FT /note="Interaction with STX5"
FT /evidence="ECO:0000250|UniProtKB:Q9H9E3"
FT REGION 618..740
FT /note="D domain"
FT /evidence="ECO:0000250|UniProtKB:Q9H9E3"
FT REGION 741..785
FT /note="E domain; essential for proper cell surface
FT glycosylation"
FT /evidence="ECO:0000250|UniProtKB:Q9H9E3"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q9H9E3"
FT MOD_RES 6
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H9E3"
SQ SEQUENCE 785 AA; 88661 MW; 057D846C5319E4EE CRC64;
MAEVESPLKL SGAPPPPEGV GGGHCSEIST ELIRSLTELQ ELEAVYERLC GEEKAVEKEL
DALLEQQNTI ESKMVTLHRM GPSLQLIEGD AKQLAGMITF TCSLAENVSS KVRQLDLAKN
RLYQAIQRAD DILDLKFCMD GVQTALRNED YEQAAAHIHR YLCLDKSVIE LSRQGKEGSM
IDANLKLLQE AEQRLKAIVA EKFAIATKEG DLPQVERFFK IFPLLGLHED GLSKFSEYLC
KQVASKAEEN LLLVLGSDMS DRRAAVIFAD TLTLLFEGIA RIVETHQPIV ETYYGPGRLF
TLIKYLQVEC DTQVEKVVNK FIKQRDYHQQ FRLVQSNLMR NSATEKIEPR ELDPVLTEVT
LMNARSELYL RFLRKRISAD FEVGDSMASE EVKQEHQKCL DKLLNNCLLS CTMQELIGFY
ITMEEYFMRE TVNKAVALDT YEKGQLTSSM VDDVFYIVKK CIGRALSSSN IDCLCAMINL
ATRELEADFR DVLCNKLRMG FPATTLQDIQ RGVTSAVNIM HSSLQQGKFD TKGIESTDEA
KLSFLVTLNN VEVCSENIST LKKTLESDCT KLFSQGIGGE QAQAKFDSCL SDLAAVSNKF
RDLLQEGLAE LNSSAVKPQV QPWINTFLSV SHSIEEEEFN DYEANDPWVQ QFILNLEQQM
AEFKASLSPV IYDSLTGLMT SLVAVELEKV VLKSTFNRLG GLQFDKELRS LIAYLTTVTT
WTIRDKFARL SQMATILNLE RVTEILDYWG ANSGPLTWRL TPAEVRQVLA LRIDFRNEDI
KRLRL
